Faculty profile

Thomas Klonisch

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ProfessorDepartment of Human Anatomy and Cell ScienceUniversity of Manitoba

Thomas Klonisch

Professor

Department of Human Anatomy and Cell Science

Max Rady College of Medicine

University of Manitoba

Winnipeg, Manitoba, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
19 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 10 research grants (5 NSERC, 4 CIHR, 1 SSHRC), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Manitoba profile.

Molecular determinants of brain tumor progression Molecular mechanisms of therapy resistance Novel ABL kinase inhibitors for brain tumor treatment Modulating innate immune responses to treat brain tumors

Latest papers

Neuroglial-Breast Cancer Crosstalk Shapes the Brain Metastatic Niche.
Cells · 2026 · senior author
A customized affordable multiplexed immunofluorescence method visualizes early changes in the mouse brain microenvironment upon laser cytoreduction.
Frontiers in cellular neuroscience · 2025 · senior author
The Brain-Penetrant Pan-ErbB Inhibitor Poziotinib Effectively Targets HER2+ Breast Cancer Brain Metastases.
Cancer research · 2025

All 96 publications

Latest funding

9th International Conference on Relaxin, Related Peptides, and Receptors
CIHR · 2023 · Nominated PI
$10,000
Novel functions of C1q/TNF-related relaxin receptor ligands
NSERC · 2023 · Principal investigator
$90,000
Molecular determinants of Zika virus propagation and pathogenesis in human glial cells
CIHR · 2021 · Co-investigator
$100,000

All 13 grants and awards

96 publications.

Neuroglial-Breast Cancer Crosstalk Shapes the Brain Metastatic Niche.

Hombach-Klonisch S, Hall E, Amin R, Fedora E, Vriend J, Pitz M, Klonisch T

Cells2026Senior author

DOI: 10.3390/cells15080735 PMID: 42041600

A customized affordable multiplexed immunofluorescence method visualizes early changes in the mouse brain microenvironment upon laser cytoreduction.

Shanmugam Anandhan S, Spence J, Begum F, Kaur N, Henderson D, Hombach-Klonisch S, Klonisch T

Frontiers in cellular neuroscience2025Senior author

DOI: 10.3389/fncel.2025.1553058 PMID: 40989806

The Brain-Penetrant Pan-ErbB Inhibitor Poziotinib Effectively Targets HER2+ Breast Cancer Brain Metastases.

Ippolitov D, Lin YH, Spence J, Glogowska A, Thanasupawat T, Beiko J, Del Bigio MR, Xu X, Wang AQ, Williams D, Calvo R, Kapoor A, Marugan JJ, Henderson MJ, Klonisch T, Hombach-Klonisch S

Cancer research2025

DOI: 10.1158/0008-5472.can-24-1793 PMID: 39932819

Distinct spatial N-glycan profiles reveal glioblastoma-specific signatures.

Angerstein AO, Young LEA, Thanasupawat T, Vriend J, Grimsley G, Lun X, Senger DL, Sinha N, Beiko J, Pitz M, Hombach-Klonisch S, Drake RR, Klonisch T

The Journal of pathology2025Senior author

DOI: 10.1002/path.6401 PMID: 39967571

An introduction to the special issue "9th International Conference on Relaxin and Related Peptides".

Bennett RG, Hombach-Klonisch S, Klonisch T, Wilson BC

Biochemical pharmacology2025

DOI: 10.1016/j.bcp.2025.116775 PMID: 39862991

Proteomic and cytokine profiling of a CTRP8-RXFP1 glioma mouse model.

Thanasupawat T, Mejia YP, Anandhan SS, Guo Y, Tiwana J, Fernando A, Glogowska A, Shafai T, daSilva S, Kaur N, Begum F, Zahedi R, Hombach-Klonisch S, Klonisch T

Biochemical pharmacology2025Senior author

DOI: 10.1016/j.bcp.2024.116722 PMID: 39709036

Emerging roles of High Mobility Group A (HMGA) family members in nuclear organization.

Singh M, Thanasupawat T, Klonisch T, Hombach-Klonisch S

Biochemistry and cell biology = Biochimie et biologie cellulaire2025

DOI: 10.1139/bcb-2025-0100 PMID: 41160894

C1QTNF Related protein 8 (CTRP8) is a marker of myeloid derived innate immune cell populations in the human breast cancer microenvironment.

Arreza L, Thanasupawat T, Krishnan SN, Kraljevic M, Klonisch T, Hombach-Klonisch S

Biochemical pharmacology2024

DOI: 10.1016/j.bcp.2024.116624 PMID: 39542181

Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment.

Bonni S, Brindley DN, Chamberlain MD, Daneshvar-Baghbadorani N, Freywald A, Hemmings DG, Hombach-Klonisch S, Klonisch T, Raouf A, Shemanko CS, Topolnitska D, Visser K, Vizeacoumar FJ, Wang E, Gibson SB

Cancers2024

DOI: 10.3390/cancers16050911 PMID: 38473273

Overcoming brain-derived therapeutic resistance in HER2+ breast cancer brain metastasis.

