Golnaz Karoubi, University of Toronto

Research

Epithelial Cells Airway Stem Cells Bioengineered Lungs Biological Scaffold Decellularization Lung Transplantation Mechanical Stretch Recellularization

Latest papers

Advances in lung biomimetic systems: exploring biophysical cues in lung regenerative medicine.
Trends in biotechnology · 2026 · senior author
Automated Abnormal Vessel Detection in Re-Endothelialized Mouse Lungs: A Proof of Concept.
Tissue engineering. Part C, Methods · 2026
Tracheal Regeneration: Recent Progress in the Application of Stem Cells in Tracheal Bioengineering.
International journal of molecular sciences · 2026 · senior author

All 39 publications

Latest funding

Advancing Lung Recellularization Through Scaffold Modulation via Mechanical Stretch: A Pathway to Functional Grafts
CIHR · 2026 · Nominated PI
$918,000
The use of immune-modified FailSafe cells as a cell replacement therapy for cystic fibrosis
CIHR · 2025 · Supervisor
$120,000
Melt electrowrite system for biofabrication of complex engineered tissues
NSERC · 2023 · Co-investigator
$150,000

All 8 grants and awards

39 publications.

01

Advances in lung biomimetic systems: exploring biophysical cues in lung regenerative medicine.

Bian S, Say J, Brinson D, Karoubi G

Trends in biotechnology2026Senior author

DOI: 10.1016/j.tibtech.2025.11.009 PMID: 41354607

02

Automated Abnormal Vessel Detection in Re-Endothelialized Mouse Lungs: A Proof of Concept.

Paciocco J, Hasan A, Chan J, Taniguchi D, Kamata S, Amon C, Karoubi G, Bazylak A

Tissue engineering. Part C, Methods2026

DOI: 10.1177/19373384261458003 PMID: 42261753

03

Tracheal Regeneration: Recent Progress in the Application of Stem Cells in Tracheal Bioengineering.

Ganji F, Le Billan F, Haykal S, Karoubi G

International journal of molecular sciences2026Senior author

DOI: 10.3390/ijms27062891 PMID: 41898750

04

Breast Tissue Reconstruction Strategies: A Tissue Engineering Approach.

Stoian A, Duru Ç, Chogan F, Biniazan F, Temple B, Karoubi G, Haykal S

Tissue engineering. Part B, Reviews2026

DOI: 10.1177/19373341251372961 PMID: 40910925

05

24-hour ex vivo perfusion of vascularized composite allografts in a large animal total limb model.

Duru Ç, Stoian A, Biniazan F, Le Billan F, Karoubi G, Keshavjee S, Haykal S

Frontiers in transplantation2026

DOI: 10.3389/frtra.2026.1718484 PMID: 41768143

06

In silico modeling of anterior foregut endoderm differentiation towards lung epithelial progenitors.

Mostofinejad A, Romero DA, Brinson D, Waddell TK, Karoubi G, Amon CH

NPJ systems biology and applications2026

DOI: 10.1038/s41540-026-00650-1 PMID: 41588005

07

Anti-CD31 antibody preconditioning for enhancement of endothelial cell capture and vascularization: a novel strategy for bioengineering lung scaffolds.

Kamata S, Zargar A, Taniguchi D, Suzuki Y, Lo A, Bian S, Chen E, Ligi S, Keshavjee S, Okada Y, Haykal S, Bazylak A, Waddell TK, Karoubi G

Journal of biological engineering2026Senior author

DOI: 10.1186/s13036-025-00593-x PMID: 41507974

08

Recent Advancements in the Generation and Application of Therapeutic Cell Populations for Lung Epithelial Repair.

Zhou M, Brinson D, Lei C, Karoubi G

Journal of tissue engineering and regenerative medicine2025Senior author

DOI: 10.1155/term/8367426 PMID: 41479466

09

High-throughput isolation of normal and pulmonary fibrosis human alveolar epithelial cells.

