Faculty profile

Christopher Yarnell

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Assistant ProfessorDepartment of MedicineUniversity of Toronto

Christopher Yarnell

Assistant Professor

Department of Medicine

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
6 publications in the last five years, latest in 2025.

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Academic metrics

Publications

122

Citations

Collaborators

Grants

Publications by year

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Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Eligibility Criteria of Randomized Clinical Trials in Critical Care Medicine
JAMA Network Open · 2025
Sedation practices in patients intubated in the emergency department compared with those in patients in the intensive care unit.
Critical care science · 2025
Observational studies of early versus late salvage therapies in critical care exhibit intrinsic selection bias: two meta-analyses
Critical Care · 2025

All 8 publications

Latest funding

Adjunctive Methylene Blue in Septic Shock (BLUSH) - A Multicentre Pilot Feasibility Trial
CIHR · 2026 · Co-investigator
$543,150
BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections
CIHR · 2025 · Co-investigator
$1,908,674
OVATION-CEPEC: Optimal VAsopressor titraTION within the Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC)
CIHR · 2025 · Co-investigator
$3,021,752

All 9 grants and awards

8 publications.

Eligibility Criteria of Randomized Clinical Trials in Critical Care Medicine

Heirali A, Heybati K, Sereeyotin J, Khan F, Yarnell C, Krewulak K, Murthy S, Burns KEA, Fowler R, Fiest K

JAMA Network Open202510 citationsOpen Access

DOI: 10.1001/jamanetworkopen.2024.54944

Sedation practices in patients intubated in the emergency department compared with those in patients in the intensive care unit.

Sereeyotin J, Yarnell C, Mehta S

Critical care science20255 citationsOpen Access

DOI: 10.62675/2965-2774.20250247 PMID: 40435028

Observational studies of early versus late salvage therapies in critical care exhibit intrinsic selection bias: two meta-analyses

Elizabeth Landzberg, Alexis Ogdie, Christopher J. Yarnell, Michael O. Harhay, Nadir Yehya

Critical Care20251 citationsOpen Access

DOI: 10.1186/s13054-025-05663-6 PMID: 41024133

Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation.

Mellado-Artigas R, Borrat X, Ferreyro BL, Yarnell C, Hao S, Wanis KN, Barbeta E, Torres A, Ferrando C, Brochard L

Critical care (London, England)202412 citationsOpen Access

DOI: 10.1186/s13054-024-04926-y PMID: 38730306

A Comparison of Palliative Care Delivery between Ethnically Chinese and Non-Chinese Canadians in the Last Year of Life.

Jia Z, Kurahashi A, Sharma RK, Mahtani R, Zagorski BM, Sanders JJ, Yarnell C, Detsky M, Lindvall C, Teno JM, Bell CM, Quinn KL

Journal of general internal medicine20245 citationsOpen Access

DOI: 10.1007/s11606-024-08859-8 PMID: 38926319

The impact of the COVID-19 pandemic on intensive care unit workers: a nationwide survey

Mehta S, Yarnell C, Shah S, Dodek P, Parsons-Leigh J, Maunder R, Kayitesi J, Eta-Ndu C, Priestap F, LeBlanc D

Canadian Journal of Anaesthesia202257 citationsOpen Access

DOI: 10.1007/s12630-021-02175-z

Measuring variability between clusters by subgroup: An extension of the median odds ratio.

Yarnell C, Pinto R, Fowler R

Statistics in medicine201932 citationsFirst author

DOI: 10.1002/sim.8286 PMID: 31359459

The case for routine goals-of-care documentation.

Yarnell C, Fowler R

BMJ quality & safety2016First author

DOI: 10.1136/bmjqs-2015-004776 PMID: 26669932

Adjunctive Methylene Blue in Septic Shock (BLUSH) - A Multicentre Pilot Feasibility Trial

Co-investigatorCIHR2026Project Grant

Principal investigators: Fernando, Shannon M; Rochwerg, Bram N; Soliman, Karim

Keywords: Critical Illness; Methylene Blue; Septic Shock

$543,150

BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections

Co-investigatorCIHR2025Project Grant

Principal investigators: Daneman, Nick; Fowler, Robert A; Johnstone, Jennie; Lee, Todd C; MacFadden, Derek R; McDonald, Emily G; Ong, Sean W; Pinto, Ruxandra; Rogers, Benjamin A

