Daniel Winer, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Insulin Resistance Obesity Adaptive Immune System Innate Immune System Type 2 Diabetes Aging Inflammation Immunometabolism

Latest papers

Injectable thermosensitive hydrogel to modulate tolerogenic dendritic cells under hyperglycemic condition.
Biomaterials science · 2023
Reversing CXCL10 Deficiency Ameliorates Kidney Disease in Diabetic Mice.
The American journal of pathology · 2018
Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression.
Obesity (Silver Spring, Md.) · 2018

All 13 publications

Latest funding

Investigating New Causes of T cell Aging
CIHR · 2026 · Nominated PI
$1,009,800
Sex-Dependent Intestinal Immune Mechanisms of Obesity Related Insulin Resistance
CIHR · 2024 · Nominated PI
$883,576
Understanding Simulated Microgravity Effects on Immune Cell Biology
NSERC · 2024 · Principal investigator
$55,000

All 17 grants and awards

13 publications.

01

Injectable thermosensitive hydrogel to modulate tolerogenic dendritic cells under hyperglycemic condition.

Zhu Y, Winer D, Goh C, Shrestha A

Biomaterials science2023

DOI: 10.1039/d2bm01881k PMID: 36723183

02

Reversing CXCL10 Deficiency Ameliorates Kidney Disease in Diabetic Mice.

Zhang Y, Thai K, Kepecs DM, Winer D, Gilbert RE

The American journal of pathology2018

DOI: 10.1016/j.ajpath.2018.08.017 PMID: 30273603

03

Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression.

Song Z, Revelo X, Shao W, Tian L, Zeng K, Lei H, Sun HS, Woo M, Winer D, Jin T

Obesity (Silver Spring, Md.)2018

DOI: 10.1002/oby.22110 PMID: 29405636

04

Xanthomatous Hypophysitis Is Associated with Ruptured Rathke's Cleft Cyst.

Duan K, Asa SL, Winer D, Gelareh Z, Gentili F, Mete O

Endocrine pathology2017

DOI: 10.1007/s12022-017-9471-x PMID: 28120170

05

Thyroglossal Duct Cyst Associated with Xanthogranulomatous Inflammation.

Taskin OC, Gucer H, Winer D, Mete O

Head and neck pathology2015

DOI: 10.1007/s12105-015-0628-y PMID: 25896144

06

Images in endocrine pathology: papillary variant of medullary thyroid carcinoma with cystic change.

Hyrcza MD, Winer D, Mete O

Endocrine pathology2015

DOI: 10.1007/s12022-014-9332-9 PMID: 25246133

07

Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomas.

Cassol CA, Winer D, Liu W, Guo M, Ezzat S, Asa SL

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2014

DOI: 10.1038/modpathol.2013.233 PMID: 24390213

08

XB130, a novel adaptor protein, promotes thyroid tumor growth.

Shiozaki A, Lodyga M, Bai XH, Nadesalingam J, Oyaizu T, Winer D, Asa SL, Keshavjee S, Liu M

The American journal of pathology2011

DOI: 10.1016/j.ajpath.2010.11.024 PMID: 21224076

09

Osteopontin (OPN) expression in thyroid carcinoma.

Briese J, Cheng S, Ezzat S, Liu W, Winer D, Wagener C, Bamberger AM, Asa SL

Anticancer research2010

PMID: 20592361

10

Normalization of obesity-associated insulin resistance through immunotherapy

Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J, Dorfman R, Wang Y, Zielenski J, Mastronardi F

Nature Medicine20091,292 citations

DOI: 10.1038/nm.2001

Investigating New Causes of T cell Aging

Nominated PICIHR2026Project Grant

Principal investigators: Winer, Daniel A

Keywords: Aging; Cell-Cell Communication; Healthspan; Inflammaging; Inflammation; Lifespan; Lymphocytes; Mouse Models; Pathology; T And B Cells

$1,009,800

Sex-Dependent Intestinal Immune Mechanisms of Obesity Related Insulin Resistance

Nominated PICIHR2024Project Grant

Principal investigators: Winer, Daniel A

Keywords: Gut Barrier; Immunometabolism; Inflammation; Innate And Adaptive Immunity; Insulin Resistance; Intestine; Mouse Models; Mucosal Immunity; Obesity; Sex-Differences In Biology

$883,576

Understanding Simulated Microgravity Effects on Immune Cell Biology

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Winer, Daniel

Keywords: simulated microgravity; immune cells; mechanoimmunology; danger sensing; cytokines; cell biology; rotating wall vessel; immunometabolism; gravity

