Kristin Baetz, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Biochemistry Cancer Genetics Kat5/Nua4 Kdac And Kats Lysine Acetylation Proteomics Stress Granules

Latest papers

Uncovering the Role of the Yeast Lysine Acetyltransferase NuA4 in the Regulation of Nuclear Shape and Lipid Metabolism.
Molecular and cellular biology · 2024 · senior author
Pab1 acetylation at K131 decreases stress granule formation in Saccharomyces cerevisiae.
The Journal of biological chemistry · 2023 · senior author
Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization.
Genetics · 2022 · senior author

All 26 publications

Latest funding

Can engineering protein subcellular localization protect yeast cells from toxic fermentation inhibitors?
NSERC · 2019 · Principal investigator
$120,000
Can engineering protein subcellular localization protect yeast cells from toxic fermentation inhibitors?
NSERC · 2019 · Principal investigator
$492,000
Training Program in Synthetic Biology Applications (SynBioApps)
NSERC · 2018 · Co-investigator
$1,650,000

All 15 grants and awards

26 publications.

01

Uncovering the Role of the Yeast Lysine Acetyltransferase NuA4 in the Regulation of Nuclear Shape and Lipid Metabolism.

Laframboise SJ, Deneault LF, Denoncourt A, Downey M, Baetz K

Molecular and cellular biology2024Senior author

DOI: 10.1080/10985549.2024.2366206 PMID: 38961766

02

Pab1 acetylation at K131 decreases stress granule formation in Saccharomyces cerevisiae.

Sivananthan S, Gosse JT, Huard S, Baetz K

The Journal of biological chemistry2023Senior author

DOI: 10.1016/j.jbc.2022.102834 PMID: 36572187

03

Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization.

Pham T, Walden E, Huard S, Pezacki J, Fullerton MD, Baetz K

Genetics2022Senior author

DOI: 10.1093/genetics/iyac086 PMID: 35608294

04

Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.

Robichaud S, Fairman G, Vijithakumar V, Mak E, Cook DP, Pelletier AR, Huard S, Vanderhyden BC, Figeys D, Lavallée-Adam M, Baetz K, Ouimet M

Autophagy2021

DOI: 10.1080/15548627.2021.1886839 PMID: 33590792

05

Global analysis of Saccharomyces cerevisiae growth in mucin.

Mercurio K, Singh D, Walden E, Baetz K

G3 (Bethesda, Md.)2021Senior author

DOI: 10.1093/g3journal/jkab294 PMID: 34849793

06

A yeast chemogenomic screen identifies pathways that modulate adipic acid toxicity.

Fletcher E, Mercurio K, Walden EA, Baetz K

iScience2021Senior author

DOI: 10.1016/j.isci.2021.102327 PMID: 33889823

07

Phenomic screen identifies a role for the yeast lysine acetyltransferase NuA4 in the control of Bcy1 subcellular localization, glycogen biosynthesis, and mitochondrial morphology.

Walden EA, Fong RY, Pham TT, Knill H, Laframboise SJ, Huard S, Harper ME, Baetz K

PLoS genetics2020Senior author

DOI: 10.1371/journal.pgen.1009220 PMID: 33253187

08

Multi-Faceted Systems Biology Approaches Present a Cellular Landscape of Phenolic Compound Inhibition in Saccharomyces cerevisiae.

Fletcher E, Baetz K

Frontiers in bioengineering and biotechnology2020Senior author

DOI: 10.3389/fbioe.2020.539902 PMID: 33154962

09

Yeast chemogenomic screen identifies distinct metabolic pathways required to tolerate exposure to phenolic fermentation inhibitors ferulic acid, 4-hydroxybenzoic acid and coniferyl aldehyde.

Fletcher E, Gao K, Mercurio K, Ali M, Baetz K

Metabolic engineering2019Senior author

DOI: 10.1016/j.ymben.2018.11.010 PMID: 30471359

10

A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems.