Eiliazadeh AL, Suma MAV, Li J, Cuesta M, Ishaq J, Taniguchi D, Keshavjee S, Waddell TK, Karoubi G

Scientific reports2025Senior author

DOI: 10.1038/s41598-025-30242-8 PMID: 41339680

10

Ex vivo perfusion recellularization of acellular rat hindlimbs for vascular composite allotransplantation.

Adil A, Biniazan F, Shamoun V, Karoubi G, Haykal S

Scientific reports2025

DOI: 10.1038/s41598-025-25223-w PMID: 41272043

Advancing Lung Recellularization Through Scaffold Modulation via Mechanical Stretch: A Pathway to Functional Grafts

Nominated PICIHR2026Project Grant

Principal investigators: Karoubi, Golnaz

Keywords: Airway Stem Cells; Bioengineered Lungs; Biological Scaffold; Decellularization; Epithelial Cells; Lung Transplantation; Mechanical Stretch; Recellularization; Scaffolds; Stem Cell Differentiation

$918,000

The use of immune-modified FailSafe cells as a cell replacement therapy for cystic fibrosis

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Zhou, Muyang

Keywords: Cell Replacement Therapy; Cftr; Cystic Fibrosis; Lung Development; Lung Regeneration; Pluripotent Stem Cells

$120,000

Melt electrowrite system for biofabrication of complex engineered tissues

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Simmons, Craig

$150,000

Improving stem cell-derived distal lung organoids using a biomimetic culture platform

SupervisorCIHR2023Travel Awards - Institute Community Support

Principal investigators: Brinson, Dana

Keywords: Ics Travel Awards

$1,500

Generation of Non-Immunogenic Human Tracheal Grafts for Transplantation

Nominated PICIHR2022Project Grant

Principal investigators: Karoubi, Golnaz; Haykal, Siba

Keywords: Airway Patches; Airway Regeneration; Biological Scaffolds; Cell Therapy; Designer Cells; Epithelial Cells; Human Induced Pluripotent Stem Cells; Immunology; Trachea; Transplantation

$757,350

Use of Bioengineered Vascular Composite Allografts for Tracheal Revascularization

Co-investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Haykal, Siba

Keywords: Tracheal Regeneration; Vascular Composite Allografts; Bioreactor; Biomimetic Culture Systems; Endothelialization; Vascularization; Transplantation

$125,000

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Keshavjee, Shaf

Keywords: Immunology; Immunotolerance; Organ transplantation; Ex vivo organ perfusion; Gene modification; Cell therapy; Translational research; Organ repair; Medical ethics; Biomedical engineering; Patient-centred approach; Precision medicine

$8,000,000

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Keshavjee, Shaf

Keywords: Immunology Immunotolerance Organ transplantation Ex vivo organ perfusion Gene modification Cell therapy Translational research Organ repair Medical ethics Biomedical engineering Patient-centred approach Precision medicine

$8,000,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Laboratory Medicine & Pathobiology
Plastic Surgery
Mechanical and Industrial Engineering
Thoracic Surgery
Lunenfeld-Tanenbaum Research Institute
Molecular Medicine
Medicine/Respirology

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Siba Haykal

Plastic Surgery

14 shared papers, latest 2026

Cristina Amon

Mechanical and Industrial Engineering

5 shared papers, latest 2026

Shaf Keshavjee

Thoracic Surgery

4 shared papers, latest 2026

Andras Nagy

Lunenfeld-Tanenbaum Research Institute

2 shared papers, latest 2018

John Granton

Medicine/Respirology

1 shared papers, latest 2006

Christine Bear

Molecular Medicine

1 shared papers, latest 2017

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Epithelial Cells Dear Professor Karoubi, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Advances in lung biomimetic systems: exploring biophysical cues in lung regenerative medicine." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Advancing Lung Recellularization Through Scaffold Modulation via Mechanical Stretch: A Pathway to Functional Grafts" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]