Siba Haykal, University of Toronto

Research

Airway Patches Airway Regeneration Biological Scaffolds Cell Therapy Designer Cells Epithelial Cells Human Induced Pluripotent Stem Cells Immunology

Latest papers

Tracheal Regeneration: Recent Progress in the Application of Stem Cells in Tracheal Bioengineering.
International journal of molecular sciences · 2026
Breast Tissue Reconstruction Strategies: A Tissue Engineering Approach.
Tissue engineering. Part B, Reviews · 2026 · senior author
24-hour ex vivo perfusion of vascularized composite allografts in a large animal total limb model.
Frontiers in transplantation · 2026 · senior author

All 46 publications

Latest funding

Use of Bioengineered Vascular Composite Allografts for Tracheal Revascularization
SSHRC · 2022 · Principal investigator
$125,000
Generation of Non-Immunogenic Human Tracheal Grafts for Transplantation
CIHR · 2022 · Principal investigator
$757,350
Use of Bioengineered Vascular Composite Allografts for Tracheal Revascularization
SSHRC · 2022 · Principal investigator
$125,000

All 7 grants and awards

46 publications.

01

Tracheal Regeneration: Recent Progress in the Application of Stem Cells in Tracheal Bioengineering.

Ganji F, Le Billan F, Haykal S, Karoubi G

International journal of molecular sciences2026

DOI: 10.3390/ijms27062891 PMID: 41898750

02

Breast Tissue Reconstruction Strategies: A Tissue Engineering Approach.

Stoian A, Duru Ç, Chogan F, Biniazan F, Temple B, Karoubi G, Haykal S

Tissue engineering. Part B, Reviews2026Senior author

DOI: 10.1177/19373341251372961 PMID: 40910925

03

24-hour ex vivo perfusion of vascularized composite allografts in a large animal total limb model.

Duru Ç, Stoian A, Biniazan F, Le Billan F, Karoubi G, Keshavjee S, Haykal S

Frontiers in transplantation2026Senior author

DOI: 10.3389/frtra.2026.1718484 PMID: 41768143

04

Intraoperative Umbilical Perfusion Assessment Following Deep Inferior Epigastric Perforator Breast Reconstruction Using Indocyanine Green.

Hadzimustafic N, Avery E, Chen J, Zeidan M, Haykal S

Plastic and reconstructive surgery. Global open2026Senior author

DOI: 10.1097/gox.0000000000007397 PMID: 41523925

05

Anti-CD31 antibody preconditioning for enhancement of endothelial cell capture and vascularization: a novel strategy for bioengineering lung scaffolds.

Kamata S, Zargar A, Taniguchi D, Suzuki Y, Lo A, Bian S, Chen E, Ligi S, Keshavjee S, Okada Y, Haykal S, Bazylak A, Waddell TK, Karoubi G

Journal of biological engineering2026

DOI: 10.1186/s13036-025-00593-x PMID: 41507974

06

Ex vivo perfusion recellularization of acellular rat hindlimbs for vascular composite allotransplantation.

Adil A, Biniazan F, Shamoun V, Karoubi G, Haykal S

Scientific reports2025Senior author

DOI: 10.1038/s41598-025-25223-w PMID: 41272043

07

A Prospective Study of the Impact of Lymphatic Venous Anastomosis as a Treatment for Lymphedema.

Bowman C, Hircock C, Haykal S

Plastic and reconstructive surgery. Global open2025Senior author

DOI: 10.1097/gox.0000000000007088 PMID: 40977877

08

Evaluating the immunogenicity of a mouse partial hindlimb for composite allotransplantation.

Sun JHA, Ligi S, Biniazan F, Haykal S

Frontiers in immunology2025Senior author

DOI: 10.3389/fimmu.2025.1595319 PMID: 40607410

09

Human-Induced Pluripotent Stem Cells in Plastic and Reconstructive Surgery.

