Faculty profile
Jean Gariepy
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Research
Latest papers
An Inhibitory Aptamer Against PDGF-C Overcomes Anti-VEGF Refractoriness and Reduces Choroidal Neovascularization and Fibrosis.
Investigative ophthalmology & visual science · 2026
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.
Signal transduction and targeted therapy · 2023
Glypican-6 stimulates intestinal elongation by simultaneously regulating Hedgehog and non-canonical Wnt signaling.
Matrix biology : journal of the International Society for Matrix Biology · 2020
Latest funding
- $696,152
Development of Sepsis-countering Biologics
CIHR · 2024 · Nominated PI
- $868,275
Development of gastrointestinal track-targeted biologics to improve the treatment of inflammatory bowel disease (IBD)
CIHR · 2021 · Nominated PI
- $10,000
29th Annual International CEA Symposium
CIHR · 2019 · Co-investigator
10 publications.
An Inhibitory Aptamer Against PDGF-C Overcomes Anti-VEGF Refractoriness and Reduces Choroidal Neovascularization and Fibrosis.
Chen R, Lu W, Zhu J, Huang L, Chen W, Huang G, Ren X, Sun Q, Hu J, Li J, Wang S, Kuang H, Lee C, Lu W, Xiong Z, Liu Y, Wang X, Prodeus A, Zhu X, Zhang Q, Li K, Deng A, Cao Y, Yao Y, Gariepy J, Liu X, Yang Z, Jiang Q, Li X
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.
Lee C, Chen R, Sun G, Liu X, Lin X, He C, Xing L, Liu L, Jensen LD, Kumar A, Langer HF, Ren X, Zhang J, Huang L, Yin X, Kim J, Zhu J, Huang G, Li J, Lu W, Chen W, Liu J, Hu J, Sun Q, Lu W, Fang L, Wang S, Kuang H, Zhang Y, Tian G, Mi J, Kang BA, Narazaki M, Prodeus A, Schoonjans L, Ornitz DM, Gariepy J, Eelen G, Dewerchin M, Yang Y, Ou JS, Mora A, Yao J, Zhao C, Liu Y, Carmeliet P, Cao Y, Li X
Glypican-6 stimulates intestinal elongation by simultaneously regulating Hedgehog and non-canonical Wnt signaling.
Shi W, Kaneiwa T, Cydzik M, Gariepy J, Filmus J
CD200 mimetic aptamer PEG-M49 markedly increases the therapeutic effects of pegylated liposomal doxorubicin in a mouse model of metastatic breast carcinoma: an effect independent of CD200 receptor 1.
Erin N, Dilmaç S, Curry A, Duymuş Ö, Tanriover G, Prodeus A, Gariepy J, Gorczynski RM
Enhancing Checkpoint Inhibitor Therapy with Ultrasound Stimulated Microbubbles.
Bulner S, Prodeus A, Gariepy J, Hynynen K, Goertz DE
Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling.
Capurro M, Izumikawa T, Suarez P, Shi W, Cydzik M, Kaneiwa T, Gariepy J, Bonafe L, Filmus J
Tn-MUC1 DC Vaccination of Rhesus Macaques and a Phase I/II Trial in Patients with Nonmetastatic Castrate-Resistant Prostate Cancer
Scheid E, Major P, Bergeron A, Finn OJ, Salter RD, Eady R, Yassine-Diab B, Favre D, Peretz Y, Landry C
Transcriptome-wide characterization of the endogenous miR-34A-p53 tumor suppressor network.
Samuel N, Wilson G, Id Said B, Pan A, Deblois G, Fischer NW, Alexandrova R, Casallo G, Paton T, Lupien M, Gariepy J, Merico D, Hudson TJ, Malkin D
Verotoxin A subunit protects lymphocytes and T cell lines against X4 HIV infection in vitro.
Shi PL, Binnington B, Sakac D, Katsman Y, Ramkumar S, Gariepy J, Kim M, Branch DR, Lingwood C
Optical studies of vaporization and stability of fluorescently labelled perfluorocarbon droplets.
