Faculty profile

Federico Gaiti

Back to faculty

Assistant ProfessorDepartment of Medical BiophysicsUniversity of Toronto

Federico Gaiti

Assistant Professor

Department of Medical Biophysics

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
10 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (4 CIHR, 2 NSERC), most recently in 2025.
Supervised 3 trainees who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Education

PhD, evolutionary biology and genomics
Postdoctoral Fellow

Profiles and links

University Profile Personal Website Search on Google Scholar iDORCID

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Genomics Approaches Targets And Biomarkers Tumour Progression And Metastasis Breast Cancer Cancer Prevention Epithelial-Stromal Interactions Fibroblasts High-Risk Mutation Carriers

Latest papers

IFN-γ drives long-term bone marrow niche dysfunction following doxorubicin-based chemotherapy.
Blood · 2026
Methylation-based lineage tracing in cancer.
Blood · 2026 · senior author
A cellular epigenetic classification system for glioblastoma.
Neuro-oncology · 2026

All 10 publications

Latest funding

Therapeutic targeting of the tumour microenvironment in post-transplant lymphoproliferative disorder
CIHR · 2025 · Supervisor
$120,000
Functional properties and genetic dependencies of phenotypic plasticity in human triple-negative breast cancer
CIHR · 2025 · Co-investigator
$1,147,500
Identifying early cancer precursors in individuals at increased risk of developing lymphoma
CIHR · 2025 · Supervisor
$120,000

All 13 grants and awards

10 publications.

IFN-γ drives long-term bone marrow niche dysfunction following doxorubicin-based chemotherapy.

Li X, Aguilar-Navarro AG, Nader M, Jahangiri S, Lee HS, Edun G, Gower M, Yang D, Fernandez M, Lin B, Oh D, Farhat S, Phillips DM, Bartman S, Murray D, Kaszuba C, Kossinna P, Kamath M, Whyne C, Schwartz G, Bajaj J, Kislinger T, Zhou BO, Coutu D, Akens M, Changoor A, Mallevaey T, Gaiti F, Jones C, Naik S, Minden M, Arruda A, Hitzler J, Lee KJ, Kim YM, Adams RH, Sivara KK, Tikhonova AN

Blood2026

DOI: 10.1182/blood.2025030946 PMID: 42008378

Methylation-based lineage tracing in cancer.

Chen J, Wu BZ, Gaiti F

Blood2026Senior author

DOI: 10.1182/blood.2024028196 PMID: 41397346

A cellular epigenetic classification system for glioblastoma.

Silverbush D, Jürgensen L, Freeburg NF, Pooley CS, Boniolo F, Gaiti F, Suvà ML, Hovestadt V

Neuro-oncology2026

DOI: 10.1093/neuonc/noaf299 PMID: 41499453

Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration.

Wu Y, Wu BZ, Ellenbogen Y, Kant JBY, Yu P, Li X, Caloren L, Sotov V, Tran C, Restrepo M, Kushida M, Ayyadhury S, Kossinna P, Lau R, Habibi P, Mansouri S, Regala J, Durbic T, Aboualizadeh F, Tsao J, Ketela T, Pugh T, Butler MO, Wang BX, Dirks PB, Gao A, Zadeh G, Gaiti F

Developmental cell2025Senior author

DOI: 10.1016/j.devcel.2025.04.022 PMID: 40381621

Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs.

Hosseini M, Voisin V, Chegini A, Varesi A, Cathelin S, Ayyathan DM, Liu ACH, Yang Y, Wang V, Maher A, Grignano E, Reisz JA, D'Alessandro A, Young K, Wu Y, Fiumara M, Ferrari S, Naldini L, Gaiti F, Pai S, Egan G, Schimmer AD, Bader GD, Dick JE, Xie SZ, Trowbridge JJ, Chan SM

Nature2025

DOI: 10.1038/s41586-025-08871-w PMID: 40240595

Molecular correlates for HPV-negative head and neck cancer engraftment prognosticate patient outcomes.

