Zongchao Jia, Queen's University

Research

Crc

Latest papers

Polyphosphate as a novel regulator of super-enhancer complexes: disruption of phase separation and gene expression.
Nucleic acids research · 2026 · senior author
N-Myristoyltransferase 2 Is Regulated by Polyphosphate-Driven Lysine Interactions.
Biomolecules · 2026 · senior author
Mechanistic Insights into the Inhibition of Streptococcus mutans Biofilms by Chlorogenic Acid.
ACS chemical biology · 2026

All 164 publications

Latest funding

Protein Modification: From Monophosphate to Polyphosphate
NSERC · 2024 · Principal investigator
$47,000
Developing a new class of P. aeruginosa antivirulence drug using a novel microsensor and electrokinetics technology
SSHRC · 2021 · Principal investigator
$250,000
STRUCTURAL AND FUNCTIONAL INSIGHTS INTO ALPHA-KINASES AND THEIR REGULATION
NSERC · 2018 · Principal investigator
$414,000

All 23 grants and awards

From the 150 most recent of 164 publications.

01

Polyphosphate as a novel regulator of super-enhancer complexes: disruption of phase separation and gene expression.

Yang Z, Jia Z

Nucleic acids research2026Senior author

DOI: 10.1093/nar/gkag530 PMID: 42186815

02

N-Myristoyltransferase 2 Is Regulated by Polyphosphate-Driven Lysine Interactions.

Martins I, Bailey K, Ge A, Belrose E, Yang X, Jia Z

Biomolecules2026Senior author

DOI: 10.3390/biom16081096 PMID: 42650764

03

Mechanistic Insights into the Inhibition of Streptococcus mutans Biofilms by Chlorogenic Acid.

Wang L, Li X, Liu P, Wu Y, Zheng J, Jia Z, Pei H, Cao X

ACS chemical biology2026

DOI: 10.1021/acschembio.5c01039 PMID: 42044477

04

Inorganic Polyphosphate in Mammals: Mechanisms, Maladies, and Moving Forward.

Mendelsohn Aviv H, Yang Z, Jia Z

Biomolecules2026Senior author

DOI: 10.3390/biom16010127 PMID: 41594667

05

Discovery of polyphosphate-interacting human lysine-rich proteins and their functional implications.

Yang Z, Jin J, Lehotsky K, Martins I, Belrose E, Neville N, Jia Z

International journal of biological macromolecules2026Senior author

DOI: 10.1016/j.ijbiomac.2025.149335 PMID: 41319782

06

Alexidine is a TAZ-specific small-molecule inhibitor that suppresses breast cancer invasion and metastasis.

Ge A, Niu L, Rubino R, Seaman K, Song X, Hao Y, Klupt K, Iaboni N, Jia Z, You L, Nicol CJB, Fu H, Du Y, Yang X

iScience2025

DOI: 10.1016/j.isci.2025.114116 PMID: 41438036

07

A Legionella pneumophila T4SS effector protein (Ravl) triggers mitochondrial fragmentation through phosphoinositide phosphatase activity.

Zhang R, Zhang M, Li X, Lu Z, Song C, Du Y, Chesterman C, van Staalduinen L, Wang Y, Pei H, Jia Z, Zheng J

International journal of biological macromolecules2025

DOI: 10.1016/j.ijbiomac.2025.148613 PMID: 41167367

08

Comb-Tipped Coupled Cantilever Sensor for Enhanced Real-Time Detection of E. coli Bacteria.

Bukhari SAR, Alaei E, Jia Z, Lai Y

Sensors (Basel, Switzerland)2025

DOI: 10.3390/s25134145 PMID: 40648400

09

Discovery of Dietary Plant Flavonols as Novel Potent Inhibitors Targeting DYRK1A Kinase.

Jin J, Zhou Q, Guo B, Jia Z

Biomolecules2025Senior author

DOI: 10.3390/biom15070934 PMID: 40723805

10

Mining Thermophile Genomes for New PETases with Exceptional Thermostabilities Using Sequence Similarity Networks.

Hu Z, Klupt K, Zechel DL, Jia Z, Howe G

Chembiochem : a European journal of chemical biology2025

DOI: 10.1002/cbic.202500065 PMID: 40069109

Protein Modification: From Monophosphate to Polyphosphate

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Jia, Zongchao

Keywords: polyphosphate; histidine polyphosphate modification; lysine polyphosphate modification; post-translational modification; biochemistry; biophysics; cell biology; protein regulation

$47,000

Developing a new class of P. aeruginosa antivirulence drug using a novel microsensor and electrokinetics technology

Principal investigatorSSHRC2021New Frontiers in Research Fund - Exploration

Principal investigators: Jia, Zongchao

Keywords: drug design, infection microsensor electrokinetics inhibitor screening antivirulence

$250,000

STRUCTURAL AND FUNCTIONAL INSIGHTS INTO ALPHA-KINASES AND THEIR REGULATION

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Jia, Zongchao

$414,000

Centrifuge suite for protein structure/function studies

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Smith, Steven

$149,390

Canada Research Chair - Tier 1

Nominated PICIHR2017Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Jia, Zongchao

Keywords: Crc

$1,400,000

Shaker incubators for cultivation of bacteria

Co-investigatorNSERC2015Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Zechel, David

$99,274

Monitoring Biomolecular Interactions using Isothermal Titration Calorimetry

Principal investigatorNSERC2013Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Jia, Zongchao

$118,094

Structural and functional insights into alpha-kinases and their regulation

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Jia, Zongchao

$345,000

Analytical Ultracentrifugation of Biomolecules and Macromolecular Complexes

Co-investigatorNSERC2012Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Smith, Steven

$42,786

Structure and Function of E. coli Tyrosine Kinase: a Regulator of Capsule Development and Antibiotic Resistance in Gram-Negative Bacterial Pathogens

SupervisorCIHR2012Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Chesterman, Chelsy C

Keywords: Antibiotic Resistance; Bacterial Pathogens; Computational Modelling; In Vivo Functional Assays; Membrane Proteins; Pharmaceutical Design; Prokaryotic Tyrosine Kinases; Protein Interactions; Protein Structure And Function; X-Ray Crystallography

$70,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biomedical and Molecular Sciences
Pathology and Molecular Medicine
Cellular and Molecular Medicine
Biology
Chemistry
Psychiatry & Behavioural Neurosciences
Other

Co-authors at Queen's University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Keith Poole

Biomedical and Molecular Sciences

3 shared papers, latest 2025

Xiaolong Yang

Pathology and Molecular Medicine

3 shared papers, latest 2026

Michael Downey

Cellular and Molecular Medicine

2 shared papers, latest 2024

Shetuan Zhang

Biomedical and Molecular Sciences

2 shared papers, latest 2015

Karine Auclair

Chemistry

1 shared papers, latest 2023

Yongjun Lai

Faculty

1 shared papers, latest 2025

Ian Chin Sang

Biology

1 shared papers, latest 2014

Roderick Macleod

Psychiatry & Behavioural Neurosciences

1 shared papers, latest 2008

Lidan You

Faculty

1 shared papers, latest 2025

Glenville Jones

Faculty

1 shared papers, latest 2006

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: Crc Dear Professor Jia, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Polyphosphate as a novel regulator of super-enhancer complexes: disruption of phase separation and gene expression." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Protein Modification: From Monophosphate to Polyphosphate" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]