Huang J, Mousley CJ, Dacquay L, Maitra N, Drin G, He C, Ridgway ND, Tripathi A, Kennedy M, Kennedy BK, Liu W, Baetz K, Polymenis M, Bankaitis VA

Developmental cell2018

DOI: 10.1016/j.devcel.2017.12.026 PMID: 29396115

Can engineering protein subcellular localization protect yeast cells from toxic fermentation inhibitors?

Principal investigatorNSERC2019Discovery Grants Program - Accelerator Supplements

Principal investigators: Baetz, Kristin

$120,000

Can engineering protein subcellular localization protect yeast cells from toxic fermentation inhibitors?

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Baetz, Kristin

$492,000

Training Program in Synthetic Biology Applications (SynBioApps)

Co-investigatorNSERC2018Collaborative Research and Training Experience

Principal investigators: Whiteway, Malcolm

$1,650,000

Operations and Maintenance Support: Proteomic Resource Center

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Figeys, Daniel

$163,458

NSERC CREATE in Technologies for Microbiome Science and Engineering (TECHNOMISE)

Co-investigatorNSERC2017Collaborative Research and Training Experience

Principal investigators: Figeys, Daniel

$1,650,000

Elucidating the role of lysine acetylation in stress granule dynamics

Nominated PICIHR2015Operating Grant

Principal investigators: Baetz, Kristin K

Keywords: Biochemistry; Cancer; Genetics; Kat5/Nua4; Kdac And Kats; Lysine Acetylation; Proteomics; Stress Granules; Stress Response; Yeast Genetics And Molecular Biology

$608,103

Aberrant phospholipid and sphingolipid metabolism is a primary and targetable pathology in Alzheimer Disease

Co-investigatorCIHR2013Operating Grant

Principal investigators: Bennett, Steffany A; Figeys, Daniel

Keywords: Alzheimer Disease; Biomarkers; Gender; Lipidomics; Mass Spectrometry; Mouse Models Of Alzheimer Disease; Phospholipids; Proteomics; Super Resolution Microscopy; Synaptotoxicity

$778,945

Optimizing Yeast For Xylose Fermentation Through Systems Biology

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Baetz, Kristin

$280,000

Systematic analysis of NuA4 auto-acetylation

SupervisorCIHR2010Master's Award: Canada Graduate Scholarships

Principal investigators: Pourhanifeh-Lemeri, Roghayeh

Keywords: Auto-Acetylation; Cancer; Chromosome (Genome) Instability; Eaf1; Epl1; Nua4 Lysine Acetyltransferase; Post-Translational Modification (Ptm); Saccharomyces Cerevisiae; Systematic Genetic Analysis; Tip60 Complex

$17,500

CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Nominated PICIHR2010Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Baetz, Kristin K

Keywords: Crc

$500,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry, Microbiology and Immunology
Cellular and Molecular Medicine
Biochemistry, Microbiology & Immunology
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Daniel Figeys

Biochemistry, Microbiology and Immunology

7 shared papers, latest 2021

Mary-Ellen Harper

Biochemistry, Microbiology and Immunology

2 shared papers, latest 2020

Michael Downey

Cellular and Molecular Medicine

1 shared papers, latest 2024

Mireille Ouimet

Biochemistry, Microbiology & Immunology

1 shared papers, latest 2021

Nancy Maltez

Faculty

1 shared papers, latest 2010

Alain Stintzi

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2017

Mads Kaern

Cellular and Molecular Medicine

1 shared papers, latest 2017

John Pezacki

Faculty

1 shared papers, latest 2022

Corey Nislow

Faculty

1 shared papers, latest 2016

Write to this professor

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Applying for

Paper to mentionMention their NSERC grant from 2019

Subject: Prospective PhD student: Biochemistry Dear Professor Baetz, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Uncovering the Role of the Yeast Lysine Acetyltransferase NuA4 in the Regulation of Nuclear Shape and Lipid Metabolism." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Can engineering protein subcellular localization protect yeast cells from toxic fermentation inhibitors?" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]