Lynn Megeney, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Caspase Genomics Proteomics Heart Failure Cardiomyocyte Cell Death Cell Differentiation Cardiac Hypertrophy

Latest papers

Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics.
Hypertension (Dallas, Tex. : 1979) · 2022

All 1 publications

Latest funding

Small molecule induction of physiologic hypertrophy to limit/reverse heart failure
CIHR · 2025 · Nominated PI
$864,450
The 3rd international meeting on Non-Lethal Roles of Cell Death Proteins (NLRCDP).
CIHR · 2024 · Nominated PI
$15,000
Caspase 3 stimulation of dystrophic muscle stem cell differentiation
CIHR · 2020 · Nominated PI
$810,900

All 11 grants and awards

1 publications.

01

Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics.

Zelt JGE, Cadete V, Deng Y, Godoy R, Cuillerier A, Rowe K, Abdul-Ghani M, Megeney L, Burelle Y, Giulivi A, Stewart AFR, Provencher S, Breuils-Bonnet S, Bonnet S, deKemp R, Beanlands R, Mielniczuk LM, Stewart DJ

Hypertension (Dallas, Tex. : 1979)2022

DOI: 10.1161/hypertensionaha.122.19300 PMID: 36278405

Small molecule induction of physiologic hypertrophy to limit/reverse heart failure

Nominated PICIHR2025Project Grant

Principal investigators: Megeney, Lynn A

Keywords: Abemaciclib; Cardiomyocyte; Cdk4; Drug Therapy; Genomics; Heart Failure; Physiologic Cardiac Hypertrophy; Proteomics

$864,450

The 3rd international meeting on Non-Lethal Roles of Cell Death Proteins (NLRCDP).

Nominated PICIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Megeney, Lynn A

Keywords: Caspase; Cell Death; Cell Differentiation; Cell Fate; Dnase; Metacaspase; Non-Apoptotic; Omics

$15,000

Caspase 3 stimulation of dystrophic muscle stem cell differentiation

Nominated PICIHR2020Project Grant

Principal investigators: Megeney, Lynn A

Keywords: Caspase 3; Cell Differentiation; Duchenne Muscular Dystrophy; Skeletal Muscle Stem Cells

$810,900

The role of caspase activity in beneficial and adverse cardiac hypertrophy

Nominated PICIHR2019Project Grant

Principal investigators: Megeney, Lynn A

Keywords: Cardiac Hypertrophy; Cardiomyocyte; Caspase; Cell Signaling

$745,875

Defining the Caspase/CAD-Mediated Origin of Alveolar Rhabdomyosarcoma

Nominated PICIHR2017Project Grant

Principal investigators: Megeney, Lynn A

Keywords: Caspase; Caspase Activated Dnase; Dna Damage; Dna Repair; Rhabdomyosarcoma

$707,625

CT1, an inductive cue for beneficial remodelling of the heart

Nominated PICIHR2016Project Grant

Principal investigators: Megeney, Lynn A

Keywords: Cardiac Remodelling; Cardiotrophin; Cytokine; Heart Failure; Physiologic Hypertrophy; Signal Transduction

$707,164

Defining the role of caspase activity in cardiac hypertrophy

Nominated PICIHR2013Operating Grant

Principal investigators: Megeney, Lynn A

Keywords: Cardiac Hypertrophy; Cardiovascular; Caspase; Cell Death

$545,224

Genomic Analysis of Rhabdomyosarcoma Tumor Initiating Cells

Principal investigatorCIHR2013Operating Grant

Principal investigators: Rudnicki, Michael A; Dilworth, Jeffrey J; Megeney, Lynn A; Perkins, Theodore J

Keywords: Alveolar Rhabdomyosarcoma; Bioinformatics; Cancer Stem Cells; Chip-Seq; Epigenetics; Genetics; Genomics; Proteomics

$1,207,800

The role of caspase mediated DNA damage and repair in cell differentiation

Nominated PICIHR2010Operating Grant

Principal investigators: Megeney, Lynn A

Keywords: Differentiation; Dna Damage; Gene Expression

$767,250

The Ottawa Conference on New Directions in Biology & Disease of Skeletal Muscle

Co-investigatorCIHR2010Dissemination Events - PA: Musculoskeletal Hlth, Arthritis, Skin & Oral Health

Principal investigators: Kothary, Rashmi K

Keywords: Genetics; Muscle Biology; Neuromuscular; Skeletal Muscle

$20,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Department of Medicine
Cellular and Molecular Medicine
Médecine
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Robert deKemp

Department of Medicine

1 shared papers, latest 2022

Steeve Provencher

Médecine

1 shared papers, latest 2022

Rob Beanlands

Department of Medicine

1 shared papers, latest 2022

Yan Burelle

Faculty

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Mention their CIHR grant from 2025

Subject: Prospective PhD student: Caspase Dear Professor Megeney, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics." (2022), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Small molecule induction of physiologic hypertrophy to limit/reverse heart failure" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]