Faculty profile

Trevor Pugh

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ProfessorDepartment of Medical BiophysicsUniversity of Toronto

Trevor Pugh

Professor

Department of Medical Biophysics

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Canada Research Chair in Translational Genomics

ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
19 publications in the last five years, latest in 2026.
Principal investigator on 8 research grants (8 CIHR), most recently in 2024.
Supervised 4 trainees who won CIHR awards, most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

513

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Education

Clinical Molecular Genetics Fellow (ACMG)
Postdoctoral Fellow
Postdoctoral Fellow
PhD
B.Sc.

Profiles and links

University Profile Personal Website Search on Google Scholar iDORCID

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Cancer Genomics Translational Research Hepatocellular Carcinoma Genomics Cell-Free Dna Crc Circulating Tumour Dna Multiple Myeloma

Latest papers

Comprehensive Genomic Analysis in Hereditary Adrenal and Extra-Adrenal Paragangliomas.
Endocrine pathology · 2026
PIKfyve inhibition in MM disrupts autophagy and lysosome function, increasing MHC expression and cholesterol metabolism.
Blood · 2026
Prognostic value of perioperative circulating tumor DNA in endometrial cancer: systematic review & meta-analysis.
Gynecologic oncology · 2026

All 28 publications

Latest funding

Characterizing meningioma heterogeneity and microenvironment for new therapeutic opportunities
CIHR · 2025 · Co-investigator
$787,952
The TITRATE (Tailored Intensity of Treatment with Radio(chemo)therapy After Timely Evaluation) study: Toward personalized de-escalated multimodal therapy for oropharynx cancer
CIHR · 2025 · Co-investigator
$1,071,000
Spatial Dynamics of Interferon Signaling within the Tumor Microenvironment
CIHR · 2025 · Co-investigator
$1,197,226

All 45 grants and awards

28 publications.

Comprehensive Genomic Analysis in Hereditary Adrenal and Extra-Adrenal Paragangliomas.

Purnaghshband H, Tuzlali E, Deka KB, Bruce JP, Farncombe KM, Gillies B, Prokopec SD, Pugh T, Redmond S, Redondo L, Wang H, Ezzat S, Mete O, Kim RH

Endocrine pathology2026

DOI: 10.1007/s12022-026-09930-2 PMID: 42635851

PIKfyve inhibition in MM disrupts autophagy and lysosome function, increasing MHC expression and cholesterol metabolism.

Bonolo de Campos C, He R, Pelino T, Abelman DD, Li Z, Lee DKC, Wang DY, St Paul M, Bruce J, Simpson CD, Wybeng-Groot L, Moran MF, Tiedemann R, Pugh T, Mak TW, Issakova O, Sepetov N, Trudel S, Stewart AK

Blood2026

DOI: 10.1182/blood.2025030061 PMID: 41191517

Prognostic value of perioperative circulating tumor DNA in endometrial cancer: systematic review & meta-analysis.

Ahmed A, Saini G, Ferguson SE, Fazelzad R, Li Q, Han K, Pugh T, Wong D, Kim RH, Hodgson A, Leung S, Jamieson A, McAlpine JN, Lindemann K, Siegenthaler F, Kim SR

Gynecologic oncology2026

DOI: 10.1016/j.ygyno.2025.12.008 PMID: 41420893

The Genetic and Molecular Analyses of Rare Candidate Germline BRIP1/FANCJ Variants Implicated in Hereditary Breast and Ovarian Cancers.

Alenezi WM, Milano L, Fierheller CT, Serruya C, Revil T, Oros KK, Bruce JP, Spiegelman D, Pugh T, Mes-Masson AM, Provencher D, Foulkes WD, El Haffaf Z, Rouleau G, Bouchard L, Greenwood CMT, Ragoussis J, Masson JY, Tonin PN

International journal of molecular sciences2026

DOI: 10.3390/ijms27021037 PMID: 41596682

Continuous versus Standard Palbociclib Treatment and Molecular Profiling of Solid Tissues and Liquid Biopsies in the CCTG MA.38 Trial in Advanced Breast Cancer.

Joy AA, Cheng N, Gelmon KA, Mates M, Desbiens C, Clemons M, Taylor S, Lemieux J, DeLuca A, Gasparini L, Lungu I, Soave D, Fortuna A, Pugh T, Liu SS, Bartlett JMS, Awadalla P, Spears M, Chen BE, Bayani J, Parulekar WR

Cancer research communications2025

DOI: 10.1158/2767-9764.crc-25-0346 PMID: 41123599

Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration.

