Faculty profile
Siavash Vahidi
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Research
Latest papers
Elevated mitochondrial protein import in acute myeloid leukemia increases reliance on mitochondrial protease LONP1.
The Journal of clinical investigation · 2026
Structural and mechanistic basis of ubiquitous bacterial kinase signaling identifies PorX as a noncanonical substrate in Porphyromonas gingivalis.
The Journal of biological chemistry · 2026
A Universal Buffer System for Native LC-MS Analysis of Antibody-Based Therapeutics.
Journal of the American Society for Mass Spectrometry · 2026 · senior author
Latest funding
- $135,000
Targeting the Mycobacterial Proteasome System to Fight Antimicrobial-Resistant Tuberculosis
CIHR · 2023 · Supervisor
- $1,143,675
Developing allosteric inhibitors of mitochondrial ClpP protease for acute myeloid leukemia
CIHR · 2023 · Nominated PI
- $100,000
Development of boron-based inhibitors of the mitochondrial ClpXP protease to combat AML
CIHR · 2022 · Nominated PI
18 publications.
Elevated mitochondrial protein import in acute myeloid leukemia increases reliance on mitochondrial protease LONP1.
Tcheng M, Voisin V, Thomas GE, Piric AA, Gronda M, Hurren R, Ling D, Yan Y, Zhang LX, Feng Y, Chegini A, Duong N, Mancini RS, Currie SQW, Mamai Z, Stock B, Khan S, Jitkova Y, Sarathy C, Ayoub E, Mak PY, Arruda A, Kislinger T, Reed MA, Carter BZ, Andreeff M, Kornblau SM, Minden MD, Vahidi S, Schimmer AD
Structural and mechanistic basis of ubiquitous bacterial kinase signaling identifies PorX as a noncanonical substrate in Porphyromonas gingivalis.
Saran A, Yang Z, Wang Z, Harris JNC, Vahidi S, Zeytuni N
A Universal Buffer System for Native LC-MS Analysis of Antibody-Based Therapeutics.
Vosper KR, Davis BTV, Saraya J, O Flaherty DK, Velyvis A, Vahidi S
Catalytic Activity of Electrosprayed Enzyme Ions in the Gas Phase.
Ng YK, Currie SQW, Aliyari E, Cui C, Vahidi S, Konermann L
Characterization of Conformational Dynamics and Structural Plasticity of the Catalytic Domain of Human Mitochondrial YME1L Protease.
Black MK, Kim A, Chen CY, Goncalves MM, Waseem S, Vahidi S, Huang R
Structural heterogeneity and substrate engagement mechanism of the bacterial proteasome activator Bpa.
Davis BTV, Rennella E, Haris A, Ujma J, Bruton D, Richardson K, Giles K, Kay LE, Vahidi S
Molecular mechanisms of mitochondrial AAA+ proteases.
Currie SQW, Goncalves MM, Schimmer AD, Vahidi S
Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways.
Barghash MM, Mabanglo MF, Hoff SE, Brozdnychenko D, Wong KS, Binepal G, Ip P, Shen J, Furukawa T, Katayama H, Trudel V, Tan J, Yudin AK, Gray-Owen SD, Sakuda S, Batey RA, Vahidi S, Bonomi M, Houry WA
Allosteric regulation of proteolytic machines unveiled by the synergy between cryo-EM and solution NMR spectroscopy.
Turner M, Harkness RW, Ripstein ZA, Huang R, Vahidi S
HDgraphiX: A Web-Based Tool for Visualization of Hydrogen/Deuterium Exchange Mass Spectrometry Data.
Vosper KR, Velyvis A, Vahidi S
Targeting the Mycobacterial Proteasome System to Fight Antimicrobial-Resistant Tuberculosis
Principal investigators: Forrester, Taylor
Keywords: Antimicrobial Resistance; Cryogenic Electron Microscopy; Crystallography; Hydrogen Deuterium Exchange Mass Spectrometry; Mycobacterium Tuberculosis; Proteasome; Rational Design Of Therapeutics; Structural Biology; Tuberculosis Pandemic
Developing allosteric inhibitors of mitochondrial ClpP protease for acute myeloid leukemia
Principal investigators: Vahidi, Siavash; Schimmer, Aaron D; Zeytuni, Natalie
Keywords: Acute Myeloid Leukemia; Drug Discovery; In Vivo/In Vitro Biological Assays; Medicinal Chemistry; Mitochondrial Matrix Proteases; Structural Biology
Development of boron-based inhibitors of the mitochondrial ClpXP protease to combat AML
Principal investigators: Vahidi, Siavash; Yudin, Andrei
Keywords: Active Site Inhibitors; Acute Myeloid Leukemia; Blood Cancer; Drug Discovery; In Vivo/In Vitro Biological Assays; Libraries Of Small Molecules; Mitochondrial Matrix Proteases; Nmr Spectroscopy; Protein Degradation; Synthetic Chemistry
Deciphering the mechanisms underlying the operational plasticity of AAA+ motors
Principal investigators: Vahidi, Siavash
Deciphering the mechanisms underlying the operational plasticity of AAA+ motors
Principal investigators: Vahidi, Siavash
The Bhagirath Singh Early Career Prize in Infection and Immunity: Mechanisms of Allosteric Regulation of M. tuberculosis Proteasome Function
Principal investigators: Vahidi, Siavash
Keywords: Allostery; Functional Dynamics; Mass Spectrometry; Nmr Spectroscopy; Proteasome; Tuberculosis
Mechanisms of Allosteric Regulation of M. tuberculosis Proteasome Function
Principal investigators: Vahidi, Siavash
Keywords: Allostery; Functional Dynamics; Mass Spectrometry; Nmr Spectroscopy; Proteasome; Tuberculosis
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Siavash Vahidi and Natalie Zeytuni: 3 shared papers
- Jun Liu and Siavash Vahidi: 1 shared paper
- Brian Raught and Siavash Vahidi: 1 shared paper
- Molecular and Cellular Biology
- Anatomy and Biology
- Research Institute
- Molecular Genetics
Co-authors at University of Guelph, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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