Faculty profile

Herbert Gaisano

ResearcherMedicineUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Herbert Gaisano

Researcher

Medicine

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
4 publications in the last five years, latest in 2023.
Principal investigator on 10 research grants (10 CIHR), most recently in 2022.
Supervised 3 trainees who won CIHR awards, most recently in 2011.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Snare Proteins Non-Alcoholic Fatty Liver Disease Fecal Microbiota Transplant Intestinal Microbiome Electrophysiology Anti-Fibrosis Drug Glucagon-Like Peptide 1 Crc

Latest papers

Post-Load Insulin Secretion Patterns are Associated with Glycemic Status and Diabetic Complications in Patients with Type 2 Diabetes Mellitus.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2023
Design of a versatile microfluidic device for imaging precision-cut-tissue slices.
Biofabrication · 2022
A live-imaging protocol for tracking receptor dynamics in single cells.
STAR protocols · 2022

All 22 publications

Latest funding

The ELDER Study: Timing cancer by tracking how tissue-specific aging shapes malignancy
CIHR · 2025 · Co-investigator
$2,000,000
Stage-specific treatment of human non-alcoholic fatty liver disease: elucidating the precise mechanisms of actions of glucagon-like peptide-1 receptor agonists and novel anti-fibrosis molecules
CIHR · 2022 · Nominated PI
$1,116,900
Canada Research Chairs - Tier 1
CIHR · 2019 · Nominated PI
$1,400,000

All 16 grants and awards

22 publications.

Post-Load Insulin Secretion Patterns are Associated with Glycemic Status and Diabetic Complications in Patients with Type 2 Diabetes Mellitus.

Jiang J, Li Y, Li F, He Y, Song L, Wang K, You W, Xia Z, Zuo Y, Su X, Zhai Q, Zhang Y, Gaisano H, Zheng D

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association2023

DOI: 10.1055/a-2018-4299 PMID: 36796421

Design of a versatile microfluidic device for imaging precision-cut-tissue slices.

Rafiei N, Moghadam MG, Au A, Regeenes R, Chidambaram S, Liang T, Wang Y, Yip CM, Gaisano H, Rocheleau JV

Biofabrication2022

DOI: 10.1088/1758-5090/ac7eea PMID: 35793653

A live-imaging protocol for tracking receptor dynamics in single cells.

Huang Y, Takahashi T, Gaisano H, Rakugi H, Yamamoto K

STAR protocols2022

DOI: 10.1016/j.xpro.2022.101347 PMID: 35509972

Association between changes in lipid indexes and early progression of kidney dysfunction in participants with normal estimated glomerular filtration rate: a prospective cohort study.

Zhai Q, Dou J, Wen J, Wang M, Zuo Y, Su X, Zhang Y, Gaisano H, Mu Y, He Y

Endocrine2022

DOI: 10.1007/s12020-022-03012-z PMID: 35239125

Glomerular Hyperfiltration Interacts With Abnormal Metabolism to Enhance Arterial Stiffness in Middle-Aged and Elderly People.

Zhai Q, Wen J, Wang M, Zuo Y, Su X, Zhang Y, Gaisano H, He Y

Frontiers in medicine2021

DOI: 10.3389/fmed.2021.732413 PMID: 34746175

Clinical Characteristics and Long-term Outcomes of Children With Fibrosing Pancreatitis.

Scheers I, Chavhan GB, Chami R, Carman N, Scaini V, Gaisano H, Marcon M, Gonska T

Journal of pediatric gastroenterology and nutrition2020

DOI: 10.1097/mpg.0000000000002726 PMID: 32443035

Risk of chronic kidney disease defined by decreased estimated glomerular filtration rate in individuals with different prediabetic phenotypes: results from a prospective cohort study in China.

Li W, Wang A, Jiang J, Liu G, Wang M, Li D, Wen J, Mu Y, Du X, Gaisano H, Dou J, He Y

BMJ open diabetes research & care2020

DOI: 10.1136/bmjdrc-2019-000955 PMID: 32245825

Relationship of obesity to adipose tissue insulin resistance.

