Annie Shrestha, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Dentistry and oral health Endodontics

Latest papers

High-Fat Diet Reprograms the Periapical Immune Landscape in a Mouse Model of Apical Periodontitis: A Spatial Transcriptomics Study.
International endodontic journal · 2026 · senior author
MSC-derived small extracellular vesicles promote dental pulp repair by alleviating inflammation in pulpitis via AKT and p38 MAPK pathways.
Stem cells (Dayton, Ohio) · 2026
Mechanical Memory and NF-κB Signaling in Dental Pulp Stem Cell Odontogenic Differentiation.
Journal of endodontics · 2026 · senior author

All 33 publications

33 publications.

01

High-Fat Diet Reprograms the Periapical Immune Landscape in a Mouse Model of Apical Periodontitis: A Spatial Transcriptomics Study.

Ghaffari M, Ali A, Hartadi C, Shrestha A

International endodontic journal2026Senior author

DOI: 10.1111/iej.70237 PMID: 42506892

02

MSC-derived small extracellular vesicles promote dental pulp repair by alleviating inflammation in pulpitis via AKT and p38 MAPK pathways.

Shi J, Jiang Y, Zhang S, Shrestha A, Hu X, Jiang L, Toh WS

Stem cells (Dayton, Ohio)2026

DOI: 10.1093/stmcls/sxag038 PMID: 42423314

03

Mechanical Memory and NF-κB Signaling in Dental Pulp Stem Cell Odontogenic Differentiation.

Ghaffari M, Shrestha A

Journal of endodontics2026Senior author

DOI: 10.1016/j.joen.2026.01.001 PMID: 41520920

04

A Chitosan-based Hydrogel to Modulate Immune Cells and Promote Periodontitis Healing in the High-Fat Diet-induced Periodontitis Rat Model.

Zhu Y, Ali A, Mulinari Dos Santos G, Franciscon JPS, de Molon RS, Goh C, Ervolino E, Theodoro LH, Shrestha A

Acta biomaterialia2025Senior author

DOI: 10.1016/j.actbio.2025.05.034 PMID: 40379118

05

Optimizing Stem Cell Expansion: The Role of Substrate Stiffness in Enhancing Dental Pulp Stem Cell Quiescence and Regeneration.

Ghaffari M, Shrestha A

Journal of endodontics2025Senior author

DOI: 10.1016/j.joen.2025.01.004 PMID: 39814134

06

Metabolic syndrome and its effect on immune cells in apical periodontitis- a narrative review.

Zhu Y, Shrestha A

Clinical oral investigations2025Senior author

DOI: 10.1007/s00784-025-06161-3 PMID: 39825203

07

Web-Based Survey on Regenerative Endodontic Practices among Members of the American Association of Endodontists.

Botero T, Chrepa V, Shrestha A, Gibbs J, Al Hezaimi K, Law A, Sedgley C, Hargreaves KM

Journal of endodontics2024

DOI: 10.1016/j.joen.2024.05.016 PMID: 38906528

08

High-Fat Diet Influences Dendritic Cells and T-Cell Infiltration in Apical Periodontitis in Mice.

Shrestha A, Zhu Y, Ali A

Journal of endodontics2024First author

DOI: 10.1016/j.joen.2024.01.015 PMID: 38280515

09

Innovative biomaterials for the treatment of periodontal disease.

Zhu Y, Tao C, Goh C, Shrestha A

Frontiers in dental medicine2023Senior author

DOI: 10.3389/fdmed.2023.1163562 PMID: 39916927

10

Injectable thermosensitive hydrogel to modulate tolerogenic dendritic cells under hyperglycemic condition.

Zhu Y, Winer D, Goh C, Shrestha A

Biomaterials science2023Senior author

DOI: 10.1039/d2bm01881k PMID: 36723183

Frequent collaborators

Department of Connective Tissue and Regenerative Medicine
Department of Dental Public Health
Medical Microbiology and Immunology
Department of Laboratory Medicine & Pathobiology
Medicine
Rheumatology
Oral Pathology

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Anil Kishen

Department of Connective Tissue and Regenerative Medicine

17 shared papers, latest 2022

Amir Azarpazhooh

Department of Dental Public Health

2 shared papers, latest 2012

Sue Tsai

Medical Microbiology and Immunology

2 shared papers, latest 2022

Marco Magalhaes

Oral Pathology

1 shared papers, latest 2022

Igor Jurisica

Rheumatology

1 shared papers, latest 2021

Daniel Winer

Department of Laboratory Medicine & Pathobiology

1 shared papers, latest 2023

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Paper to mention

Subject: Prospective PhD student: Dentistry and oral health Dear Professor Shrestha, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "High-Fat Diet Reprograms the Periapical Immune Landscape in a Mouse Model of Apical Periodontitis: A Spatial Transcriptomics Study." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Annie Shrestha