Mireille Ouimet, University of Ottawa

Research

Atherosclerosis Cholesterol Efflux Crc Autophagy Hdl Inflammation Surgery Aging

Latest papers

A Rosella-PLIN2 knock-in mouse reveals lipophagy and immunometabolic interplay in atherosclerosis.
Autophagy · 2026 · senior author
Brain-specific ORP6 deficiency in mice disrupts systemic lipid metabolism and impairs hippocampal-dependent learning and memory.
Neuroscience letters · 2026 · senior author
Loss of Rab8a-Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia-Reoxygenation Injury.
MedComm · 2026

All 35 publications

Latest funding

Role of HDL in Postoperative Atherosclerosis
CIHR · 2025 · Nominated PI
$879,750
2025 CSMB-PRinCE Conference - 68th Annual Conference for Canadian Society for Molecular Biosciences (CSMB) and 4th Biennial Proteostasis Researchers in Canada, Eh (PRinCE) Conference
CIHR · 2024 · Co-investigator
$15,000
Role of Postoperative Inflammation in Reverse Cholesterol Transport and Atherogenesis
CIHR · 2022 · Supervisor
$105,000

All 12 grants and awards

35 publications.

01

A Rosella-PLIN2 knock-in mouse reveals lipophagy and immunometabolic interplay in atherosclerosis.

Laval T, Joyce N, Boucher DM, Labrana H, Rochon V, Emerton C, Dharia M, Robichaud S, Lorant V, Nguyen MA, Geoffrion M, Rayner KJ, Gibbings D, Nutter LMJ, Russell RC, Ouimet M

Autophagy2026Senior author

DOI: 10.1080/15548627.2026.2674711 PMID: 42163465

02

Brain-specific ORP6 deficiency in mice disrupts systemic lipid metabolism and impairs hippocampal-dependent learning and memory.

Kasongo AA, Bhunu B, Boucher DM, Vijithakumar V, Aly SH, Emerton C, Rousseaux MWC, Lagace DC, Ouimet M

Neuroscience letters2026Senior author

DOI: 10.1016/j.neulet.2026.138682 PMID: 42435836

03

Loss of Rab8a-Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia-Reoxygenation Injury.

Tang J, Joyce N, Laval T, Tam E, Sung HK, Ouimet M, Sweeney G

MedComm2026

DOI: 10.1002/mco2.70845 PMID: 42568782

04

Early ApoA-I Treatment Prevents Postsurgical Atherosclerotic Plaque Destabilization.

Boucher DM, Lorant V, Barney RP, Bhunu B, Gordon SM, Ouimet M

Circulation research2026Senior author

DOI: 10.1161/circresaha.125.328179 PMID: 42063390

05

Hematopoietic expression of cIAP2 drives inflammation and heart failure after myocardial infarction.

Smyth D, Zhang L, Al-Khalaf M, Robichaud S, Seymour R, Geoffrion M, Jung R, Parlow S, Du F, McNeill B, Du Q, Beauregard C, Zhao X, Ouimet M, Beug ST, LaCasse EC, Rayner KJ, Mak TW, Hibbert B, Korneluk RG, Liu PP

Nature cardiovascular research2026

DOI: 10.1038/s44161-026-00782-x PMID: 41820671

06

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production.

Kasongo AA, Vijithakumar V, Abd-Elrahman KS, Prabhune R, Gharibeh L, Nadeau R, Robillard I, Spring S, Robichaud S, Asif S, Gibbings D, Moore KJ, Sled JG, Ruiz M, Lavallée-Adam M, Ferguson SSG, Lacoste B, Lagace DC, Ouimet M

Journal of lipid research2025Senior author

DOI: 10.1016/j.jlr.2025.100868 PMID: 40716750

07

Cardioprotective Effects of Adiponectin-Stimulated Autophagy.

Tam E, Ouimet M, Sweeney G

Journal of lipid and atherosclerosis2025

DOI: 10.12997/jla.2025.14.1.40 PMID: 39911962

08

Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression

Boucher DM, Robichaud S, Lorant V, Leon JS, Suliman I, Rasheed A, Susser LI, Emerton C, Geoffrion M, De Jong E

Arteriosclerosis, Thrombosis, and Vascular Biology202530 citationsSenior author

DOI: 10.1161/atvbaha.124.321662

09

Hyperlipidemia-induced hematopoiesis is repressed by MLKL in endothelial cells of the splenic niche.

Rasheed A, Robichaud S, Dennison T, Nguyen MA, Geoffrion M, Reed JN, Wyatt HJ, Marouf Y, Baxi A, Lee R, Kazan H, Civelek M, van Solingen C, Ouimet M, Rayner KJ

Nature cardiovascular research2024

DOI: 10.1038/s44161-024-00470-8 PMID: 39195940

10

Trehalose promotes atherosclerosis regression in female mice.