Reznik N, Seo M, Williams R, Bolewska-Pedyczak E, Lee M, Matsuura N, Gariepy J, Foster FS, Burns PN
Development of Sepsis-countering Biologics
Principal investigators: Gariepy, Jean
Keywords: Biologics; Cd200r1; Immune Modulators; Immunotherapy; Protein Bispecifics; Protein Engineering; Sepsis; Vista
Development of gastrointestinal track-targeted biologics to improve the treatment of inflammatory bowel disease (IBD)
Principal investigators: Gariepy, Jean
Keywords: Anti-Inflammatory Agents; Anti-Tnf Alpha Agents; Bi-Specific Proteins; Carcinoembryonic Antigen; Crohn'S Disease; Intestinal Bowel Disease; Localized Delivery To The Gut; Single Chain Fv; Targeted Biologics; Ulcerative Colitis
29th Annual International CEA Symposium
Principal investigators: Gray-Owen, Scott D
Keywords: Angiogenesis; Cancer; Carcinoembryonic Antigen (Cea); Cea-Related Cell Adhesion Molecules (Ceacams); Cell Signaling; Diabetes; Infectious Disease; Pregnancy-Specific Glycoproteins
Discovery and development of VISTA antagonists that restore antitumor immunity
Principal investigators: Gariepy, Jean
Keywords: Antibodies; Cancer; Dna Aptamers; Immune Checkpoint Inhibitors; Immunotherapy; Nanobodies; Protein Therapeutics
Understanding and harnessing the therapeutic potential of VISTA: a PD-1-like negative immune checkpoint regulator
Principal investigators: Gariepy, Jean
Keywords: Anti-Inflammatory Agents; Aptamers; Cancer; Immune Checkpoint Inhibitors; Immunomodulation; Immunotherapy; Mass Spectrometry; Osteoarthritis; Protein Therapeutics; Receptor Identification
Design and in vivo delivery of novel anti-inflammatory agents
Principal investigators: Gariepy, Jean
Keywords: Aptamers; Cd200; Cd200r1; Immune Monitoring; Inflammation; Mouse Models; Peptides; Tnf Alpha
Development of SPARC mimetic peptides for targeting peritoneal metastasis of epithelial ovarian cancer
Principal investigators: Ringuette, Maurice
Investigating the intracellular routing mechanism of Pseudomonas aeruginosa Exotoxin A
Principal investigators: Mohammed, Arshiya
Keywords: Cell Lysate Pull Downs; Drug Delivery; Exotoxin A; Intracellular Routing; Lentiviral Shrna Screens; Protein Interactions; Pseudomonas Aeruginosa; Recombinant Proteins; Therapeutic Agents; Yeast Two-Hybrid Screens
Development of SPARC mimetic peptides for targeting peritoneal metastasis of epithelial ovarian cancer
Principal investigators: Ringuette, Maurice J
Keywords: Epithelial Ovarian Cancer
Discovery of cellular targets of ER-routed protein toxins
Principal investigators: Gariepy, Jean
Keywords: Bacterial Pahtogens; Drug Discovery; Mass Spectrometry; Peptide Synthesis; Proteomics; Ribosome Inactivating Proteins
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Sebastien Hotte and Som Mukherjee: 32 shared papers
- Ronan Foley and Sebastien Hotte: 2 shared papers
- Ronan Foley and Som Mukherjee: 2 shared papers
- Jean Gariepy and Jorge Filmus: 2 shared papers
- Mathieu Lupien and David Malkin: 2 shared papers
- David Malkin and Gavin Wilson: 2 shared papers
- Ronan Foley and Jean Gariepy: 1 shared paper
- Sebastien Hotte and Jean Gariepy: 1 shared paper
- Som Mukherjee and Jean Gariepy: 1 shared paper
- Jean Gariepy and Mathieu Lupien: 1 shared paper
- Jean Gariepy and David Malkin: 1 shared paper
- Jean Gariepy and Kullervo Hynynen: 1 shared paper
- Jean Gariepy and Naomi Matsuura: 1 shared paper
- Jean Gariepy and Gavin Wilson: 1 shared paper
- Mathieu Lupien and Gavin Wilson: 1 shared paper
- Department of Medical Biophysics
- Department of Oncology
- Pediatrics
- Department of Medical Imaging
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Jorge Filmus
Faculty
2 shared papers, latest 2020
Gavin Wilson
Faculty
1 shared papers, latest 2016
Mathieu Lupien
Department of Medical Biophysics
1 shared papers, latest 2016
David Malkin
Pediatrics
1 shared papers, latest 2016
Naomi Matsuura
Department of Medical Imaging
1 shared papers, latest 2012
Kullervo Hynynen
Department of Medical Biophysics
1 shared papers, latest 2019
Ronan Foley
Department of Oncology
1 shared papers, latest 2016
Sebastien Hotte
Department of Oncology
1 shared papers, latest 2016
Som Mukherjee
Department of Oncology
1 shared papers, latest 2016
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