Xiaolong Yang, Queen's University

Research

Metastasis Signal Transduction Breast Cancer Hippo Pathway Biomarker Grep1 Integrin Noncanonical Open Reading Frame

Latest papers

Microproteins as a Hidden Player in Breast Cancer: From Molecular Insights to Therapeutic Potential.
Cell biochemistry and function · 2026
N-Myristoyltransferase 2 Is Regulated by Polyphosphate-Driven Lysine Interactions.
Biomolecules · 2026
YAP and TEAD Are Transcriptional Regulators of Neuroendocrine Differentiation and Growth in Carcinoid Cells.
The American journal of pathology · 2026

All 59 publications

Latest funding

Investigating the Role of GREP1 in Breast Cancer Metastasis and Therapy
CIHR · 2026 · Nominated PI
$1,266,076
Characterization of PTPN12 as a novel regulator of the Hippo pathway in breast cancer metastasis
CIHR · 2022 · Nominated PI
$60,000
Investigating the PTK-Hippo axis in breast cancer metastasis
CIHR · 2022 · Nominated PI
$956,250

All 8 grants and awards

59 publications.

01

Microproteins as a Hidden Player in Breast Cancer: From Molecular Insights to Therapeutic Potential.

Dai Q, Seaman K, Song X, Sassi A, Yang X, You L

Cell biochemistry and function2026

DOI: 10.1002/cbf.70305 PMID: 42726509

02

N-Myristoyltransferase 2 Is Regulated by Polyphosphate-Driven Lysine Interactions.

Martins I, Bailey K, Ge A, Belrose E, Yang X, Jia Z

Biomolecules2026

DOI: 10.3390/biom16081096 PMID: 42650764

03

YAP and TEAD Are Transcriptional Regulators of Neuroendocrine Differentiation and Growth in Carcinoid Cells.

Nanayakkara J, Yang X, Damiani S, Imtiaz T, Wang X, Anastasakis DG, Shah GM, Tyryshkin K, Hafner M, Yang X, Renwick N

The American journal of pathology2026

DOI: 10.1016/j.ajpath.2025.10.012 PMID: 41274341

04

Gain-of-Functional Genomic Screening for Microproteins Essential for Tumorigenesis.

Ge A, Gao Y, Yang X

Methods in molecular biology (Clifton, N.J.)2026Senior author

DOI: 10.1007/978-1-0716-5013-4_17 PMID: 41241911

05

Alexidine is a TAZ-specific small-molecule inhibitor that suppresses breast cancer invasion and metastasis.

Ge A, Niu L, Rubino R, Seaman K, Song X, Hao Y, Klupt K, Iaboni N, Jia Z, You L, Nicol CJB, Fu H, Du Y, Yang X

iScience2025Senior author

DOI: 10.1016/j.isci.2025.114116 PMID: 41438036

06

Kinome-Wide Screening Identifies FAK as a Novel Post-Translational Regulator of PD-L1 Stability and Immune Evasion in Triple-Negative Breast Cancer.

Boyd AL, Khanal P, Kelly T, Ge A, Hao Y, Yang X

International journal of molecular sciences2025Senior author

DOI: 10.3390/ijms262010108 PMID: 41155402

07

Application of Fluorescence- and Bioluminescence-Based Biosensors in Cancer Drug Discovery.

Kelly T, Yang X

Biosensors2024Senior author

DOI: 10.3390/bios14120570 PMID: 39727835

08

A Novel Bioluminescent Biosensor Quantifying Intramolecular Interaction and Levels of Pyroptosis Effector GSDMD.

Kelly T, Bhandari S, Carew M, Rubino R, Nicol C, Yang X

Cells2024Senior author

DOI: 10.3390/cells13191606 PMID: 39404370

09

Exploring the Dark Matter of Human Proteome: The Emerging Role of Non-Canonical Open Reading Frame (ncORF) in Cancer Diagnosis, Biology, and Therapy.

Ge A, Chan C, Yang X

Cancers2024Senior author

DOI: 10.3390/cancers16152660 PMID: 39123386

10

Identification of PTPN12 Phosphatase as a Novel Negative Regulator of Hippo Pathway Effectors YAP/TAZ in Breast Cancer.

Sarmasti Emami S, Ge A, Zhang D, Hao Y, Ling M, Rubino R, Nicol CJB, Wang W, Yang X

International journal of molecular sciences2024Senior author

DOI: 10.3390/ijms25074064 PMID: 38612874