Robichaud S, Rochon V, Emerton C, Laval T, Ouimet M

Frontiers in cardiovascular medicine2024Senior author

DOI: 10.3389/fcvm.2024.1298014 PMID: 38433753

Role of HDL in Postoperative Atherosclerosis

Nominated PICIHR2025Project Grant

Principal investigators: Ouimet, Mireille I

Keywords: Atherosclerosis; Cholesterol Efflux; Hdl; Inflammation; Surgery

$879,750

2025 CSMB-PRinCE Conference - 68th Annual Conference for Canadian Society for Molecular Biosciences (CSMB) and 4th Biennial Proteostasis Researchers in Canada, Eh (PRinCE) Conference

Co-investigatorCIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Lee, Jyh-Yeuan

Keywords: Cell Stress Responses; Human Genetics; Liquid-Liquid Phase Seperation; Metabolic And Cardiovascular Diseases; Molecular Biosciences; Neurodevelopment And Neurodegeration; Post-Translational Modificaton; Protein Homeostasis; Protein Misfolding And Aggregation; Protein Trafficking And Degradation

$15,000

Role of Postoperative Inflammation in Reverse Cholesterol Transport and Atherogenesis

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Boucher, Dominique M

Keywords: Atherosclerosis; Inflammation; Lipid Metabolism; Lipoproteins; Macrophages; Reverse Cholesterol Transport; Surgery

$105,000

Canada Research Chair - Tier 2

Nominated PICIHR2021Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Ouimet, Mireille I

Keywords: Crc

$500,000

Uncovering the role of lipophagy during atherosclerosis regression

SupervisorCIHR2020Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Robichaud, Sabrina

Keywords: Atherosclerosis

$105,000

Age-associated macrophage dysfunction in atherosclerosis regression

Nominated PICIHR2020Project Grant

Principal investigators: Ouimet, Mireille I

Keywords: Aging; Atherosclerosis; Autophagy; Cholesterol; Macrophages; Mitochondria

$787,950

ROLE OF ORP6 IN INTRACELLULAR CHOLESTEROL TRAFFICKING

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Ouimet, Mireille

$185,000

ROLE OF ORP6 IN INTRACELLULAR CHOLESTEROL TRAFFICKING

Principal investigatorNSERC2020Discovery Launch Supplement

Principal investigators: Ouimet, Mireille

$12,500

Identifying the genetic determinants of lipophagy using Saccharomyces cerevisiae

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Fairman, Garrett

Keywords: Atherosclerosis; Budding Yeast; Genetic Screen; Genetics; Lipid Metabolism; Lipophagy; Macrophages; Reverse Cholesterol Transport

$105,000

Identifying the genetic determinants of lipophagy using Saccharomyces cerevisiae

SupervisorCIHR2019Travel Awards - Institute Community Support

Principal investigators: Fairman, Garrett

Keywords: Ics Travel Awards

$781

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry, Microbiology and Immunology
Cellular and Molecular Medicine
Biochemistry, Microbiology & Immunology
Department of Medicine
Biology
Medicine
Nutrition

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Suresh Gadde

Biochemistry, Microbiology and Immunology

2 shared papers, latest 2022

Benjamin Hibbert

Department of Medicine

2 shared papers, latest 2026

Gary Sweeney

Biology

2 shared papers, latest 2026

Derrick Gibbings

Cellular and Molecular Medicine

2 shared papers, latest 2026

Tommy Alain

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2022

Mireille Khacho

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2023

Matthieu Ruiz

Nutrition

1 shared papers, latest 2025

Mary-Ellen Harper

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2015

Dylan Burger

Cellular and Molecular Medicine

1 shared papers, latest 2022

Kristin Baetz

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2021

Dawn Bowdish

Medicine

1 shared papers, latest 2025

Baptiste Lacoste

Cellular and Molecular Medicine

1 shared papers, latest 2025

Daniel Figeys

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2021

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Atherosclerosis Dear Professor Ouimet, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A Rosella-PLIN2 knock-in mouse reveals lipophagy and immunometabolic interplay in atherosclerosis." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Role of HDL in Postoperative Atherosclerosis" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Mireille Ouimet

Research

Latest papers

Latest funding

A Rosella-PLIN2 knock-in mouse reveals lipophagy and immunometabolic interplay in atherosclerosis.

Brain-specific ORP6 deficiency in mice disrupts systemic lipid metabolism and impairs hippocampal-dependent learning and memory.

Loss of Rab8a-Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia-Reoxygenation Injury.

Early ApoA-I Treatment Prevents Postsurgical Atherosclerotic Plaque Destabilization.

Hematopoietic expression of cIAP2 drives inflammation and heart failure after myocardial infarction.

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain A&#x3b2; production.

Cardioprotective Effects of Adiponectin-Stimulated Autophagy.

Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression

Hyperlipidemia-induced hematopoiesis is repressed by MLKL in endothelial cells of the splenic niche.

Trehalose promotes atherosclerosis regression in female mice.

ROLE OF ORP6 IN INTRACELLULAR CHOLESTEROL TRAFFICKING

ROLE OF ORP6 IN INTRACELLULAR CHOLESTEROL TRAFFICKING

Frequent collaborators

Suresh Gadde

Benjamin Hibbert

Gary Sweeney

Derrick Gibbings

Tommy Alain

Mireille Khacho

Matthieu Ruiz

Mary-Ellen Harper

Dylan Burger

Kristin Baetz

Dawn Bowdish

Baptiste Lacoste

Daniel Figeys

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production.