Jiang J, Cai X, Pan Y, Du X, Zhu H, Yang X, Zheng D, Gaisano H, Wei T, He Y

BMJ open diabetes research & care2020

DOI: 10.1136/bmjdrc-2019-000741 PMID: 32245824

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis.

Cornick S, Kumar M, Moreau F, Gaisano H, Chadee K

Nature communications2019

DOI: 10.1038/s41467-019-11811-8 PMID: 31541089

Gut-associated IgA+ immune cells regulate obesity-related insulin resistance.

Luck H, Khan S, Kim JH, Copeland JK, Revelo XS, Tsai S, Chakraborty M, Cheng K, Tao Chan Y, Nøhr MK, Clemente-Casares X, Perry MC, Ghazarian M, Lei H, Lin YH, Coburn B, Okrainec A, Jackson T, Poutanen S, Gaisano H, Allard JP, Guttman DS, Conner ME, Winer S, Winer DA

Nature communications2019

DOI: 10.1038/s41467-019-11370-y PMID: 31409776

The ELDER Study: Timing cancer by tracking how tissue-specific aging shapes malignancy

Co-investigatorCIHR2025Team Grant: Bringing Bio to Cancer Prev- Int Japan-Canada Geroscience

Principal investigators: Notta, Faiyaz; Gallinger, Steven; Grant, Robert; Lupien, Mathieu; Yachida, Shinichi

Keywords: Aging; Clonal Evolution; Colorectal Cancer; Early-Onset; Endogenous Retroviral Elements; Epigenetic; Metabolic Reprogramming; Microbiome; Pancreatic Ductal Adenocarcinoma; Patient-Derived Organoid

$2,000,000

Stage-specific treatment of human non-alcoholic fatty liver disease: elucidating the precise mechanisms of actions of glucagon-like peptide-1 receptor agonists and novel anti-fibrosis molecules

Nominated PICIHR2022Project Grant

Principal investigators: Gaisano, Herbert Y; Yuen, Darren A

Keywords: Anti-Fibrosis Drug; Glucagon-Like Peptide 1; Non-Alcoholic Fatty Liver Disease

$1,116,900

Canada Research Chairs - Tier 1

Nominated PICIHR2019Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Gaisano, Herbert Y

Keywords: Crc

$1,400,000

Novel excitosomes mediating exocytosis in neuroendocrine cells

Nominated PICIHR2018Project Grant

Principal investigators: Gaisano, Herbert Y

Keywords: Calcium Channels; Electrophysiology; Exocytosis; Insulin Granule Exocytosis; Islet Beta Cells; Potassium Channels; Reserve Pool; Snare Proteins; Tirf-Sim Microscopy

$872,100

Assessing the role and preventative or therapeutic effects of Faecalibacterium prausnitzii and other candidate bacteria in non-alcoholic fatty liver disease

Principal investigatorCIHR2018Team Grant: Canadian Microbiome Initiative 2: Research Teams - LOI

Principal investigators: Allard, Johane P; Bhat, Mamatha; Gaisano, Herbert Y; Hota, Susy S; Philpott, Dana J; Poutanen, Susan M

Keywords: Fecal Microbiota Transplant; Human; Intestinal Microbiome; Liver Transplant; Metabolic Syndrome; Mice; Non-Alcoholic Fatty Liver Disease; Nutrition; Prebiotics; Probiotics

$25,000

Role of autophagy dysregulation in pancreatitis caused by alcohol and glucagon-like peptide

Nominated PICIHR2018Project Grant

Principal investigators: Gaisano, Herbert Y

Keywords: Alcoholic Pancreatitis; Autophagy; Glp-1 Induced Pancreatitis; Human Pancreas; Snare Proteins

$891,226

alpha-cell glucagon secretion: regulated exocytosis, dysregulation & rescue of type-1 diabetes

