Edward Clark, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Acute Kidney Injury Critical Illness Dialysis Hemodynamic Instability Related To Renal Replacement Therapy Intradialytic Hypotension Intravenous Albumin Multicentre Randomized Controlled Trial Renal Replacement Therapy

Latest papers

Anticoagulation for Patients with Atrial Fibrillation Receiving Dialysis
Journal of the American Society of Nephrology · 2025
Perioperative management of apixaban in patients with advanced CKD undergoing a planned invasive procedure
Blood advances · 2024
Adverse Gastrointestinal Events With Sodium Polystyrene Sulfonate Use in Patients on Maintenance Hemodialysis: An International Cohort Study.
Canadian journal of kidney health and disease · 2023

All 25 publications

Latest funding

Comparing hypOtherMic teMperaturEs duriNg hemiarCh surgEry: COMMENCE Trial
CIHR · 2025 · Co-investigator
$910,350
ALbumin To Enhance Recovery after severe Acute Kidney Injury (ALTER-AKI): a multicentre randomized controlled trial.
CIHR · 2023 · Nominated PI
$956,249
Development of novel techniques for non-invasive continuous cardiovascular monitoring for early detection and treatment of intradialytic hypotension
SSHRC · 2022 · Principal investigator
$125,000

All 4 grants and awards

25 publications.

01

Anticoagulation for Patients with Atrial Fibrillation Receiving Dialysis

Harel Z, Smyth B, Badve SV, Blum D, Beaubien-Souligny W, Silver SA, Clark E, Suri R, Mavrakanas TA, Sasal J

Journal of the American Society of Nephrology202522 citations

DOI: 10.1681/asn.0000000000000495

02

Perioperative management of apixaban in patients with advanced CKD undergoing a planned invasive procedure

Hrubesz G, Dwyer K, McIsaac DI, Sood MM, Clark E, Douketis J, Carrier M, Shaw JR

Blood advances20246 citations

DOI: 10.1182/bloodadvances.2023012380

03

Adverse Gastrointestinal Events With Sodium Polystyrene Sulfonate Use in Patients on Maintenance Hemodialysis: An International Cohort Study.

Farfan Ruiz AC, Malick R, Rhodes E, Clark E, Hundemer G, Karaboyas A, Robinson B, Pecoits R, Sood MM

Canadian journal of kidney health and disease2023

DOI: 10.1177/20543581231172405 PMID: 37359984

04

Proteinuria and venous thromboembolism in pregnancy: a population-based cohort study

Akbari A, Kunkel E, Bota SE, Harel Z, Le Gal G, Cox C, Hundemer GL, Canney M, Clark E, Massicotte-Azarniouch D

CKJ: Clinical Kidney Journal20217 citationsOpen Access

DOI: 10.1093/ckj/sfaa278 PMID: W3118642920

05

Letter to the editor regarding "Accelerated versus standard initiation of renal replacement therapy for critically ill patients with acute kidney injury: a systematic review and meta-analysis of RCT studies".

Magner K, Clark E, Hiremath S

Critical care (London, England)2021

DOI: 10.1186/s13054-021-03528-2 PMID: 33750433

06

A Systematic Review of the Effect of N-Acetylcysteine on Serum Creatinine and Cystatin C Measurements.

Huang JW, Lahey B, Clarkin OJ, Kong J, Clark E, Kanji S, McCudden C, Akbari A, J W Chow B, Shabana W, Hiremath S

Kidney international reports2021

DOI: 10.1016/j.ekir.2020.11.018 PMID: 33615065

07

High Anion Gap Metabolic Acidosis on Continuous Renal Replacement Therapy.

Sriperumbuduri S, Clark E, Biyani M, Ruzicka M

Kidney international reports2020

DOI: 10.1016/j.ekir.2020.07.014 PMID: 33102978

08

Does Iodinated Contrast Affect Residual Renal Function in Dialysis Patients? A Systematic Review and Meta-Analysis.

