Benjamin Rotstein

Research

Read how they describe their research on their University of Ottawa profile.

Atherosclerosis Carbon-11 Cardiovascular Imaging Fluorine-18 Inflammation Matrix Metalloproteinase Medicinal Chemistry Positron Emission Tomography

Latest papers

Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
Nanoengineered Sprayable Therapy for Treating Myocardial Infarction.
ACS nano · 2022
Correction to: Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021

All 5 publications

Latest funding

Manufacturing Protocol for a Fluorine-18 Protein Radiopharmaceutical Candidate
CIHR · 2025 · Supervisor
$6,000
Rapid discovery of molecular tracers through convergent carbon dioxide fixation chemistry
NSERC · 2024 · Principal investigator
$55,000
Development and Evaluation of Site Selective Annexin V Bioconjugates to Detect Apoptosis in Advanced Atherosclerosis
CIHR · 2023 · Supervisor
$105,000

All 8 grants and awards

5 publications.

01

Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy.

Wang JZ, Zelt JGE, Kaps N, Lavallee A, Renaud JM, Rotstein B, Beanlands RSB, Fallavollita JA, Canty JM, deKemp RA

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022

DOI: 10.1007/s12350-021-02732-5 PMID: 34341953

02

Nanoengineered Sprayable Therapy for Treating Myocardial Infarction.

Muñoz M, Eren Cimenci C, Goel K, Comtois-Bona M, Hossain M, McTiernan C, Zuñiga-Bustos M, Ross A, Truong B, Davis DR, Liang W, Rotstein B, Ruel M, Poblete H, Suuronen EJ, Alarcon EI

ACS nano2022

DOI: 10.1021/acsnano.1c08890 PMID: 35157804

03

Correction to: Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy.

Wang JZ, Zelt JGE, Kaps N, Lavallee A, Renaud JM, Rotstein B, Beanlands RSB, Fallavollita JA, Canty JM, deKemp RA

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021

DOI: 10.1007/s12350-021-02779-4 PMID: 34448095

04

First-in-human imaging and kinetic analysis of vesicular acetylcholine transporter density in the heart using [18F]FEOBV PET.

Saint-Georges Z, Zayed VK, Dinelle K, Cassidy C, Soucy JP, Massarweh G, Rotstein B, Nery PB, Guimond S, deKemp R, Tuominen L

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021

DOI: 10.1007/s12350-020-02323-w PMID: 32909238

05

Innate Immune Nod1/RIP2 Signaling Is Essential for Cardiac Hypertrophy but Requires Mitochondrial Antiviral Signaling Protein for Signal Transductions and Energy Balance.

Lin HB, Naito K, Oh Y, Farber G, Kanaan G, Valaperti A, Dawood F, Zhang L, Li GH, Smyth D, Moon M, Liu Y, Liang W, Rotstein B, Philpott DJ, Kim KH, Harper ME, Liu PP

Circulation2020

DOI: 10.1161/circulationaha.119.041213 PMID: 33070627

Manufacturing Protocol for a Fluorine-18 Protein Radiopharmaceutical Candidate

SupervisorCIHR2025Undergraduate Student Research Awards (USRA)

Principal investigators: Ghedam, Ezana

Keywords: Cell; Efferocytosis; Healthy Conditions; Inflammation; Membrane; Phosphatidylserine; Protein; Rats

$6,000

Rapid discovery of molecular tracers through convergent carbon dioxide fixation chemistry

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Rotstein, Benjamin

Keywords: radiochemistry; carbon-11; fluorine-18; tracer; medicinal chemistry; biochemical assays; cellular assays; imaging; positron emission tomography; carbon dioxide

$55,000

Development and Evaluation of Site Selective Annexin V Bioconjugates to Detect Apoptosis in Advanced Atherosclerosis

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Abdirahman, Faduma

Keywords: Atherosclerosis; Cardiac Health; Cell Death; Molecular Imaging; Radiochemistry

$105,000

Characterization of High-Risk Atherosclerosis with Selective Positron Emission Tomography Radiotracers for Matrix Metalloproteinase-13

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Buchler, Ariel

Keywords: Atherosclerosis; Autoradiography; Biodistribution And Metabolism; Enzyme Inhibition; Extracellular Matrix; Matrix Metalloproteinase; Medicinal Chemistry; Molecular Imaging; Positron Emission Tomography Imaging; Radiochemistry

$105,000

I2I Phase 1: Methods and Catalysts for Isotopic Labeling of Amino Acids

Co-investigatorNSERC2021Idea to Innovation

Principal investigators: Lundgren, Rylan

$125,000

Automated Peptide Synthesizer System for Accelerating discovery of Nanomaterials, Sensors, and Bioactive Compounds

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Alarcon, Emilio

$146,765

New approaches to carbon-11 labeled carbonyl and thiocarbonyl groups for positron emission tomography radiotracer synthesis and development

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Rotstein, Benjamin

$231,000

Selective imaging of matrix metalloproteinase-13 to identify vulnerable plaques in atherosclerosis

Nominated PICIHR2016Project Grant

Principal investigators: Rotstein, Benjamin

Keywords: Atherosclerosis; Carbon-11; Cardiovascular Imaging; Fluorine-18; Inflammation; Matrix Metalloproteinase; Medicinal Chemistry; Positron Emission Tomography; Radiotracer Development; Vulnerable Plaques

$462,523

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry, Microbiology and Immunology
Cellular and Molecular Medicine
Psychiatry
Institut de génie biomédical
Cardiac Surgery
Department of Medicine
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Wenbin Liang

Cellular and Molecular Medicine

2 shared papers, latest 2022

Jean-Paul Soucy

Institut de génie biomédical

1 shared papers, latest 2021

Lauri Tuominen

Faculty

1 shared papers, latest 2021

Synthia Guimond

Faculty

1 shared papers, latest 2021

Katie Dinelle

Faculty

1 shared papers, latest 2021

Zacharie Saint-Georges

Faculty

1 shared papers, latest 2021

Clifford Cassidy

Psychiatry

1 shared papers, latest 2021

Kyoung-Han Kim

Cellular and Molecular Medicine

1 shared papers, latest 2020

Marc Ruel

Cardiac Surgery

1 shared papers, latest 2022

Robert deKemp

Department of Medicine

1 shared papers, latest 2021

Mary-Ellen Harper

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2020

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: Atherosclerosis Dear Professor Rotstein, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy." (2022), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Rapid discovery of molecular tracers through convergent carbon dioxide fixation chemistry" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]