Waas M, Karamboulas C, Wu BZ, Khan S, Poon S, Meens J, Govindarajan M, Khoo A, Mejia-Guerrero S, Ha A, Liu LY, Nixon KCJ, Walton J, Bratman SV, Huang SH, Goldstein D, Gaiti F, Ailles L, Kislinger T

Nature communications2024

DOI: 10.1038/s41467-024-55203-z PMID: 39738080

GoT-Splice protocol for multi-omics profiling of gene expression, cell-surface proteins, mutational status, and RNA splicing in human cells.

Ganesan S, Cortés-López M, Swett AD, Dai X, Hickey S, Chamely P, Hawkins AG, Juul S, Landau DA, Gaiti F

STAR protocols2024Senior author

DOI: 10.1016/j.xpro.2024.102966 PMID: 38512867

Metformin reduces the clonal fitness of Dnmt3a R878H hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state.

Hosseini M, Voisin V, Chegini A, Varesi A, Cathelin S, Ayyathan DM, Liu ACH, Yang Y, Wang V, Maher A, Grignano E, Reisz JA, D'Alessandro A, Young K, Wu Y, Fiumara M, Ferrari S, Naldini L, Gaiti F, Pai S, Schimmer AD, Bader GD, Dick JE, Xie SZ, Trowbridge JJ, Chan SM

Research square2024

DOI: 10.21203/rs.3.rs-3874821/v1 PMID: 38405837

Decoding Cancer Evolution: Integrating Genetic and Non-Genetic Insights.

Ashouri A, Zhang C, Gaiti F

Genes2023Senior author

DOI: 10.3390/genes14101856 PMID: 37895205

Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths.

Cortés-López M, Chamely P, Hawkins AG, Stanley RF, Swett AD, Ganesan S, Mouhieddine TH, Dai X, Kluegel L, Chen C, Batta K, Furer N, Vedula RS, Beaulaurier J, Drong AW, Hickey S, Dusaj N, Mullokandov G, Stasiw AM, Su J, Chaligné R, Juul S, Harrington E, Knowles DA, Potenski CJ, Wiseman DH, Tanay A, Shlush L, Lindsley RC, Ghobrial IM, Taylor J, Abdel-Wahab O, Gaiti F, Landau DA

Cell stem cell2023

DOI: 10.1016/j.stem.2023.07.012 PMID: 37582363

Therapeutic targeting of the tumour microenvironment in post-transplant lymphoproliferative disorder

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Zhao, Davidson Z

Keywords: Ex Vivo Cultures; Post-Transplant Lymphoma; Single-Cell Sequencing; Spatial Transcriptomics; Tumour Microenvironment

$120,000

Functional properties and genetic dependencies of phenotypic plasticity in human triple-negative breast cancer

Co-investigatorCIHR2025Project Grant

Principal investigators: Nguyen, Long V

Keywords: Cancer Stem Cell Biology; Clonal Heterogeneity; Human Breast Cancer; Single Cell Sequencing

$1,147,500

Identifying early cancer precursors in individuals at increased risk of developing lymphoma

SupervisorCIHR2025Doctoral Research Award - PA - Bioinformatics and Computational Biology

Principal investigators: Shiba, Yumika

Keywords: Autoimmune Disease; Bioinformatics; Cancer; Early Detection; Genomics; Lupus; Lymphoma; Machine Learning; Transcriptomics

$120,000

Mapping early ecosystem reprogramming in high-risk breast tissue for cancer prevention

Nominated PICIHR2025Project Grant

Principal investigators: Gaiti, Federico

Keywords: Breast Cancer; Cancer Prevention; Epithelial-Stromal Interactions; Fibroblasts; High-Risk Mutation Carriers; Hormonal Regulation; Organoid Models; Single-Cell Omics; Spatial Omics; Tumor Microenvironment

$1,067,175

Uncovering molecular targets in cancer precursors across the spectrum of high-risk breast tissue

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Onabote, Oladapo

Keywords: Breast Cancer; Early Prevention Of Cancer; Epigenetics; Genetic Carrier; High-Risk Patients; Molecular Profiling; Single-Cell Multiomics

