Clifford Lingwood, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Is cholesterol both the lock and key to abnormal transmembrane signals in Autism Spectrum Disorder?
Lipids in health and disease · 2024 · first author
ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species.
Journal of lipid research · 2021 · senior author
Therapeutic Uses of Bacterial Subunit Toxins.
Toxins · 2021 · first author

All 9 publications

Latest funding

Underlying mechanisms of regulation of glycosphingolipid synthesis in cells
NSERC · 2012 · Principal investigator
$170,000
CIHR Training Program in Protein Folding and Interaction Dynamics: Principles and Diseases
CIHR · 2008 · Co-investigator
$1,950,000
Role of the glycosphingolipid, globotriaosyl ceramide in HIV infection
CIHR · 2008 · Nominated PI
$100,000

All 3 grants and awards

9 publications.

01

Is cholesterol both the lock and key to abnormal transmembrane signals in Autism Spectrum Disorder?

Lingwood C

Lipids in health and disease2024First author

DOI: 10.1186/s12944-024-02075-3 PMID: 38643132

02

ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species.

Budani M, Auray-Blais C, Lingwood C

Journal of lipid research202120 citationsSenior authorOpen Access

DOI: 10.1016/j.jlr.2021.100128 PMID: 34597626

03

Therapeutic Uses of Bacterial Subunit Toxins.

Lingwood C

Toxins2021First author

DOI: 10.3390/toxins13060378 PMID: 34073185

04

Synthesis of a novel photoactivatable glucosylceramide cross-linker.

Budani M, Mylvaganam M, Binnington B, Lingwood C

Journal of lipid research2016Senior author

DOI: 10.1194/jlr.d069609 PMID: 27412675

05

Endoplasmic Reticulum-Targeted Subunit Toxins Provide a New Approach to Rescue Misfolded Mutant Proteins and Revert Cell Models of Genetic Diseases.

Adnan H, Zhang Z, Park HJ, Tailor C, Che C, Kamani M, Spitalny G, Binnington B, Lingwood C

PloS one2016Senior author

DOI: 10.1371/journal.pone.0166948 PMID: 27935997

06

Verotoxin A subunit protects lymphocytes and T cell lines against X4 HIV infection in vitro.

Shi PL, Binnington B, Sakac D, Katsman Y, Ramkumar S, Gariepy J, Kim M, Branch DR, Lingwood C

Toxins20125 citationsSenior authorOpen Access

DOI: 10.3390/toxins4121517 PMID: 23242319

07

Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism.

Kamani M, Mylvaganam M, Tian R, Rigat B, Binnington B, Lingwood C

The Journal of biological chemistry2011Senior author

DOI: 10.1074/jbc.m110.207670 PMID: 21518770

08

Differential intracellular transport and binding of verotoxin 1 and verotoxin 2 to globotriaosylceramide-containing lipid assemblies.

Tam P, Mahfoud R, Nutikka A, Khine AA, Binnington B, Paroutis P, Lingwood C

Journal of cellular physiology2008Senior author

DOI: 10.1002/jcp.21456 PMID: 18446787

09

Soluble adamantyl glycosphingolipid analogs as probes of glycosphingolipid function.

Lingwood C, Sadacharan S, Abul-Milh M, Mylvaganum M, Peter M

Methods in molecular biology (Clifton, N.J.)2006First author

DOI: 10.1385/1-59745-167-3:305 PMID: 17072019

Underlying mechanisms of regulation of glycosphingolipid synthesis in cells

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Lingwood, Clifford

$170,000

CIHR Training Program in Protein Folding and Interaction Dynamics: Principles and Diseases

Co-investigatorCIHR2008Training Grant

Principal investigators: Houry, Walid A; Forman-Kay, Julie D

Keywords: Absorbance; Alzheimer; Analytical Ultracentrifugation; Bacterial Infection; Bioinformatics; Cancer; Chaperones; Circular Dichroism; Computational Biology; Disease; Fluorescence; Folding; Microscopes; Misfolding; Nmr; Parkinson; Prions; Protein-Protein Interactions; Proteins; Proteomics; Training; X-Ray

$1,950,000

Role of the glycosphingolipid, globotriaosyl ceramide in HIV infection

Nominated PICIHR2008Operating Grant

Principal investigators: Lingwood, Clifford A

Keywords: Chemokine Coreceptor Trafficking; Cholesterol Trafficking; Glycolipid Lysosomal Storage Diseases; Hiv Resistance; Intracellular Gsl Retrograde Trafficking; Nk Cells

$100,000

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Frequent collaborators

Department of Laboratory Medicine & Pathobiology
FMSS Département de pédiatrie
Status

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Jean Gariepy

Status

1 shared papers, latest 2012

Donald Branch

Department of Laboratory Medicine & Pathobiology

1 shared papers, latest 2012

Christiane Auray-Blais

FMSS Département de pédiatrie

1 shared papers, latest 2021

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Subject: Prospective PhD student Dear Professor Lingwood, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Is cholesterol both the lock and key to abnormal transmembrane signals in Autism Spectrum Disorder?" (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]