Ippolitov D, Lin YH, Spence J, Glogowska A, Thanasupawat T, Beiko J, Del Bigio MR, Xu X, Wang A, Calvo R, Kapoor A, Marugan JJ, Henderson MJ, Klonisch T, Hombach-Klonisch S

bioRxiv : the preprint server for biology2024

DOI: 10.1101/2024.02.19.581073 PMID: 38529509

9th International Conference on Relaxin, Related Peptides, and Receptors

Nominated PICIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Klonisch, Thomas

Keywords: Cancer; Cryo-Em Structure/Function; Fibrosis; G Protein Coupled Receptors; Immunomodulation; Receptor Analogues; Relaxin-Like Hormones; Rxfp Small Molecules

$10,000

Novel functions of C1q/TNF-related relaxin receptor ligands

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Klonisch, Thomas

Keywords: c1q/tnf-related proteins; ctrp; relaxin receptor; rxfp1; mast cells; macrophages; pref-1; notch1; glial cells; autophagy

$90,000

Molecular determinants of Zika virus propagation and pathogenesis in human glial cells

Co-investigatorCIHR2021Project Grant - Priority Announcement: Infection and Immunity

Principal investigators: Coombs, Kevin M

Keywords: Cell Culture; Functional Characterization; Genetic Knockdown; Viral Infection

$100,000

Laser Thermal Immunomodulation in the Brain

Principal investigatorNSERC2021Alliance Grants

Principal investigators: Klonisch, Thomas TJ

Keywords: brain cellular microenvironment; cABL kinases; cellular immunity; Immunomodulation; Laser thermal application; microglia; mouse models; neurovascular unit; RXFP1 agonists; spatial tissue profiling

$150,000

Optogenetic electronics meets chemoresistant glioblastoma.

Principal investigatorSSHRC2021New Frontiers in Research Fund - Exploration

Principal investigators: Klonisch, Thomas

Keywords: in vivo recording implantable wireless device brain tumor tumor microenvironment optogenetics

$250,000

Integrated multi-omic delineation of SARS-CoV-2-dysregulated cellular processes

Co-investigatorCIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Therapeutics

Principal investigators: Coombs, Kevin M

Keywords: Bioinformatics; Gene Silencing; Host Response; Proteomics

$790,162

Development and clinical assessment of novel biomarker drugs targeting SSAT1 for detection and therapeutic monitoring of glioblastoma

Co-investigatorNSERC2019Collaborative Health Research Projects

Principal investigators: Miller, Donald

$342,671

Development and clinical assessment of novel biomarker drugs targeting SSAT1 for detection and therapeutic monitoring of glioblastoma

Principal investigatorCIHR2018Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Miller, Donald W; Maula Bux, Rashid A; Klonisch, Thomas; Lakowski, Ted M

Keywords: Biomarker; Blood-Brain Barrier; Drug Acetylation; Early Detection; Glioblastoma; Metabolomics; Spermine Spermidine Acetyl Transferase 1; Therapeutic Monitoring

$405,529

Highly selective targeting of ABL kinase in patient-derived brain tumor initiating cells.

Nominated PICIHR2018CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Klonisch, Thomas

Keywords: Abl Kinase

$60,000

Novel roles of C1q tumor necrosis factor-related proteins (CTRPs) in relaxin receptor biology

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Klonisch, Thomas

$204,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 27, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Thomas Klonisch

Research

Latest papers

Latest funding

Neuroglial-Breast Cancer Crosstalk Shapes the Brain Metastatic Niche.

A customized affordable multiplexed immunofluorescence method visualizes early changes in the mouse brain microenvironment upon laser cytoreduction.

The Brain-Penetrant Pan-ErbB Inhibitor Poziotinib Effectively Targets HER2+ Breast Cancer Brain Metastases.

Distinct spatial N-glycan profiles reveal glioblastoma-specific signatures.

An introduction to the special issue "9th International Conference on Relaxin and Related Peptides".

Proteomic and cytokine profiling of a CTRP8-RXFP1 glioma mouse model.

Emerging roles of High Mobility Group A (HMGA) family members in nuclear organization.

C1QTNF Related protein 8 (CTRP8) is a marker of myeloid derived innate immune cell populations in the human breast cancer microenvironment.

Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment.

Overcoming brain-derived therapeutic resistance in HER2+ breast cancer brain metastasis.

9th International Conference on Relaxin, Related Peptides, and Receptors

Novel functions of C1q/TNF-related relaxin receptor ligands

Molecular determinants of Zika virus propagation and pathogenesis in human glial cells

Laser Thermal Immunomodulation in the Brain

Optogenetic electronics meets chemoresistant glioblastoma.

Integrated multi-omic delineation of SARS-CoV-2-dysregulated cellular processes

Development and clinical assessment of novel biomarker drugs targeting SSAT1 for detection and therapeutic monitoring of glioblastoma

Development and clinical assessment of novel biomarker drugs targeting SSAT1 for detection and therapeutic monitoring of glioblastoma

Highly selective targeting of ABL kinase in patient-derived brain tumor initiating cells.

Novel roles of C1q tumor necrosis factor-related proteins (CTRPs) in relaxin receptor biology

Frequent collaborators

Sabine Hombach-Klonisch

Marshall Pitz

Sabine Mai

Eftekhar Eftekharpour

Yvonne Myal

Mohsen Akbari

Prashen Chelikani

Francis Lin

Song Liu

Elissavet Kardami

Leigh Murphy

Johan van Lierop

Malcolm Xing

Shirin Bonni

Mazdak Khajehpour

Wen Zhong

Christopher Pascoe

Barbara Triggs-Raine

Frank Schweizer

Hassan Marzban

Laura Trinkle-Mulcahy

David Levin

Andrew Halayko

Sam Kung

René Zahedi

Edwin Wang

Jude Uzonna

John Wilkins

Neeloffer Mookherjee

Andrew Freywald

Jean-Eric Ghia

Martin Post