Faculty profile
Keith Poole
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Latest papers
Lysine polyphosphate modifications contribute to virulence factors in Pseudomonas aeruginosa.
mBio · 2025
The aminoglycoside resistance-promoting AmgRS envelope stress-responsive two-component system in Pseudomonas aeruginosa is zinc-activated and protects cells from zinc-promoted membrane damage.
Microbiology (Reading, England) · 2019 · first author
Structure-guided disruption of the pseudopilus tip complex inhibits the Type II secretion in Pseudomonas aeruginosa.
PLoS pathogens · 2018
Latest funding
- $703,790
Contribution of pathoadaptive mutations to antibiotic resistance development in chronic lung infections of Pseudomonas aeruginosa
CIHR · 2015 · Nominated PI
Team in Antibiotic Resistance Genomics (TARGet)
CIHR · 2010 · Principal investigator
- $697,215
Environmental influences on multidrug efflux gene expression and antibiotic resistance in P. aeruginosa
CIHR · 2009 · Nominated PI
41 publications.
Lysine polyphosphate modifications contribute to virulence factors in Pseudomonas aeruginosa.
Lehotsky K, Neville N, Martins I, Poole K, Jia Z
The aminoglycoside resistance-promoting AmgRS envelope stress-responsive two-component system in Pseudomonas aeruginosa is zinc-activated and protects cells from zinc-promoted membrane damage.
Poole K, Hay T, Gilmour C, Fruci M
Structure-guided disruption of the pseudopilus tip complex inhibits the Type II secretion in Pseudomonas aeruginosa.
Zhang Y, Faucher F, Zhang W, Wang S, Neville N, Poole K, Zheng J, Jia Z
Aminoglycoside-inducible expression of the mexAB-oprM multidrug efflux operon in Pseudomonas aeruginosa: Involvement of the envelope stress-responsive AmgRS two-component system.
Fruci M, Poole K
Meropenem potentiation of aminoglycoside activity against Pseudomonas aeruginosa: involvement of the MexXY-OprM multidrug efflux system
Poole K, Gilmour C, Farha MA, Parkins MD, Klinoski R, Brown ED
Rifampicin potentiation of aminoglycoside activity against cystic fibrosis isolates of Pseudomonas aeruginosa.
Mikalauskas A, Parkins MD, Poole K
At the Nexus of Antibiotics and Metals: The Impact of Cu and Zn on Antibiotic Activity and Resistance.
Poole K
Editorial: Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria.
Vargiu AV, Pos KM, Poole K, Nikaido H
Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System
Poole K, Gilmour C, Farha MA, Mullen E, Lau CH-F, Brown ED
Polymyxin Susceptibility in Pseudomonas aeruginosa Linked to the MexXY-OprM Multidrug Efflux System.
Poole K, Lau CH, Gilmour C, Hao Y, Lam JS
Contribution of pathoadaptive mutations to antibiotic resistance development in chronic lung infections of Pseudomonas aeruginosa
Principal investigators: Poole, Keith R
Keywords: Antibiotic Resistance; Chronic Infection; Mutation; Pseudomonas Aeruginosa; Stress Response
Team in Antibiotic Resistance Genomics (TARGet)
Principal investigators: Wright, Gerard D; Boerlin, Patrick; Higgs, Paul G; Melano, Roberto G; Mulvey, Michael R; Poole, Keith R; Roy, Paul H
Keywords: Antibiotic; Beta-Lactamase; Database; Diagnostics; Drug Discovery; Genomics; High Throughput Screening; Next Generation Sequencing; Transcriptomics
Environmental influences on multidrug efflux gene expression and antibiotic resistance in P. aeruginosa
Principal investigators: Poole, Keith R
Keywords: Antibiotic Resistance; Efflux; Pseudomonas Aeruginosa; Regulation
Use of a fluorescence spectrophotometer in the development of a fluorescence-based assay of bacterial multidrug efflux system
Principal investigators: Poole, Keith
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Biomedical and Molecular Sciences
- Biochemistry & Biomedical Sciences
- Biochemistry, Microbiology and Immunology
- Other
Co-authors at Queen's University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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