Oloko A, Talreja H, Davis A, McCormick B, Clark E, Akbari A, Kong J, Hiremath S

Nephron2020

DOI: 10.1159/000505576 PMID: 32155642

09

New Insights Into Mechanisms of Acute Kidney Injury in Heart Disease.

Sriperumbuduri S, Clark E, Hiremath S

The Canadian journal of cardiology2019

DOI: 10.1016/j.cjca.2019.06.032 PMID: 31472814

10

Outpatient kidney recovery after acute kidney injury requiring dialysis: a systematic review protocol.

Wang C, Hiremath S, Sikora L, Sood MM, Kong J, Clark E

Systematic reviews2019Senior author

DOI: 10.1186/s13643-019-1134-1 PMID: 31439026

Comparing hypOtherMic teMperaturEs duriNg hemiarCh surgEry: COMMENCE Trial

Co-investigatorCIHR2025Project Grant

Principal investigators: Boodhwani, Munir

Keywords: Acute Kidney Injury; Aortic Arch; Aortic Surgery; Hypothermia; Randomized Clinical Trial; Stroke

$910,350

ALbumin To Enhance Recovery after severe Acute Kidney Injury (ALTER-AKI): a multicentre randomized controlled trial.

Nominated PICIHR2023Project Grant

Principal investigators: Clark, Edward G; Bagshaw, Sean M; Callum, Jeannie L; Wald, Ron

Keywords: Acute Kidney Injury; Critical Illness; Dialysis; Hemodynamic Instability Related To Renal Replacement Therapy; Intradialytic Hypotension; Intravenous Albumin; Multicentre Randomized Controlled Trial; Renal Replacement Therapy; Ultrafiltration

$956,249

Development of novel techniques for non-invasive continuous cardiovascular monitoring for early detection and treatment of intradialytic hypotension

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Clark, Edward

Keywords: hemodialysis intradialytic hypotension continuous cardiovascular monitoring remote vital signs monitoring optical sensors intrared sensors sensors networks signals processing

$125,000

Development of novel techniques for non-invasive continuous cardiovascular monitoring for early detection and treatment of intradialytic hypotension

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Clark, Edward

Keywords: hemodialysis; intradialytic hypotension; continuous cardiovascular monitoring; remote vital signs monitoring; optical sensors; intrared sensors; sensors networks; signals processing