Keywords: Adaptive Platform Trial; Antibiotic De-Escalation; Antibiotic Duration; Antibiotic Oral Switch; Antimicrobial Resistance; Bloodstream Infection; Central Venous Catheter Infection; Gram Negative Bacteremia; Randomized Clinical Trial

$1,908,674

OVATION-CEPEC: Optimal VAsopressor titraTION within the Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC)

Co-investigatorCIHR2025Project Grant

Principal investigators: Lamontagne, Francois; Adhikari, Neill K; Slessarev, Marat

Keywords: Randomized Controlled Trial; Supportive Care; Usual Care; Vasopressor Therapy

$3,021,752

Platelet Transfusion Domain of the Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques - (CEPEC)

Co-investigatorCIHR2024Project Grant

Principal investigators: Lamontagne, Francois; Adhikari, Neill K; Arnold, Donald M; Callum, Jeannie L; Fowler, Robert A; Menon, Kusum; Tsang, Jennifer L

Keywords: Platelet Transfusion; Randomized Controlled Trial; Supportive Care

$1,193,400

Lung and Diaphragm Protection in Acute Hypoxemic Respiratory Failure: the LANDMARK II Pilot and Feasibility Randomized Clinical Trial

Co-investigatorCIHR2022Project Grant

Principal investigators: Goligher, Ewan C; Fan, Eddy

Keywords: Adaptive Platform Clinical Trial; Diaphragm-Protective Ventilation; Hypoxemic Respiratory Failure; Lung-Protective Ventilation

$339,660

BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects

Principal investigators: Daneman, Nick; Murthy, Srinivas; Yamamura, Deborah L; Fowler, Robert A; Johnstone, Jennie; Lee, Todd C; MacFadden, Derek R; McDonald, Emily G; Paterson, David L; Rogers, Benjamin A; Yahav, Dafna

Keywords: Adaptive Platform Trial; Antibiotic De-Escalation; Antibiotic Step-Down; Antimicrobial Resistance; Bloodstream Infection; Central Venous Catheter Infection; Gram Negative Bacteremia; Randomized Controlled Trial

$2,919,785

BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects - Indirect Costs

$729,947

Lung and Diaphragm Protection in Acute Hypoxemic Respiratory Failure: the LANDMARK II Pilot and Feasibility Randomized Clinical Trial

Co-investigatorCIHR2021Project Grant - PA: Patient-Oriented Research: Early-Career Investigator

Principal investigators: Goligher, Ewan C; Fan, Eddy

Keywords: Adaptive Platform Clinical Trial; Diaphragm-Protective Ventilation; Hypoxemic Respiratory Failure; Lung-Protective Ventilation

$100,000

Lung and Diaphragm Protection in Acute Hypoxemic Respiratory Failure: the LANDMARK II Pilot and Feasibility Randomized Clinical Trial

Co-investigatorCIHR2021Project Grant - PA: Patient-Oriented Research: Early-Career Investigator

Principal investigators: Goligher, Ewan C; Fan, Eddy

Keywords: Diaphragm-Protective Ventilation; Hypoxemic Respiratory Failure; Lung-Protective Ventilation; Pilot Clinical Trial

$100,000

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Christopher Yarnell

Research

Latest papers

Latest funding

Eligibility Criteria of Randomized Clinical Trials in Critical Care Medicine

Sedation practices in patients intubated in the emergency department compared with those in patients in the intensive care unit.

Observational studies of early versus late salvage therapies in critical care exhibit intrinsic selection bias: two meta-analyses

Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation.

A Comparison of Palliative Care Delivery between Ethnically Chinese and Non-Chinese Canadians in the Last Year of Life.

The impact of the COVID-19 pandemic on intensive care unit workers: a nationwide survey

Measuring variability between clusters by subgroup: An extension of the median odds ratio.

The case for routine goals-of-care documentation.

Frequent collaborators

Sangeeta Mehta

Robert Fowler

Rob Fowler

Karen Burns

Kimia Honarmand

Robert Maunder

Chaim Bell

Peter Dodek

Kirsten Fiest

Laurent Brochard

Srinivas Murthy

Alexis Ogdie-Beatty

Jeanna Parsons Leigh

Michael Detsky

Kieran Quinn

Bruno Ferreyro

Justin Sanders

Ruxandra Pinto

Jennifer Tsang

Jeanna Leigh

Bram Rochwerg