Wu Y, Wu BZ, Ellenbogen Y, Kant JBY, Yu P, Li X, Caloren L, Sotov V, Tran C, Restrepo M, Kushida M, Ayyadhury S, Kossinna P, Lau R, Habibi P, Mansouri S, Regala J, Durbic T, Aboualizadeh F, Tsao J, Ketela T, Pugh T, Butler MO, Wang BX, Dirks PB, Gao A, Zadeh G, Gaiti F

Developmental cell2025

DOI: 10.1016/j.devcel.2025.04.022 PMID: 40381621

Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy.

Barnet MB, Jackson KJL, Masle-Farquhar E, Russell A, Burnett DL, Chye A, Jara CJ, Faulks M, Mawson A, Peters TJ, Brink R, Wright K, Allen I, Junankar S, Davis ID, Heller G, Khan Z, Bruce J, Yang C, Prokopec S, Pugh T, Behren A, Hold GL, Zhang F, Cooper WA, Gao B, Nagrial A, Joshua AM, John T, Peters G, Hui R, Boyer M, Blinman PL, Kao SC, Cebon J, Goodnow CC

Proceedings of the National Academy of Sciences of the United States of America2025

DOI: 10.1073/pnas.2314258122 PMID: 40623177

FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells.

Feng Y, Barbulescu P, Chana CK, Shirdarreh M, Yang H, Wu L, Mamand S, Kashem M, Zia A, Han M, Tsao J, Pugh T, Cescon D, Schatz DG, Sicheri F, Martin A, Pezo RC

Scientific reports2025

DOI: 10.1038/s41598-025-07723-x PMID: 40604025

Guidelines for the testing and reporting of cytogenetic results for risk stratification of multiple myeloma: a report of the Cancer Genomics Consortium Plasma Cell Neoplasm Working Group.

Lu X, Andersen EF, Banerjee R, Eno CC, Gonzales PR, Kumar S, Lager AM, Miron PM, Pugh T, Quintero-Rivera F, Thurston VC, Wolff DJ, Zhao J, Fonseca R, Baughn LB

Blood cancer journal2025

DOI: 10.1038/s41408-025-01286-w PMID: 40533444

PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites

Yadav M, AlQazzaz MA, Ciamponi FE, Ho JC, Maron MI, Sababi AM, MacLeod G, Ahmadi M, Bullivant G, Tano V

Nucleic Acids Research (NAR)20254 citations

DOI: 10.1093/nar/gkaf347

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Trevor Pugh

Research

Latest papers

Latest funding

Comprehensive Genomic Analysis in Hereditary Adrenal and Extra-Adrenal Paragangliomas.

PIKfyve inhibition in MM disrupts autophagy and lysosome function, increasing MHC expression and cholesterol metabolism.

Prognostic value of perioperative circulating tumor DNA in endometrial cancer: systematic review & meta-analysis.

The Genetic and Molecular Analyses of Rare Candidate Germline BRIP1/FANCJ Variants Implicated in Hereditary Breast and Ovarian Cancers.

Continuous versus Standard Palbociclib Treatment and Molecular Profiling of Solid Tissues and Liquid Biopsies in the CCTG MA.38 Trial in Advanced Breast Cancer.

Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration.

Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy.

FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells.

Guidelines for the testing and reporting of cytogenetic results for risk stratification of multiple myeloma: a report of the Cancer Genomics Consortium Plasma Cell Neoplasm Working Group.

PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites

Frequent collaborators

Parisa Shooshtari

Vijay Ramaswamy

Stephanie Lheureux

Phedias Diamandis

Sheila Singh

David Malkin

Ming-Sound Tsao

Nada Jabado

Jordan Lerner-Ellis

Luigi Bouchard

Guy Rouleau

Luigi Bouchard

Anne-Marie Mes-Masson

Michael Brudno

Philip Awadalla

Livia Garzia

Stanley Liu

Anna Spreafico

David Cescon

Adrian Sacher

Eric Bouffet

Jüri Reimand

Jennifer Taher

Ute Bartels

Kathy Han

Federico Gaiti

Dalia Barsyte-Lovejoy

Amy Jamieson

Robert Kridel

Livia Garzia

Steven Gallinger

Gelareh Zadeh

Alberto Martin

Shereen Ezzat

Nicholas Bock

Sohrab Shah

Mark Clemons

Yvonne Bombard

Inanc Birol

Lincoln Stein