Faculty profile

Michele Ardolino

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Assistant ProfessorBiochemistry, Microbiology and ImmunologyUniversity of Ottawa

Michele Ardolino

Assistant Professor

Biochemistry, Microbiology and Immunology

Faculty of Medicine

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
20 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (5 CIHR, 2 NSERC, 1 SSHRC), most recently in 2024.
Supervisor on 4 trainee awards (4 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Ottawa profile.

Tumor Immunology Innate Immunity Nk Cells Immunotherapy Cancer Immunotherapy Pd-1 Collaborative Networking Immunology

Latest papers

Natural Killer Cell-Derived Extracellular Vesicles Exhibit Cytotoxicity Against Bulk Tumor Cells and Cancer Stem Cells in Triple-Negative Breast Cancer.
Nanomaterials (Basel, Switzerland) · 2026
ILC2s in cancer: good, bad, or stay tuned?
Trends in molecular medicine · 2026 · senior author
Multimeric Branched and Hyperbranched Peptide Ligands of the Natural Cytotoxicity Receptor NKp30 on Natural Killer Cells.
Bioconjugate chemistry · 2026

All 29 publications

Latest funding

Identifying CD8 T Cell Immunometabolic Scars in Chronic HCV and Metabolic Liver Disease and Their Impact on HCC Responses
CIHR · 2025 · Co-investigator
$1,296,676
ILC6 - The 6th International Conference on Innate Lymphoid Cells
CIHR · 2025 · Co-investigator
$10,000
Harnessing IL-33 and Checkpoint Blockade to Boost Adaptive Immunity in Ovarian Cancer
CIHR · 2025 · Supervisor
$120,000

All 18 grants and awards

29 publications.

Natural Killer Cell-Derived Extracellular Vesicles Exhibit Cytotoxicity Against Bulk Tumor Cells and Cancer Stem Cells in Triple-Negative Breast Cancer.

Kirkby M, St-Denis-Bissonnette F, Diab MD, Mediratta K, Korobkow A, Humber J, Han P, Muradia G, Ardolino M, Lee SH, Gibbings DJ, Burger D, Wang L, Lavoie JR

Nanomaterials (Basel, Switzerland)2026

DOI: 10.3390/nano16090525 PMID: 42117942

ILC2s in cancer: good, bad, or stay tuned?

Asif S, Kinzel M, Vanderhyden B, Jacquelot N, Ardolino M

Trends in molecular medicine2026Senior author

DOI: 10.1016/j.molmed.2025.06.010 PMID: 40651913

Multimeric Branched and Hyperbranched Peptide Ligands of the Natural Cytotoxicity Receptor NKp30 on Natural Killer Cells.

Allen MC, Collak FK, Daniel G, Leblanc M, Kurdieh R, Ardolino M, Biggar KK, Sabatino D

Bioconjugate chemistry2026

DOI: 10.1021/acs.bioconjchem.5c00512 PMID: 41550046

Preventing surgery-induced natural killer cell suppression and metastases by inhibiting PI3K-gamma signaling in myeloid-derived suppressor cells.

Angka L, Tennakoon G, Cook DP, Martel AB, Market M, Tanese de Souza C, Cummins E, Samudio I, Kekre N, Ardolino M, Vanderhyden BC, Kennedy MA, Auer RC

Journal for immunotherapy of cancer2026

DOI: 10.1136/jitc-2025-013304 PMID: 41611243

Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity.

St-Denis-Bissonnette F, Mediratta K, Ho N, Kirkby M, Stalker A, Muradia G, Shrestha A, Ardolino M, Lee SH, Burger D, Mer A, Wang L, Lavoie JR

Molecular therapy. Oncology2026

DOI: 10.1016/j.omton.2026.201261 PMID: 42383255

Efficacy of chimeric antigen receptor engineered natural killer cells in the treatment of hematologic malignancies: a systematic review and meta-analysis of preclinical studies

Bastin DJ, Kilgour MK, Shorr R, Sabri E, Delluc A, Ardolino M, McComb S, Lee S-H, Allan D, Ramsay T

Cytotherapy20256 citations

DOI: 10.1016/j.jcyt.2024.11.004

LAG3 Marks Activated but Hyporesponsive NK Cells.

Vasilyeva V, Makinson O, Chan C, Park M, O'Dwyer C, Ali A, Khan AUH, de Souza CT, Hasim MS, Asif S, Kurdieh R, Abou-Hamad J, Yakubovich E, Hodgins J, Haddad PA, Pietropaolo G, Mazej J, Seo H, Huang Q, Nersesian S, Chay D, Jacquelot N, Cook D, Lee SH, Sciumè G, Waggoner S, Ardolino M, Marotel M

European journal of immunology2025

DOI: 10.1002/eji.70009 PMID: 40705324

Feeling exhausted, no longer - macrophages keep type 2 innate lymphoid cells energized.

Kinzel M, Ibrahim D, Ardolino M, Jacquelot N

Cellular & molecular immunology2025

DOI: 10.1038/s41423-025-01362-y PMID: 41145901

CD8 T Cell Hyperfunction and Reduced Tumour Control in Murine Models of Advanced Liver Disease.

Madani J, Li J, Ching MEA, Vranjkovic A, Jorritsma K, Hasim MS, Daneshmand M, Campeau N, Lawton DA, Bagheri S, Cheung AC, Mulvihill EE, Bruin JE, Ardolino M, Crawley AM

European journal of immunology2025

DOI: 10.1002/eji.70026 PMID: 40760842

The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors.

