This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Queen's University directory, so their courses and email address may be missing. Find their university profile.
Research
Latest papers
Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies.
Nature communications · 2023
Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.
JCI insight · 2020
Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy.
American journal of physiology. Cell physiology · 2020
Latest funding
- $140,000
Development of calpain inhibitors to suppress breast cancer metastasis
CIHR · 2025 · Supervisor
- $956,250
Investigating the PTK-Hippo axis in breast cancer metastasis
CIHR · 2022 · Co-investigator
- $105,000
Enhancing Anti-Cancer Immunotherapy by Disruption of the non-Receptor Tyrosine Kinase Fes
CIHR · 2022 · Supervisor
4 publications.
Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies.
Azad T, Rezaei R, Singaravelu R, Pelin A, Boulton S, Petryk J, Onsu KA, Martin NT, Hoskin V, Ghahremani M, Marotel M, Marius R, He X, Crupi MJF, Hoang HD, Nik-Akhtar A, Ahmadi M, Zamani NK, Golshani A, Alain T, Greer P, Ardolino M, Dickinson BC, Tai LH, Ilkow CS, Bell JC
Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.
Tian X, Inoue K, Zhang Y, Wang Y, Sperati CJ, Pedigo CE, Zhao T, Yan M, Groener M, Moledina DG, Ebenezer K, Li W, Zhang Z, Liebermann DA, Greene L, Greer P, Parikh CR, Ishibe S
Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy.
Piper AK, Sophocleous RA, Ross SE, Evesson FJ, Saleh O, Bournazos A, Yasa J, Reed C, Woolger N, Sluyter R, Greer P, Biro M, Lemckert FA, Cooper ST
N-acylation of glucosamine modulates chondrocyte growth, proteoglycan synthesis, and gene expression.
Terry DE, Rees-Milton K, Smith P, Carran J, Pezeshki P, Woods C, Greer P, Anastassiades TP
Development of calpain inhibitors to suppress breast cancer metastasis
Principal investigators: Shapovalov, Ivan
Keywords: Breast Cancer; Calpain; Calpain Inhibitor; Drug Discovery; High Throughput Screening; Medicinal Chemistry; Metastasis; Protease; Structure-Activity Relationship; Triple Negative Breast Cancer
Investigating the PTK-Hippo axis in breast cancer metastasis
Principal investigators: Yang, Xiaolong
Keywords: Breast Cancer; Cell Migration And Invasion; Combination Therapy; Hippo Pathway; Kinases; Metastasis; Protein Tyrosine Kinases; Signal Transduction; Targeted Therapy; Xenograft Mouse Model
Enhancing Anti-Cancer Immunotherapy by Disruption of the non-Receptor Tyrosine Kinase Fes
Principal investigators: Laight, Brian
Keywords: Cancer Immunotherapy; Cell Biology; Genetic Modulation; Immune Checkpoint Inhibitors; Innate Immunology
Abrogating triple negative breast cancer metastasis through inhibition of calpain protease
Principal investigators: Shapovalov, Ivan
Keywords: Animal Model; Breast Cancer; Calpain; Calpain Inhibitor; Capn; Cell Motility; Experimental Metastasis; High Throughput Screening; Triple Negative Breast Cancer
Targeting the calpain protease in breast cancer
Principal investigators: Greer, Peter A
Keywords: Breast Cancer; Calpain Protease; Metastasis; Signal Transduction; Transgenic Mouse Models; Xenograft Mouse Models
Calpain as a novel therapeutic target in breast cancer
Principal investigators: Greer, Peter A
Keywords: Breast Cancer; Calpain Protease; Metastasis; Signal Transduction; Transgenic Mouse Models; Xenograft Mouse Models
Development of a biosensor for high throughput screening of novel compounds targeting ezrin for breast cancer therapy
Principal investigators: Greer, Peter A
Keywords: Development Of A Biosensor
FER as a novel therapeutic target in breast cancer
Principal investigators: Greer, Peter A
Keywords: Breast Cancer; Inhibitors; Metastasis; Preclinical Models; Protein Tyrosine Kinases; Signal Transduction
FER as a novel therapeutic target in breast cancer
Principal investigators: Greer, Peter A
Keywords: Anoikis; Cancer; Fer Tyrosine Kinase; Metastasis; Preclinical Models; Xenograft
Identifying substrates of the calpain protease system and elucidating the role of calpain in the cancer cell signalling network
Principal investigators: Grieve, Stacy
Keywords: Calpain; Mouse Xenograph Models; Protease Substrate; Proteomics; Targeted Therapies
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Biochemistry, Microbiology and Immunology
- Cancer Research Institute
- Immunology
- Microbiology and Infectious Diseases
Co-authors at Queen's University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Michele Ardolino
Biochemistry, Microbiology and Immunology
1 shared papers, latest 2023
Tommy Alain
Biochemistry, Microbiology and Immunology
1 shared papers, latest 2023
Taha Azad
Microbiology and Infectious Diseases
1 shared papers, latest 2023
Abolfazl Nik-Akhtar
Biochemistry, Microbiology and Immunology
1 shared papers, latest 2023
Lee-Hwa Tai
Immunology
1 shared papers, latest 2023
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