$125,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Amit Garg and Ron Wald: 69 shared papers
Ron Wald and Ziv Harel: 63 shared papers
Michael Walsh and Amit Garg: 53 shared papers
Amit Garg and Ziv Harel: 37 shared papers
Swapnil Hiremath and Ayub Akbari: 31 shared papers
John Eikelboom and James Demetrios Douketis: 28 shared papers
Amit Garg and John Eikelboom: 22 shared papers
Karen Burns and Francois Lamontagne: 22 shared papers
Michael Walsh and Ron Wald: 21 shared papers
Amit Garg and Louise Moist: 17 shared papers
Ron Wald and Swapnil Hiremath: 16 shared papers
Amit Garg and Swapnil Hiremath: 13 shared papers
Swapnil Hiremath and Edward Clark: 13 shared papers
Christopher McCudden and Ayub Akbari: 13 shared papers
Swapnil Hiremath and Cedric Edwards: 12 shared papers
Karen Burns and Ron Wald: 11 shared papers
Charmaine Lok and Louise Moist: 11 shared papers
Michael Walsh and John Eikelboom: 10 shared papers
Francois Lamontagne and Anand Kumar: 10 shared papers
James Demetrios Douketis and Grégoire Le Gal: 9 shared papers
Swapnil Hiremath and Louise Moist: 9 shared papers
Swapnil Hiremath and Brendan McCormick: 8 shared papers
Amit Garg and Karen Burns: 7 shared papers
Charmaine Lok and Edward Clark: 7 shared papers
Swapnil Hiremath and Christopher McCudden: 7 shared papers
Amit Garg and Charmaine Lok: 6 shared papers
Swapnil Hiremath and Jennifer Macrae: 6 shared papers
Edward Clark and Louise Moist: 6 shared papers
Brendan McCormick and Cedric Edwards: 6 shared papers
Ron Wald and Ayub Akbari: 5 shared papers
Ayub Akbari and Brendan McCormick: 5 shared papers
Ron Wald and Stephen Lapinsky: 4 shared papers
Jennifer Macrae and Louise Moist: 4 shared papers
Michael Walsh and James Demetrios Douketis: 3 shared papers
Michael Walsh and Claudio Rigatto: 3 shared papers
Michael Walsh and Ziv Harel: 3 shared papers
Michael Walsh and Edward Clark: 3 shared papers
Amit Garg and Claudio Rigatto: 3 shared papers
Amit Garg and Jennifer Macrae: 3 shared papers
Karen Burns and David Klein: 3 shared papers
Karen Burns and Stephen Lapinsky: 3 shared papers
Francois Lamontagne and Ron Wald: 3 shared papers
Ron Wald and David Klein: 3 shared papers
Ayub Akbari and Edward Clark: 3 shared papers
Ayub Akbari and Cedric Edwards: 3 shared papers
Michael Walsh and Ron Wald: 2 shared papers
Amit Garg and David Klein: 2 shared papers
Karen Burns and Edward Clark: 2 shared papers
Claudio Rigatto and Ron Wald: 2 shared papers
Claudio Rigatto and Anand Kumar: 2 shared papers
Francois Lamontagne and Stephen Lapinsky: 2 shared papers
Ron Wald and Fabrice Mac-Way: 2 shared papers
Ron Wald and Edward Clark: 2 shared papers
Anand Kumar and Stephen Lapinsky: 2 shared papers
Ziv Harel and Edward Clark: 2 shared papers
Jennifer Macrae and Edward Clark: 2 shared papers
Edward Clark and Ron Wald: 2 shared papers
Edward Clark and Stephen Lapinsky: 2 shared papers
Michael Walsh and Fabrice Mac-Way: 1 shared paper
Amit Garg and Edward Clark: 1 shared paper
John Eikelboom and Fabrice Mac-Way: 1 shared paper
John Eikelboom and Edward Clark: 1 shared paper
James Demetrios Douketis and Edward Clark: 1 shared paper
Conor Cox and Ziv Harel: 1 shared paper
Conor Cox and Grégoire Le Gal: 1 shared paper
Conor Cox and Ayub Akbari: 1 shared paper
Conor Cox and Edward Clark: 1 shared paper
Karen Burns and Ron Wald: 1 shared paper
Claudio Rigatto and Edward Clark: 1 shared paper
Francois Lamontagne and Edward Clark: 1 shared paper
Fabrice Mac-Way and Edward Clark: 1 shared paper
Anand Kumar and Edward Clark: 1 shared paper
Christopher McCudden and Edward Clark: 1 shared paper
Ziv Harel and Grégoire Le Gal: 1 shared paper
Grégoire Le Gal and Edward Clark: 1 shared paper
David Klein and Edward Clark: 1 shared paper
Edward Clark and Brendan McCormick: 1 shared paper
Edward Clark and Cedric Edwards: 1 shared paper

Department of Medicine
Medicine
Nephrology
Health Research Methods, Evidence, and Impact
Medicine/Nephrology
General Internal Medicine
Pathology and Laboratory Medicine
Other

1 shared papers, latest 2025

Anand Kumar

General Internal Medicine

1 shared papers, latest 2016

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Acute Kidney Injury Dear Professor Clark, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Anticoagulation for Patients with Atrial Fibrillation Receiving Dialysis" (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "ALbumin To Enhance Recovery after severe Acute Kidney Injury (ALTER-AKI): a multicentre randomized controlled trial." (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]