$120,000

Mapping genotype-to-phenotype relationships with single-cell omics

Principal investigatorNSERC2023Discovery Launch Supplement

Principal investigators: Gaiti, Federico

$12,500

Developmental cellular origins of pediatric medulloblastoma

Co-investigatorCIHR2023CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Pai, Shraddha

Keywords: Childhood And Young Adult; Genomics Approaches ; Tumour Progression And Metastasis

$62,500

Early detection of pathogenic B cell clones in high-risk lymphoma patients

Nominated PICIHR2023CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Gaiti, Federico

Keywords: Genomics Approaches; Targets And Biomarkers; Tumour Progression And Metastasis

$62,500

Mapping genotype-to-phenotype relationships with single-cell omics

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Gaiti, Federico

Keywords: Cellular Phenotypes; Clonal Expansion; Genotype; Hematopoiesis; Hematopoietic Stem Cells; Lymphopoiesis; Microenvironment; Multiomics Technologies; Single Cell; Transcriptome

$90,000

Developmental epigenetic origins of Group 3 and 4 medulloblastoma

Co-investigatorCIHR2022Project Grant - Priority Announcement: Pediatric Cancer Research

Principal investigators: Pai, Shraddha

Keywords: Brain Cancer; Epigenomics; Genomics

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

Something wrong or missing on this profile? Suggest a correction

Federico Gaiti

Research

Latest papers

Latest funding

IFN-γ drives long-term bone marrow niche dysfunction following doxorubicin-based chemotherapy.

Methylation-based lineage tracing in cancer.

A cellular epigenetic classification system for glioblastoma.

Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration.

Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs.

Molecular correlates for HPV-negative head and neck cancer engraftment prognosticate patient outcomes.

GoT-Splice protocol for multi-omics profiling of gene expression, cell-surface proteins, mutational status, and RNA splicing in human cells.

Metformin reduces the clonal fitness of Dnmt3a R878H hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state.

Decoding Cancer Evolution: Integrating Genetic and Non-Genetic Insights.

Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths.

Therapeutic targeting of the tumour microenvironment in post-transplant lymphoproliferative disorder

Functional properties and genetic dependencies of phenotypic plasticity in human triple-negative breast cancer

Identifying early cancer precursors in individuals at increased risk of developing lymphoma

Mapping early ecosystem reprogramming in high-risk breast tissue for cancer prevention

Uncovering molecular targets in cancer precursors across the spectrum of high-risk breast tissue

Mapping genotype-to-phenotype relationships with single-cell omics

Developmental cellular origins of pediatric medulloblastoma

Early detection of pathogenic B cell clones in high-risk lymphoma patients

Mapping genotype-to-phenotype relationships with single-cell omics

Developmental epigenetic origins of Group 3 and 4 medulloblastoma

Frequent collaborators

Thomas Kislinger

Adele Changoor

Daniel Coutu

Gelareh Zadeh

Cari Whyne

Laurie Ailles

Thierry Mallevaey

Margarete Akens

Johann Hitzler

Trevor Pugh

Mark Minden

Gregory Schwartz

Federico Gaiti

Research

Latest papers

Latest funding

IFN-&#x3b3; drives long-term bone marrow niche dysfunction following doxorubicin-based chemotherapy.

Methylation-based lineage tracing in cancer.

A cellular epigenetic classification system for glioblastoma.

Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration.

Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs.

Molecular correlates for HPV-negative head and neck cancer engraftment prognosticate patient outcomes.

GoT-Splice protocol for multi-omics profiling of gene expression, cell-surface proteins, mutational status, and RNA splicing in human cells.

Metformin reduces the clonal fitness of Dnmt3a R878H hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state.

Decoding Cancer Evolution: Integrating Genetic and Non-Genetic Insights.

Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths.

Mapping genotype-to-phenotype relationships with single-cell omics

Mapping genotype-to-phenotype relationships with single-cell omics

Frequent collaborators

Thomas Kislinger

Adele Changoor

Daniel Coutu

Gelareh Zadeh

Cari Whyne

Laurie Ailles

Thierry Mallevaey

Margarete Akens

Johann Hitzler

Trevor Pugh

Mark Minden

Gregory Schwartz

IFN-γ drives long-term bone marrow niche dysfunction following doxorubicin-based chemotherapy.