Nominated PICIHR2016Project Grant

Principal investigators: Gaisano, Herbert Y

Keywords: Adeno-Associated Virus; Electrophysiology; Glucagon Secretion; Human Islets; Multi-Photon Microscopy; Pancreatic Islet Alpha Cells; Snare Proteins; Tirf Microscopy; Type-1 Diabetes

$783,615

Exploiting the therapeutic effects of the fecal microbiome in bariatric care

Principal investigatorCIHR2014Team Grant: Bariatric Care - Mechanisms underlying bariatric procedures

Principal investigators: Allard, Johane P; Gaisano, Herbert Y

Keywords: Bariatric Surgery; Fecal Microbiota Transplant; Intestinal Microbiome; Metagenome

$1,375,000

Rescuing the insulin exocytotic defects in type 2 diabetes

Nominated PICIHR2012Operating Grant

Principal investigators: Gaisano, Herbert Y

Keywords: Cytoskeleton; Diabetes; Evanescent Microscopy; Insulin Exocytosis; Lentivirus; Multiphoton Microscopy; Patch Clamp Electrophysiology; Snare Proteins

$699,905

Mechanisms of pancreatitis elucidated on human pancreas in situ

Nominated PICIHR2011Operating Grant

Principal investigators: Gaisano, Herbert Y

Keywords: Alcoholic Pancreatitis; Glucagon Like Peptide 1; Human Pancreas; Pathologic Exocytosis; Snare Proteins

$762,885

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

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Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Snare Proteins Dear Professor Gaisano, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Post-Load Insulin Secretion Patterns are Associated with Glycemic Status and Diabetic Complications in Patients with Type 2 Diabetes Mellitus." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Stage-specific treatment of human non-alcoholic fatty liver disease: elucidating the precise mechanisms of actions of glucagon-like peptide-1 receptor agonists and novel anti-fibrosis molecules" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Herbert Gaisano

Research

Latest papers

Latest funding

Post-Load Insulin Secretion Patterns are Associated with Glycemic Status and Diabetic Complications in Patients with Type 2 Diabetes Mellitus.

Design of a versatile microfluidic device for imaging precision-cut-tissue slices.

A live-imaging protocol for tracking receptor dynamics in single cells.

Association between changes in lipid indexes and early progression of kidney dysfunction in participants with normal estimated glomerular filtration rate: a prospective cohort study.

Glomerular Hyperfiltration Interacts With Abnormal Metabolism to Enhance Arterial Stiffness in Middle-Aged and Elderly People.

Clinical Characteristics and Long-term Outcomes of Children With Fibrosing Pancreatitis.

Risk of chronic kidney disease defined by decreased estimated glomerular filtration rate in individuals with different prediabetic phenotypes: results from a prospective cohort study in China.

Relationship of obesity to adipose tissue insulin resistance.

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis.

Gut-associated IgA+ immune cells regulate obesity-related insulin resistance.

The ELDER Study: Timing cancer by tracking how tissue-specific aging shapes malignancy

Stage-specific treatment of human non-alcoholic fatty liver disease: elucidating the precise mechanisms of actions of glucagon-like peptide-1 receptor agonists and novel anti-fibrosis molecules

Canada Research Chairs - Tier 1

Novel excitosomes mediating exocytosis in neuroendocrine cells

Assessing the role and preventative or therapeutic effects of Faecalibacterium prausnitzii and other candidate bacteria in non-alcoholic fatty liver disease

Role of autophagy dysregulation in pancreatitis caused by alcohol and glucagon-like peptide

alpha-cell glucagon secretion: regulated exocytosis, dysregulation & rescue of type-1 diabetes

Exploiting the therapeutic effects of the fecal microbiome in bariatric care

Rescuing the insulin exocytotic defects in type 2 diabetes

Mechanisms of pancreatitis elucidated on human pancreas in situ

Frequent collaborators

Minna Woo

Bryan Coburn

Tianru Jin

Timothy Jackson

Susan Poutanen

Sue Tsai

Tanja Gonska

Marc Prentki