Neil Renwick, Queen's University

Research

neuroendocrine neoplasms post-transcriptional gene regulation microRNAs RNA-binding proteins RNA targeting deep learning graph neural networks data representation molecular classification

Latest papers

YAP and TEAD Are Transcriptional Regulators of Neuroendocrine Differentiation and Growth in Carcinoid Cells.
The American journal of pathology · 2026 · senior author
Circular RNA Profiling Identifies circ5078 as a BMPR2-Derived Regulator of Endothelial Proliferation and Stress Responses.
Arteriosclerosis, thrombosis, and vascular biology · 2025
Deep sequencing reveals distinct microRNA-mRNA signatures that differentiate pancreatic neuroendocrine tumor from non-diseased pancreas tissue.
BMC cancer · 2025

All 19 publications

Latest funding

Elucidating the role extracellular vesicles play in leukaemogenesis
CIHR · 2020 · Co-investigator
$1,071,000
Advancing knowledge of highly heterogeneous neuroendocrine neoplasms through graph neural network modeling of post-transcriptional gene regulatory networks
SSHRC · 2020 · Principal investigator
$249,512
Exploring microRNA biomarkers and mechanisms of disease in neuroendocrine neoplasms
CIHR · 2020 · Supervisor
$105,000

All 3 grants and awards

19 publications.

01

YAP and TEAD Are Transcriptional Regulators of Neuroendocrine Differentiation and Growth in Carcinoid Cells.

Nanayakkara J, Yang X, Damiani S, Imtiaz T, Wang X, Anastasakis DG, Shah GM, Tyryshkin K, Hafner M, Yang X, Renwick N

The American journal of pathology2026Senior author

DOI: 10.1016/j.ajpath.2025.10.012 PMID: 41274341

02

Circular RNA Profiling Identifies circ5078 as a BMPR2-Derived Regulator of Endothelial Proliferation and Stress Responses.

VandenBroek MM, Sharp MC, Thompson P, Fagbola E, Quilty D, Mewburn JD, Theilmann AL, Dunham-Snary KJ, Hemnes AR, Cogan JD, Austin ED, Hamid R, Archer SL, Renwick N, Ormiston ML

Arteriosclerosis, thrombosis, and vascular biology2025

DOI: 10.1161/atvbaha.124.322455 PMID: 40772817

03

Deep sequencing reveals distinct microRNA-mRNA signatures that differentiate pancreatic neuroendocrine tumor from non-diseased pancreas tissue.

Matyasovska N, Valkova N, Gala M, Bendikova S, Abdulhamed A, Palicka V, Renwick N, Čekan P, Paul E

BMC cancer2025

DOI: 10.1186/s12885-025-14043-w PMID: 40217502

04

A user-driven machine learning approach for RNA-based sample discrimination and hierarchical classification.

Imtiaz T, Nanayakkara J, Fang A, Jomaa D, Mayotte H, Damiani S, Javed F, Jones T, Kaczmarek E, Adebayo FO, Imtiaz U, Li Y, Zhang R, Mousavi P, Renwick N, Tyryshkin K

STAR protocols2023

DOI: 10.1016/j.xpro.2023.102661 PMID: 39491552

05

A transcriptome analysis of basal and stimulated VWF release from endothelial cells derived from patients with type 1 VWD.

Kloosterman R, Zago-Schmitt M, Grabell J, Thibeault L, De Lima PA, Bowman M, Tyryshkin K, Hindmarch CCT, Renwick N, James P

Blood advances2023

DOI: 10.1182/bloodadvances.2022007884 PMID: 36121439

06

A Computational Approach to Identification of Candidate Biomarkers in High-Dimensional Molecular Data.

Gerolami J, Wong JJM, Zhang R, Chen T, Imtiaz T, Smith M, Jamaspishvili T, Koti M, Glasgow JI, Mousavi P, Renwick N, Tyryshkin K

Diagnostics (Basel, Switzerland)2022

DOI: 10.3390/diagnostics12081997 PMID: 36010347

07

Emerging Evidence of Noncoding RNAs in Bleb Scarring after Glaucoma Filtration Surgery.

Yu S, Tam ALC, Campbell R, Renwick N

Cells2022Senior author

DOI: 10.3390/cells11081301 PMID: 35455980

08

Discriminating Neoplastic from Nonneoplastic Tissues Using an miRNA-Based Deep Cancer Classifier.

Kaczmarek E, Pyman B, Nanayakkara J, Tuschl T, Tyryshkin K, Renwick N, Mousavi P

The American journal of pathology2022

DOI: 10.1016/j.ajpath.2021.10.012 PMID: 34774515

09

Topology preserving stratification of tissue neoplasticity using Deep Neural Maps and microRNA signatures.

Kaczmarek E, Nanayakkara J, Sedghi A, Pesteie M, Tuschl T, Renwick N, Mousavi P

BMC bioinformatics2022

DOI: 10.1186/s12859-022-04559-4 PMID: 35026982

10

Multi-Omic Graph Transformers for Cancer Classification and Interpretation.

Kaczmarek E, Jamzad A, Imtiaz T, Nanayakkara J, Renwick N, Mousavi P

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing2022

PMID: 34890164

Elucidating the role extracellular vesicles play in leukaemogenesis

Co-investigatorCIHR2020Project Grant

Principal investigators: Abraham, Sheela A

Keywords: Chronic Myeloid Leukaemia; Clonal Haematopoiesis; Extracellular Vesicles; Haematopoietic Stem Cells; Leukaemia

$1,071,000

Advancing knowledge of highly heterogeneous neuroendocrine neoplasms through graph neural network modeling of post-transcriptional gene regulatory networks

Principal investigatorSSHRC2020New Frontiers in Research Fund - Exploration

Principal investigators: Renwick, Neil

Keywords: neuroendocrine neoplasms post-transcriptional gene regulation microRNAs RNA-binding proteins RNA targeting deep learning graph neural networks data representation molecular classification

$249,512

Exploring microRNA biomarkers and mechanisms of disease in neuroendocrine neoplasms

SupervisorCIHR2020Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Nanayakkara, Jinadari

Keywords: Biomarker Development; Chip-Sequencing; Graph Theory; Microrna; Molecular Mechanisms; Network Models; Neuroendocrine Neoplasms; Post-Transcriptional Gene Regulation; Rna-Based Therapeutics; Rna-Sequencing

$105,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

School of Computing
Cell biology
Biomedical and Molecular Sciences
Ophthalmology
Other

Co-authors at Queen's University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Kathrin Tyryshkin

Faculty

11 shared papers, latest 2026

Parvin Mousavi

School of Computing

6 shared papers, latest 2023

Xiaolong Yang

Cell biology

2 shared papers, latest 2026

Paula James

Faculty

1 shared papers, latest 2023

Madhuri Koti

Biomedical and Molecular Sciences

1 shared papers, latest 2022

Robert Campbell

Ophthalmology

1 shared papers, latest 2022

Simron Singh

Faculty

1 shared papers, latest 2020

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their SSHRC grant from 2020

Subject: Prospective PhD student: neuroendocrine neoplasms post-transcriptional gene regulation microRNAs RNA-binding proteins RNA targeting deep learning graph neural networks data representation molecular classification Dear Professor Renwick, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "YAP and TEAD Are Transcriptional Regulators of Neuroendocrine Differentiation and Growth in Carcinoid Cells." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your SSHRC-funded project "Advancing knowledge of highly heterogeneous neuroendocrine neoplasms through graph neural network modeling of post-transcriptional gene regulatory networks" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]