Byram Bridle, University of Guelph

Research

Osteosarcoma Lung Metastases Combining Oncolytic Virotherapy And Epigenetic Modifiers

Latest papers

Variation in ovine serum vitamin D concentrations from late summer to early spring and during immune challenge with bacterial endotoxin.
Veterinary immunology and immunopathology · 2025
Correction: Karrow et al. Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development. Vaccines 2021, 9, 1351.
Vaccines · 2022
Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development.
Vaccines · 2021

All 9 publications

Latest funding

Calming the Cytokine Storm: Elucidating Mechanisms Contributing to Toxic Inflammatory Responses to Viruses
NSERC · 2021 · Principal investigator
$128,000
Development of an AAV gene therapy approach for the treatment of surfactant protein B deficiency
CIHR · 2019 · Co-investigator
$474,300
Vascular normalization improves immunotherapy in advanced stage ovarian cancer.
CIHR · 2019 · Co-investigator
$631,126

All 9 grants and awards

9 publications.

01

Variation in ovine serum vitamin D concentrations from late summer to early spring and during immune challenge with bacterial endotoxin.

Randle S, Wagter-Lesperance L, Dixon S, Shandilya UK, Mallard BA, Bridle B, Karrow NA

Veterinary immunology and immunopathology2025

DOI: 10.1016/j.vetimm.2024.110856 PMID: 39579673

02

Correction: Karrow et al. Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development. Vaccines 2021, 9, 1351.

Karrow NA, Shandilya UK, Pelech S, Wagter-Lesperance L, McLeod D, Bridle B, Mallard BA

Vaccines2022

DOI: 10.3390/vaccines10111925 PMID: 36423074

03

Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development.

Karrow NA, Shandilya UK, Pelech S, Wagter-Lesperance L, McLeod D, Bridle B, Mallard BA

Vaccines2021

DOI: 10.3390/vaccines9111351 PMID: 34835282

04

Transcriptomics of chicken cecal tonsils and intestine after infection with low pathogenic avian influenza virus H9N2.

Alqazlan N, Emam M, Nagy É, Bridle B, Sargolzaei M, Sharif S

Scientific reports2021

DOI: 10.1038/s41598-021-99182-3 PMID: 34650121

05

Probiotic Lactobacilli Enhance Immunogenicity of an Inactivated H9N2 Influenza Virus Vaccine in Chickens.

Alqazlan N, Astill J, Taha-Abdelaziz K, Nagy É, Bridle B, Sharif S

Viral immunology2021

DOI: 10.1089/vim.2020.0209 PMID: 33236974

06

Probiotic Lactobacilli Limit Avian Influenza Virus Subtype H9N2 Replication in Chicken Cecal Tonsil Mononuclear Cells.

Alqazlan N, Alizadeh M, Boodhoo N, Taha-Abdelaziz K, Nagy E, Bridle B, Sharif S

Vaccines2020

DOI: 10.3390/vaccines8040605 PMID: 33066282

07

Characterization of the Impact of Oncolytic Vesicular Stomatitis Virus on the Trafficking, Phenotype, and Antigen Presentation Potential of Neutrophils and Their Ability to Acquire a Non-Structural Viral Protein

Stegelmeier AA, Chan L, Mehrani Y, Petrik JJ, Wootton SK, Bridle B, Karimi K

International Journal of Molecular Sciences202016 citations

DOI: 10.3390/ijms21176347

08

Replication and Oncolytic Activity of an Avian Orthoreovirus in Human Hepatocellular Carcinoma Cells.

Kozak RA, Hattin L, Biondi MJ, Corredor JC, Walsh S, Xue-Zhong M, Manuel J, McGilvray ID, Morgenstern J, Lusty E, Cherepanov V, McBey BA, Leishman D, Feld JJ, Bridle B, Nagy É

Viruses2017

DOI: 10.3390/v9040090 PMID: 28441762

09

Analysis of gene expression patterns by microarray hybridization in blood mononuclear cells of SLA-DRB1 defined Canadian Yorkshire pigs.

Nino-Soto MI, Jozani RJ, Bridle B, Mallard BA

BMC research notes2008

DOI: 10.1186/1756-0500-1-31 PMID: 18710484

Calming the Cytokine Storm: Elucidating Mechanisms Contributing to Toxic Inflammatory Responses to Viruses

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Bridle, Byram

$128,000

Development of an AAV gene therapy approach for the treatment of surfactant protein B deficiency

Co-investigatorCIHR2019Project Grant

Principal investigators: Wootton, Sarah

Keywords: Acute Respiratory Distress; Adeno-Associated Virus; Alveolar Type Ii Cells; Gene Therapy; Monogenic Lung Disease; Surfactant Protein B Deficiency

$474,300

Vascular normalization improves immunotherapy in advanced stage ovarian cancer.

Co-investigatorCIHR2019Project Grant

Principal investigators: Petrik, Jim J

Keywords: Advanced Stage Disease; Combination Therapy; Immunotherapy; Metronomic Chemotherapy; Ovarian Cancer; Pdx Models Of Ovarian Cancer; Translational Ovarian Cancer Research; Tumor Immunosuppression; Vascular Normalization

$631,126

Treatment of Osteosarcoma Lung Metastases with an Infected Cancer Cell Vaccine.

Nominated PICIHR2018CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Bridle, Byram W

Keywords: Osteosarcoma Lung Metastases

$60,000

Combining oncolytic virotherapy and epigenetic modifiers to treat acute leukemias

Nominated PICIHR2018Operating Grant: CCS Innovation Grants

Principal investigators: Bridle, Byram W

Keywords: Combining Oncolytic Virotherapy And Epigenetic Modifiers

$100,000

Maintaining Ultracentrifugation Capacity for Biological Research at the Ontario Veterinary College

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Wootton, Sarah

$148,224

Replacement of a core facility's heavily-used, 22-year-old analytical flow cytometer for which parts and service are no longer guaranteed.

Principal investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Bridle, Byram

$103,249

Type I interferon receptor signalling as a master switch for the negative regulation of cytokine networks.

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Bridle, Byram

$210,000

Upgrade to state-of-the-art flow cytometric equipment

Co-investigatorNSERC2013Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Plattner, Brandon

$148,230

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Obstetrics & Gynecology
Other

Co-authors at University of Guelph, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Shayan Sharif

Faculty

3 shared papers, latest 2021

James Petrik

Obstetrics & Gynecology

1 shared papers, latest 2020

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2021

Subject: Prospective PhD student: Osteosarcoma Lung Metastases Dear Professor Bridle, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Variation in ovine serum vitamin D concentrations from late summer to early spring and during immune challenge with bacterial endotoxin." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Calming the Cytokine Storm: Elucidating Mechanisms Contributing to Toxic Inflammatory Responses to Viruses" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]