David Klein, University of Toronto

Research

Biomarker Peripheral Arterial Disease Screening

Latest papers

Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial.
The Lancet. Respiratory medicine · 2026
Preparing for resilience — Si Vis Pacem, Para Bellum
Canadian Journal of Public Health · 2026
A comparative analysis of supply chain factors impacting COVID-19 vaccine security in high-income countries (HICs) and low-income and middle-income countries (LMICs).
BMJ global health · 2024 · senior author

All 10 publications

Latest funding

Artery Alert - Revolutionizing the Diagnosis of Peripheral Arterial Disease
CIHR · 2021 · Principal investigator
$428,400
STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI)
CIHR · 2014 · Co-investigator
$100,000
STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI)
CIHR · 2010 · Co-investigator
$227,720

All 3 grants and awards

10 publications.

01

Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial.

Neyra JA, Legrand M, Tidswell MA, Al-Khafaji A, Galphin C, Rains R, Davison D, Tolwani A, Chen JT, Bender WS, Busse LW, Meena NK, DellaVolpe J, Williams GW, Kashani KB, Gunnerson KJ, McMahon BA, Eaton J, Khan S, Kohli-Seth R, Jagpal S, Klein D, Kamaluddin E, Foster DM, Walker PM, Tomlinson G, Kellum JA

The Lancet. Respiratory medicine2026

DOI: 10.1016/s2213-2600(26)00047-0 PMID: 41887242

02

Preparing for resilience — Si Vis Pacem, Para Bellum

Haldane V, Beckett A, Engels P, Forestier C, Gomez D, Klein D, Pedlar D, Puri M, Redpath D, Robb A

Canadian Journal of Public Health20261 citations

DOI: 10.17269/s41997-025-01106-5

03

A comparative analysis of supply chain factors impacting COVID-19 vaccine security in high-income countries (HICs) and low-income and middle-income countries (LMICs).

Puri M, Veillard JH, Brown A, Klein D

BMJ global health2024Senior author

DOI: 10.1136/bmjgh-2024-015136 PMID: 39521454

04

The determinants of effective inter-organization information sharing in the health capital planning process.

Kashef Al-Ghetaa R, Daniel I, Shaw J, Klein D, Brown A

Healthcare management forum2022

DOI: 10.1177/08404704221087408 PMID: 35507410

05

Endotoxemia Following Multiple Trauma

Charbonney E, Tsang JY, Li Y, Klein D, Duque P, Romaschin A, Marshall JC

Critical Care Medicine201641 citations

DOI: 10.1097/ccm.0000000000001404

06

Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury

Wald R, Adhikari NKJ, Smith OM, Weir MA, Pope K, Cohen A, Thorpe K, McIntyre L, Lamontagne F, Soth M

Kidney International2015235 citations

DOI: 10.1038/ki.2015.184

07

Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study

Kitchlu A, Adhikari N, Burns KEA, Friedrich JO, Garg AX, Klein D, Richardson RM, Wald R

BMC Nephrology201565 citations

DOI: 10.1186/s12882-015-0123-4

08

Epidemiology of acute kidney injury in Canadian critical care units: a prospective cohort study

Odutayo A, Adhikari NKJ, Barton J, Burns KEA, Friedrich JO, Klein D, Lapinsky S, Litwin S, Meret A, Moineddin R

Canadian Journal of Anaesthesia201230 citations

DOI: 10.1007/s12630-012-9761-1

09

The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury.

Topolovec-Vranic J, Pollmann-Mudryj MA, Ouchterlony D, Klein D, Spence J, Romaschin A, Rhind S, Tien HC, Baker AJ

The Journal of trauma2011

DOI: 10.1097/ta.0b013e318232fa70 PMID: 22072007

10

Intensive care of the patient following open abdominal aortic surgery.

Papia G, Klein D, Lindsay TF

Current opinion in critical care2006

DOI: 10.1097/01.ccx.0000235212.86859.54 PMID: 16810045

Artery Alert - Revolutionizing the Diagnosis of Peripheral Arterial Disease

Principal investigatorCIHR2021Project Grant

Principal investigators: Qadura, Mohammad; Klein, David J; Rotstein, Ori D

Keywords: Biomarker; Peripheral Arterial Disease; Screening

$428,400

STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI)

Co-investigatorCIHR2014Operating Grant

Principal investigators: Wald, Ron; Bagshaw, Sean M

Keywords: Acute Kidney Injury; Hemodialysis; Intensive Care Unit; Randomized Controlled Trial; Timing

$100,000

STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI)

Co-investigatorCIHR2010Operating Grant

Principal investigators: Wald, Ron; Bagshaw, Sean M

Keywords: Acute Kidney Injury; Hemodialysis; Intensive Care Unit; Randomized Controlled Trial; Timing

$227,720

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Health Research Methods, Evidence, and Impact
Nephrology
Department of Medicine
Medicine/Nephrology
Surgery
Médecine interne
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Ron Wald

Nephrology

3 shared papers, latest 2015

Karen Burns

Health Research Methods, Evidence, and Impact

3 shared papers, latest 2015

Adalsteinn Brown

Medicine

3 shared papers, latest 2026

Stephen Lapinsky

Department of Medicine

2 shared papers, latest 2015

Amit Garg

Health Research Methods, Evidence, and Impact

2 shared papers, latest 2015

Edward Clark

Department of Medicine

1 shared papers, latest 2015

Ayodele Odutayo

Medicine/Nephrology

1 shared papers, latest 2012

Rahim Moineddin

Department of Family and Community Medicine

1 shared papers, latest 2012

Francois Lamontagne

Médecine interne

1 shared papers, latest 2015

Lauralyn McIntyre

Clinical Epidemiology

1 shared papers, latest 2015

Kevin Thorpe

Surgery

1 shared papers, latest 2015

Neill Adhikari

Anesthesiology and Pain Management

1 shared papers, latest 2015

Swapnil Hiremath

Nephrology

1 shared papers, latest 2015

James Shaw

Lunenfeld-Tanenbaum Research Institute

1 shared papers, latest 2022

George Tomlinson

Biostatistics Division

1 shared papers, latest 2026

Jennifer Tsang

Medicine

1 shared papers, latest 2016

Margaret Herridge

Critical Care Medicine

1 shared papers, latest 2015

Paul Engels

Surgery

1 shared papers, latest 2026

Mark Soth

Medicine

1 shared papers, latest 2015

Michelle Hladunewich

Medicine/Nephrology

1 shared papers, latest 2012

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: Biomarker Dear Professor Klein, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Artery Alert - Revolutionizing the Diagnosis of Peripheral Arterial Disease" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]