Bergin CJ, Zouggar A, Mendes da Silva A, Fenouil T, Haebe JR, Masibag AN, Agrawal G, Shah MS, Sandouka T, Tiberi M, Auer RC, Ardolino M, Benoit YD

Nature cancer2024

DOI: 10.1038/s43018-024-00727-y PMID: 38351181

Identifying CD8 T Cell Immunometabolic Scars in Chronic HCV and Metabolic Liver Disease and Their Impact on HCC Responses

Co-investigatorCIHR2025Project Grant

Principal investigators: Crawley, Angela M

Keywords: Cd8 T Cells; Chronic Hepatitis C Virus Infection; Cytolytic Function; Fatty Liver Disease; Human; Liver Cancer; Liver Fibrosis; Murine

$1,296,676

ILC6 - The 6th International Conference on Innate Lymphoid Cells

Co-investigatorCIHR2025Planning and Dissemination Grant - Institute Community Support

Principal investigators: Mortha, Arthur

Keywords: Immunology

$10,000

Harnessing IL-33 and Checkpoint Blockade to Boost Adaptive Immunity in Ovarian Cancer

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Ibrahim, Dalia K

Keywords: Checkpoint Blockade; Immune System; Immunotherapy; Mouse Models; Ovarian Cancer; Spatial Transcriptomics; Tumor Microenvironment

$120,000

A mechanistic investigation of NK cell disarming.

Nominated PICIHR2024Project Grant

Principal investigators: Ardolino, Michele

Keywords: Immune Dysfunction; Nk Cells; Tumor Immunology

$906,525

2024 Canadian-Natural Killer Cell Consortium annual symposium: Contract killers for human health.

Nominated PICIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Ardolino, Michele

Keywords: Cancer Immunotherapy; Collaborative Networking; Immunology; Industry; Infectious Diseases; Innate Immunity; Nk Cells; Student Researchers; Transplantation; Vaccines

$20,000

Harnessing ILC2 for immunotherapy of ovarian cancer.

Nominated PICIHR2024Project Grant

Principal investigators: Ardolino, Michele

Keywords: Immunotherapy; Innate Immunity; Innate Lymphoid Cells; Oncolytic Viruses; Ovarian Cancer; Tumor Immunology

$1,005,975

Overcoming barriers to effective cancer immunotherapy with an engineered virus based therapeutic

Co-investigatorCIHR2023Project Grant

Principal investigators: Bell, John C

Keywords: Cancer; Engineering; Extracellular Matrix; Immune Activation; Immune Evasion; Inducible Promoters; Oncolytic Virus; T Cell Engager; T Cells

$100,000

Targeting cancer-like endothelial cell growth in Pulmonary Arterial Hypertension using CAR-NK cell therapy.

Principal investigatorSSHRC2023New Frontiers in Research Fund - Exploration

Principal investigators: Ardolino, Michele

Keywords: CAR NK cells; Pulmonary Arterial Hypertension; Senescence; TM4SF1; Endothelial Cells

$250,000

Overcoming barriers to effective cancer immunotherapy with an engineered virus based therapeutic

Co-investigatorCIHR2023Project Grant

Principal investigators: Bell, John C

Keywords: Cancer; Engineering; Extracellular Matrix; Immune Activation; Immune Evasion; Inducible Promoters; Oncolytic Virus; T Cell Engager; T Cells

$1,047,500

Not just an army: the role of innate lymphoid cells in mammalian ovulation

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Asif, Sara

Keywords: Cytokine; Female Reproductive System; Immunology; Inflammation; Innate Lymphoid Cells; Natural Killer Cells; Ovarian Cancer; Single-Cell Transcriptomics; Women'S Health

$105,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Michele Ardolino

Research

Latest papers

Latest funding

Natural Killer Cell-Derived Extracellular Vesicles Exhibit Cytotoxicity Against Bulk Tumor Cells and Cancer Stem Cells in Triple-Negative Breast Cancer.

ILC2s in cancer: good, bad, or stay tuned?

Multimeric Branched and Hyperbranched Peptide Ligands of the Natural Cytotoxicity Receptor NKp30 on Natural Killer Cells.

Preventing surgery-induced natural killer cell suppression and metastases by inhibiting PI3K-gamma signaling in myeloid-derived suppressor cells.

Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity.

Efficacy of chimeric antigen receptor engineered natural killer cells in the treatment of hematologic malignancies: a systematic review and meta-analysis of preclinical studies

LAG3 Marks Activated but Hyporesponsive NK Cells.

Feeling exhausted, no longer - macrophages keep type 2 innate lymphoid cells energized.

CD8 T Cell Hyperfunction and Reduced Tumour Control in Murine Models of Advanced Liver Disease.

The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors.

Targeting cancer-like endothelial cell growth in Pulmonary Arterial Hypertension using CAR-NK cell therapy.

Frequent collaborators

Seung-Hwan Lee

Lisheng Wang

Nicolas Jacquelot

Dylan Burger

Jean-Simon Diallo

Alissa Visram

Marie-Claude Bourgeois-Daigneault

Joel Werier

Natasha Kekre

Taha Azad

Arvind Mer

David Cook

Abolfazl Nik-Akhtar

Arleigh McCurdy

Tommy Alain

David Allan

Andrzej Chruscinski

Lee-Hwa Tai

Peter Greer

Mario Tiberi

Mary-Ellen Harper

Barbara Vanderhyden