Wenbin Liang, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Ion Channels Myocardial Infarction Ventricular Arrhythmias Wnt Signaling Heart Failure Electrical Remodeling Ischemic Cardiomyopathy Cardiac Arrhythmias

Latest papers

Sex- and stressor-dependent effects of metformin on cardiac fibrosis in plasminogen activator inhibitor-1 deficiency.
Journal of molecular and cellular cardiology · 2026
Human atrial extracellular vesicles suppress NLRP3 inflammasome activation and profibrotic signaling in a patient-specific iPSC model of postoperative atrial fibrillation.
Theranostics · 2026
Genetic predisposition and mediating pathways in ischemic stroke-induced cardiac arrhythmias: a genome-wide analysis.
Journal of advanced research · 2026

All 34 publications

Latest funding

Role of Wnt5a in Arrhythmogenesis of Heart with Ischemic Cardiomyopathy
CIHR · 2025 · Nominated PI
$1,044,225
Development and validation of a mouse model of cardiac sarcoidosis
CIHR · 2024 · Co-investigator
$300,000
Regulation of T-type Ca2+ channels by Wnt signaling and its role in sinoatrial node dysfunction
CIHR · 2022 · Supervisor
$105,000

All 7 grants and awards

34 publications.

01

Sex- and stressor-dependent effects of metformin on cardiac fibrosis in plasminogen activator inhibitor-1 deficiency.

Pulente SM, Fong-McMaster C, Trzaskalski NA, Ngou E, Oh Y, Kwon S, Stoppenbrink EG, Sebastian M, Haggerty T, Tripathi I, Morrow NM, Lewis M, Morissette A, Lorenzen-Schmidt I, Earl CC, Seymour R, Fortier M, Gupta S, Lewandowska M, Shapiro A, Goergen CJ, Liang W, Kim KH, Mulvihill EE

Journal of molecular and cellular cardiology2026

DOI: 10.1016/j.yjmcc.2026.06.012 PMID: 42402309

02

Human atrial extracellular vesicles suppress NLRP3 inflammasome activation and profibrotic signaling in a patient-specific iPSC model of postoperative atrial fibrillation.

Ahmed N, Ye B, Liang W, Lam BK, Rubens F, Khan S, Courtman D, Stewart DJ, Davis DR

Theranostics2026

DOI: 10.7150/thno.127433 PMID: 42094594

03

Genetic predisposition and mediating pathways in ischemic stroke-induced cardiac arrhythmias: a genome-wide analysis.

Zhao W, Lin HB, Li M, Xu SY, Zhao H, Liang W, Zhang HF

Journal of advanced research2026

DOI: 10.1016/j.jare.2025.12.031 PMID: 41461312

04

Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner.

Kayyem O, Gu R, Xia Y, Wang J, Lu A, Wang H, Davis DR, Liu P, Liang W

Journal of molecular and cellular cardiology plus2025Senior author

DOI: 10.1016/j.jmccpl.2025.100488 PMID: 41098661

05

Mlc2v-Cre induces germline recombination in a sex-biased manner.

Aslani T, Abid R, Jeyaratnam R, Liang W, Kim KH

American journal of physiology. Heart and circulatory physiology2025

DOI: 10.1152/ajpheart.00122.2025 PMID: 40235175

06

Extracellular matrix cues regulate cardiac pacemaker cell induction from ventricular myocytes.

Ngou E, Kim KH, Liang W

American journal of physiology. Heart and circulatory physiology2025Senior author

DOI: 10.1152/ajpheart.00217.2025 PMID: 40209756

07

High Glucose Sensitizes Male and Female Rat Cardiomyocytes to Wnt/β-Catenin Signaling.

Gu R, Wang J, Morin J, Lu A, Liang W

Biomolecules2024Senior author

DOI: 10.3390/biom14121639 PMID: 39766346

08

SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics.

Du Z, Zhou Y, Li Q, Xie Y, Zhu T, Qiao J, Zhang R, Bao Y, Wang L, Xie Y, Quan J, Lin M, Zhang N, Jin Q, Liang W, Wu L, Yin T, Xie Y

JACC. Basic to translational science2024

DOI: 10.1016/j.jacbts.2024.05.011 PMID: 39534638

09

BEaTS-β: an open-source electromechanical bioreactor for simulating human cardiac disease conditions.

Takaya H, Comtois-Bona M, Spasojevic A, Cortes D, Variola F, Liang W, Ruel M, Suuronen EJ, Alarcon EI

Frontiers in bioengineering and biotechnology2023

DOI: 10.3389/fbioe.2023.1253602 PMID: 37781536

10

Inhibition of Wnt/β-catenin signaling upregulates Nav 1.5 channels in Brugada syndrome iPSC-derived cardiomyocytes.

Lu A, Gu R, Chu C, Xia Y, Wang J, Davis DR, Liang W

Physiological reports2023Senior author

DOI: 10.14814/phy2.15696 PMID: 37226398

Role of Wnt5a in Arrhythmogenesis of Heart with Ischemic Cardiomyopathy

Nominated PICIHR2025Project Grant

Principal investigators: Liang, Wenbin

Keywords: Ion Channels; Ischemic Cardiomyopathy; Ventricular Arrhythmias; Wnt Signaling

$1,044,225

Development and validation of a mouse model of cardiac sarcoidosis

Co-investigatorCIHR2024Cat Gr: Develop./validation of new biomedical techniques/technolo.- General Pool

Principal investigators: Davis, Darryl R

Keywords: Cardiac Sarcoidosis

$300,000

Regulation of T-type Ca2+ channels by Wnt signaling and its role in sinoatrial node dysfunction

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Wang, Jerry

Keywords: Arrhythmias; Electrophysiology; Heart Failure; Molecular Biology; Optical Mapping; Single-Cell Patch-Clamp; Wnt Signaling

$105,000

Role of Tbx3 in cardiomyocyte apoptosis after myocardial infarction

Nominated PICIHR2021Project Grant

Principal investigators: Liang, Wenbin

Keywords: Heart Failure; Myocardial Infarction

$757,350

Pre-clinical evaluation of micro-tissue injection and self-assembly in vivo for cardiac repairs.