$55,000

Mechanisms of B cell mediated inflammation during aging

Nominated PICIHR2022Project Grant

Principal investigators: Winer, Daniel A

Keywords: Aging; Healthspan; Immunosenescence; Inflammaging; Inflammation; Insulin; Lymphocytes; Metabolism; Pathology; T And B Cells

$918,000

The Role of Intramuscular Immune Cell Infiltrations in Tumor and Age Related Muscle Wasting

Nominated PICIHR2019Project Grant

Principal investigators: Winer, Daniel A; Clemente Casares, Javier

Keywords: Activin; Aging; Cachexia; Cancer; Cytokines; Heart; Immunometabolism; Muscle; Myeloid Derived Suppressor Cells; Sarcopenia

$803,250

The Immunological Impact of Direct Acting Antiviral Treatment for Early HCV Infection

Co-investigatorCIHR2018Project Grant

Principal investigators: MacParland, Sonya; Feld, Jordan J

Keywords: Hepatitis C Virus; Liver Immunology; Single Cell Rna Sequencing; Viral Pathogenesis

$604,350

Role of Insulin in T cell Function

SupervisorCIHR2016CIHR Fellowship

Principal investigators: Tsai, Sue Y

Keywords: Insulin Resistance; Obesity; T Cell Biology

$45,000

The Role of B cells in Obesity-related Insulin Resistance: Insulin as a key modulator of B cell function.

SupervisorCIHR2016CIHR Fellowship

Principal investigators: Clemente Casares, Javier

Keywords: B Cell; Humoral Response; Immunometabolism; Insulin Resistance; Obesity; Vaccination

$135,000

Immune Mechanisms of Hepatic Glucose Dysregulation in Diet Induced Obesity and Non-alcoholic Fatty Liver Disease

Nominated PICIHR2016Project Grant

Principal investigators: Winer, Daniel A

Keywords: Adaptive Immune System; Fatty Liver Disease; Innate Immune System; Insulin Resistance; Interferon; Liver; Metabolic Syndrome; Obesity; T Cells; Type 2 Diabetes

$100,000

Mechanisms of B cell Pathogenicity in Insulin Resistance

Nominated PICIHR2015Operating Grant

Principal investigators: Winer, Daniel A

Keywords: Adaptive Immune System; Antibodies; Antigen Specificity; B Cells; Innate Immune System; Insulin; Insulin Resistance; Metabolic Syndrome; Obesity; Type 2 Diabetes

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Department of Laboratory Medicine and Pathobiology
Department of Connective Tissue and Regenerative Medicine
Division of Anatomy
Department of Surgery
Anesthesia
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Hong-Shuo Sun

Division of Anatomy

1 shared papers, latest 2018

Annie Shrestha

Department of Connective Tissue and Regenerative Medicine

1 shared papers, latest 2023

Mingyao Liu

Department of Surgery

1 shared papers, latest 2011

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Insulin Resistance Dear Professor Winer, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Injectable thermosensitive hydrogel to modulate tolerogenic dendritic cells under hyperglycemic condition." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Investigating New Causes of T cell Aging" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Daniel Winer

Research

Latest papers

Latest funding

Injectable thermosensitive hydrogel to modulate tolerogenic dendritic cells under hyperglycemic condition.

Reversing CXCL10 Deficiency Ameliorates Kidney Disease in Diabetic Mice.

Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression.

Xanthomatous Hypophysitis Is Associated with Ruptured Rathke's Cleft Cyst.

Thyroglossal Duct Cyst Associated with Xanthogranulomatous Inflammation.

Images in endocrine pathology: papillary variant of medullary thyroid carcinoma with cystic change.

Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomas.

XB130, a novel adaptor protein, promotes thyroid tumor growth.

Osteopontin (OPN) expression in thyroid carcinoma.

Normalization of obesity-associated insulin resistance through immunotherapy

Investigating New Causes of T cell Aging

Sex-Dependent Intestinal Immune Mechanisms of Obesity Related Insulin Resistance

Understanding Simulated Microgravity Effects on Immune Cell Biology

Mechanisms of B cell mediated inflammation during aging

The Role of Intramuscular Immune Cell Infiltrations in Tumor and Age Related Muscle Wasting

The Immunological Impact of Direct Acting Antiviral Treatment for Early HCV Infection

Role of Insulin in T cell Function

The Role of B cells in Obesity-related Insulin Resistance: Insulin as a key modulator of B cell function.

Immune Mechanisms of Hepatic Glucose Dysregulation in Diet Induced Obesity and Non-alcoholic Fatty Liver Disease

Mechanisms of B cell Pathogenicity in Insulin Resistance

Frequent collaborators

Shereen Ezzat

Hong-Shuo Sun

Tianru Jin

Annie Shrestha

Rosanne St.Bernard

Ruslan Dorfman

Minna Woo

Mingyao Liu