Hadzimustafic N, D'Elia A, Shamoun V, Haykal S

International journal of molecular sciences2024Senior author

DOI: 10.3390/ijms25031863 PMID: 38339142

10

Two Decades of Advances and Limitations in Organ Recellularization.

Stoian A, Adil A, Biniazan F, Haykal S

Current issues in molecular biology2024Senior author

DOI: 10.3390/cimb46080543 PMID: 39194760

Use of Bioengineered Vascular Composite Allografts for Tracheal Revascularization

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Haykal, Siba

Keywords: Tracheal Regeneration Vascular Composite Allografts Bioreactor Biomimetic Culture Systems Endothelialization Vascularization Transplantation

$125,000

Generation of Non-Immunogenic Human Tracheal Grafts for Transplantation

Principal investigatorCIHR2022Project Grant

Principal investigators: Karoubi, Golnaz; Haykal, Siba

Keywords: Airway Patches; Airway Regeneration; Biological Scaffolds; Cell Therapy; Designer Cells; Epithelial Cells; Human Induced Pluripotent Stem Cells; Immunology; Trachea; Transplantation

$757,350

Use of Bioengineered Vascular Composite Allografts for Tracheal Revascularization

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Haykal, Siba

Keywords: Tracheal Regeneration; Vascular Composite Allografts; Bioreactor; Biomimetic Culture Systems; Endothelialization; Vascularization; Transplantation

$125,000

The characterization and therapeutic targeting of aberrant metabolic and inflammatory signaling in chronic lymphedema

Co-investigatorCIHR2021Project Grant

Principal investigators: Liu, Fei-Fei

Keywords: Inflammation; Lymphedema; Metabolism; Pharmacogenomics; Therapeutics; Treatment-Related Side Effects

$971,550

The characterization and therapeutic targeting of metabolic and inflammatory signaling in chronic lymphedema

Co-investigatorCIHR2020Project Grant - Priority Announcement: Infection and Immunity

Principal investigators: Liu, Fei-Fei

Keywords: Inflammation; Lymphedema; Metabolism; Pharmacogenomics; Therapeutics; Treatment-Related Side Effects

$100,000

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Keshavjee, Shaf

Keywords: Immunology; Immunotolerance; Organ transplantation; Ex vivo organ perfusion; Gene modification; Cell therapy; Translational research; Organ repair; Medical ethics; Biomedical engineering; Patient-centred approach; Precision medicine

$8,000,000

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Keshavjee, Shaf

Keywords: Immunology Immunotolerance Organ transplantation Ex vivo organ perfusion Gene modification Cell therapy Translational research Organ repair Medical ethics Biomedical engineering Patient-centred approach Precision medicine

$8,000,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Plastic Surgery
Thoracic Surgery
Laboratory Medicine & Pathobiology
Department of Surgery
Toronto General Research Institute
Pediatrics
Mechanical Engineering
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Golnaz Karoubi

Laboratory Medicine & Pathobiology

14 shared papers, latest 2026

Shaf Keshavjee

Thoracic Surgery

5 shared papers, latest 2026

Toni Zhong

Department of Surgery

5 shared papers, latest 2023

Stephen Juvet

Toronto General Research Institute

2 shared papers, latest 2023

Anne Klassen

Pediatrics

1 shared papers, latest 2023

Cristina Amon

Mechanical and Industrial Engineering

1 shared papers, latest 2019

Armand Keating

Mechanical Engineering

1 shared papers, latest 2013

An-Wen Chan

Faculty

1 shared papers, latest 2023

Natalia Ziolkowski

Surgery

1 shared papers, latest 2024

Stefan Hofer

Plastic Surgery

1 shared papers, latest 2016

Marcelo Cypel

Thoracic Surgery

1 shared papers, latest 2023

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their SSHRC grant from 2022

Subject: Prospective PhD student: Airway Patches Dear Professor Haykal, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Tracheal Regeneration: Recent Progress in the Application of Stem Cells in Tracheal Bioengineering." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your SSHRC-funded project "Use of Bioengineered Vascular Composite Allografts for Tracheal Revascularization" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]