Faculty profile
Jeffrey Wigle
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Research
Latest papers
Preliminary Validation of a Novel Genetic Knowledge Scale for Familial Hypercholesterolemia: Evaluation of Face Validity and Core Concepts.
Journal of genetic counseling · 2026
A Comprehensive Analysis of the Efficacy of Resveratrol in Atherosclerotic Cardiovascular Disease, Myocardial Infarction and Heart Failure.
Molecules (Basel, Switzerland) · 2021
Comparative and Combinatorial Effects of Resveratrol and Sacubitril/Valsartan alongside Valsartan on Cardiac Remodeling and Dysfunction in MI-Induced Rats.
Molecules (Basel, Switzerland) · 2021
Latest funding
- $1,040,400
Novel regulators of dermal wound healing
CIHR · 2022 · Co-investigator
- $192,000
Transcriptional regulation of fibroblast generation in the embryonic mouse heart.
NSERC · 2019 · Principal investigator
- $605,234
Role of Ski in myofibroblast regulation in heart failure.
CIHR · 2011 · Co-investigator
7 publications.
Preliminary Validation of a Novel Genetic Knowledge Scale for Familial Hypercholesterolemia: Evaluation of Face Validity and Core Concepts.
Moss E, Wigle J, Carriles-Landry C, Mitchell K, Wand H, Slamon J, Mostafavi R, Yonda A, Christian S
A Comprehensive Analysis of the Efficacy of Resveratrol in Atherosclerotic Cardiovascular Disease, Myocardial Infarction and Heart Failure.
Raj P, Thandapilly SJ, Wigle J, Zieroth S, Netticadan T
Comparative and Combinatorial Effects of Resveratrol and Sacubitril/Valsartan alongside Valsartan on Cardiac Remodeling and Dysfunction in MI-Induced Rats.
Raj P, Sayfee K, Parikh M, Yu L, Wigle J, Netticadan T, Zieroth S
Characterization of the inhibitory effect of an extract of Prunella vulgaris on Ebola virus glycoprotein (GP)-mediated virus entry and infection.
Zhang X, Ao Z, Bello A, Ran X, Liu S, Wigle J, Kobinger G, Yao X
Conjugated linoleic acid improves blood pressure by increasing adiponectin and endothelial nitric oxide synthase activity.
DeClercq V, Taylor CG, Wigle J, Wright B, Tworek L, Zahradka P
Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway.
Thandapilly SJ, Louis XL, Yang T, Stringer DM, Yu L, Zhang S, Wigle J, Kardami E, Zahradka P, Taylor C, Anderson HD, Netticadan T
Defects in ryanodine receptor function are associated with systolic dysfunction in rats subjected to volume overload.
Juric D, Yao X, Thandapilly S, Louis X, Cantor E, Chaze B, Wojciechowski P, Vasanji Z, Yang T, Wigle J, Netticadan T
Novel regulators of dermal wound healing
Principal investigators: Dixon, Ian Michael C
Keywords: A1-Anti Trypsin; Dermal Wound Healing; Fibroblast; Keratinocytes; Scleraxis; Ski; Skin; Tgfb
Transcriptional regulation of fibroblast generation in the embryonic mouse heart.
Principal investigators: Wigle, Jeffrey
Keywords: cardiac development; Endothelial to mesenchymal transition; enhancer assays; epithelial to mesenchymal transition; Fibroblast; Homeodomain transcription factors; Myofibroblast; Phenotype switching; Transcription factor
Role of Ski in myofibroblast regulation in heart failure.
Principal investigators: Dixon, Ian Michael C
Keywords: Cardiac Fibrosis; Cardiac Myofibroblast; Cardiac Remodeling; Cellular And Animal Models; Heart Failure; Myocardial Infarction; Myocardial Protection
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Carla Taylor and Peter Zahradka: 6 shared papers
- Elissavet Kardami and Peter Zahradka: 3 shared papers
- Peter Zahradka and Jeffrey Wigle: 2 shared papers
- Elissavet Kardami and Carla Taylor: 1 shared paper
- Elissavet Kardami and Jeffrey Wigle: 1 shared paper
- Carla Taylor and Jeffrey Wigle: 1 shared paper
- Biochemistry & Medical Genetics
- Physiology and Pathophysiology
- Human Nutritional Sciences
- Human Anatomy & Cell Science
Co-authors at University of Manitoba, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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