Co-investigatorCIHR2018Project Grant

Principal investigators: Zhang, Boyang

Keywords: Cardiac Repair; Cardiomyocytes; Magnetic Materials; Scaffolds; Surgery; Tissue Engineering

$386,324

Novel mechanisms of ventricular tachyarrhythmias: Roles of Tbx3 and GABA type A receptors

Nominated PICIHR2018Early Career Investigator Awards- Circulatory and Respiratory Health- Researcher

Principal investigators: Liang, Wenbin

Keywords: Cardiac Arrhythmias; Electrical Remodeling; Ion Channels; Myocardial Infarction

$345,000

Role of Wnt Signaling in Cardiac Arrhythmogenesis

Nominated PICIHR2016Project Grant

Principal investigators: Liang, Wenbin

Keywords: Cardiomyocytes; Electrical Remodeling; Heart Failure; Ion Channels; Myocardial Infarction; Optical Mapping; Patch-Clamp; Signal Transduction; Ventricular Arrhythmias; Wnt Signaling

$577,200

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry, Microbiology and Immunology
Cellular and Molecular Medicine
Cardiac Surgery
Department of Medicine
Chemical Engineering
Biochemistry, Microbiology & Immunology
Surgery
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Marc Ruel

Cardiac Surgery

6 shared papers, latest 2023

Kyoung-Han Kim

Cellular and Molecular Medicine

4 shared papers, latest 2026

Benjamin Rotstein

Biochemistry, Microbiology and Immunology

2 shared papers, latest 2022

David Courtman

Faculty

2 shared papers, latest 2026

Peter Liu

Department of Medicine

2 shared papers, latest 2025

Mary-Ellen Harper

Biochemistry, Microbiology and Immunology

2 shared papers, latest 2020

Erin Mulvihill

Biochemistry, Microbiology & Immunology

1 shared papers, latest 2019

May Griffith

Faculty

1 shared papers, latest 2017

Mona Nemer

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2021

Michel Godin

Faculty

1 shared papers, latest 2020

Fraser Rubens

Surgery

1 shared papers, latest 2026

Boyang Zhang

Chemical Engineering

1 shared papers, latest 2020

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Ion Channels Dear Professor Liang, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Sex- and stressor-dependent effects of metformin on cardiac fibrosis in plasminogen activator inhibitor-1 deficiency." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Role of Wnt5a in Arrhythmogenesis of Heart with Ischemic Cardiomyopathy" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Wenbin Liang

Research

Latest papers

Latest funding

Sex- and stressor-dependent effects of metformin on cardiac fibrosis in plasminogen activator inhibitor-1 deficiency.

Human atrial extracellular vesicles suppress NLRP3 inflammasome activation and profibrotic signaling in a patient-specific iPSC model of postoperative atrial fibrillation.

Genetic predisposition and mediating pathways in ischemic stroke-induced cardiac arrhythmias: a genome-wide analysis.

Wnt/&#x3b2;-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner.

Mlc2v-Cre induces germline recombination in a sex-biased manner.

Extracellular matrix cues regulate cardiac pacemaker cell induction from ventricular myocytes.

High Glucose Sensitizes Male and Female Rat Cardiomyocytes to Wnt/&#x3b2;-Catenin Signaling.

SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction&#xa0;by Promoting Mitochondrial&#xa0;Bioenergetics.

BEaTS-&#x3b2;: an open-source electromechanical bioreactor for simulating human cardiac disease conditions.

Inhibition of Wnt/&#x3b2;-catenin signaling upregulates Nav 1.5 channels in Brugada syndrome iPSC-derived cardiomyocytes.

Role of Wnt5a in Arrhythmogenesis of Heart with Ischemic Cardiomyopathy

Development and validation of a mouse model of cardiac sarcoidosis

Regulation of T-type Ca2+ channels by Wnt signaling and its role in sinoatrial node dysfunction

Role of Tbx3 in cardiomyocyte apoptosis after myocardial infarction

Pre-clinical evaluation of micro-tissue injection and self-assembly in vivo for cardiac repairs.

Novel mechanisms of ventricular tachyarrhythmias: Roles of Tbx3 and GABA type A receptors

Role of Wnt Signaling in Cardiac Arrhythmogenesis

Frequent collaborators

Marc Ruel

Kyoung-Han Kim

Benjamin Rotstein

David Courtman

Peter Liu

Mary-Ellen Harper

Erin Mulvihill

May Griffith

Mona Nemer

Michel Godin

Fraser Rubens

Boyang Zhang

Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner.

High Glucose Sensitizes Male and Female Rat Cardiomyocytes to Wnt/β-Catenin Signaling.

SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics.

BEaTS-β: an open-source electromechanical bioreactor for simulating human cardiac disease conditions.

Inhibition of Wnt/β-catenin signaling upregulates Nav 1.5 channels in Brugada syndrome iPSC-derived cardiomyocytes.