Faculty profile

Bryan Coburn

ResearcherCell and Systems BiologyUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Bryan Coburn

Researcher

Cell and Systems Biology

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
40 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (5 CIHR), most recently in 2022.
Supervised 2 trainees who won CIHR awards, most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

571

Citations

h-index

108

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Microbiome Antimicrobial Resistance Clinical Trial Infection Female Genital Tract Foreskin Hiv Susceptibility International Health

Latest papers

The baseline vaginal immune milieu is an important determinant of the inflammatory response induced by penile-vaginal sex.
Clinical immunology (Orlando, Fla.) · 2026
Transient gingival inflammation is associated with epithelial dysfunction and systemic immune activation beyond clinical improvement.
Journal of periodontology · 2026
Vaginal microbe-binding antibody interactions with a Lactobacillus crispatus live biotherapeutic following treatment for bacterial vaginosis.
Microbiology spectrum · 2026

All 75 publications

Latest funding

BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections
CIHR · 2025 · Co-investigator
$1,908,674
Defining and disrupting genital microbiome transfer to prevent HIV acquisition and improve genital health.
CIHR · 2024 · Co-investigator
$925,652
Optimizing The Vaginal Microbiome In African, Caribbean And Other Black (ACB) Women From Toronto, Canada: Defining Clinical Endpoints And Community Priorities
CIHR · 2024 · Co-investigator
$100,000

All 22 grants and awards

75 publications.

The baseline vaginal immune milieu is an important determinant of the inflammatory response induced by penile-vaginal sex.

Tsang J, Mohammadi A, Bagherichimeh S, Choi Y, Fazel A, Tevlin E, Huibner S, Good SV, Tharao W, Coburn B, Kaul R

Clinical immunology (Orlando, Fla.)2026

DOI: 10.1016/j.clim.2025.110615 PMID: 42301730

Transient gingival inflammation is associated with epithelial dysfunction and systemic immune activation beyond clinical improvement.

Elebyary O, Liu R, Tsang J, Sun C, Coburn B, Glogauer M

Journal of periodontology2026

DOI: 10.1002/jper.70028 PMID: 42125961

Vaginal microbe-binding antibody interactions with a Lactobacillus crispatus live biotherapeutic following treatment for bacterial vaginosis.

Liu R, Armstrong E, Hemmerling A, Miller S, Huibner S, Lagenaur L, Parks TP, Cohen CR, Coburn B, Kaul R

Microbiology spectrum2026

DOI: 10.1128/spectrum.03983-25 PMID: 42678149

Lung microbiome quantification and bacterial density as prognostic markers in lung transplantation.

Santilli J, Reguera-Nuñez E, Armstrong E, Wijesinha Z, Levy L, Schneeberger PHH, Ramendra R, Zhang CYK, Huszti E, Martinu T, Coburn B

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2026Senior author

DOI: 10.1016/j.healun.2025.12.017 PMID: 41453696

Prediction of genetic relatedness of Escherichia coli using neighbor typing: a tool for rapid outbreak detection.

Carroll AC, Mortimer L, Ghosh H, Reuter S, Grundmann H, Brinda K, Hanage WP, Li A, Paterson A, Purssell A, Rooney AM, Yee NR, Coburn B, Able-Thomas S, Antonio M, McGeer A, MacFadden DR

Antimicrobial agents and chemotherapy2026

DOI: 10.1128/aac.01071-25 PMID: 41586495

Initial Vancomycin Taper for the Prevention of Recurrent Clostridioides difficile Infection

McDonald EG, Butler-Laporte G, Brophy JM, Elsayed S, Frenette C, Huseen I, Loo VG, Moran K, Coburn B, Hota SS

JAMA Network Open20268 citations

DOI: 10.1001/jamanetworkopen.2025.60495

Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study

Brown KA, Coburn B, Hernandez A, Langford BJ, Leung V, MacFadden D, Rooney AM, Schwartz KL, Daneman N

Journal of Infectious Diseases20263 citations

DOI: 10.1093/infdis/jiag001

Association of anti-anaerobic antibiotics with mortality and the gut microbiome: a sub-study of the BALANCE randomized clinical trial

Armstrong E, Pinto R, Kulikova M, Yee NR, Rishu A, Muscedere J, Sibley S, Maslove DM, Boyd JG, Evans GA

Clinical Infectious Diseases2026Senior author

DOI: 10.1093/cid/ciag460

Quantitative profiling of the vaginal microbiota improves resolution of the microbiota-immune axis.

Armstrong E, Liu R, Pollock J, Huibner S, Udayakumar S, Irungu E, Ngurukiri P, Muthoga P, Adhiambo W, Yegorov S, Kimani J, Beattie T, Coburn B, Kaul R

Microbiome2025

DOI: 10.1186/s40168-025-02039-4 PMID: 39905573

Gut microbiome and healthy aging in HIV: data from the correlates of healthy aging in geriatric HIV (CHANGE HIV) cohort.

Armstrong E, Seo E, Boyachuk B, Loutfy M, Smith G, Falutz JM, Klein M, Coburn B, Walmsley S, Zhabokritsky A, CHANGE HIV study team

AIDS (London, England)2025

DOI: 10.1097/qad.0000000000004412 PMID: 41284313

BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections

Co-investigatorCIHR2025Project Grant

Principal investigators: Daneman, Nick; Fowler, Robert A; Johnstone, Jennie; Lee, Todd C; MacFadden, Derek R; McDonald, Emily G; Ong, Sean W; Pinto, Ruxandra; Rogers, Benjamin A

Keywords: Adaptive Platform Trial; Antibiotic De-Escalation; Antibiotic Duration; Antibiotic Oral Switch; Antimicrobial Resistance; Bloodstream Infection; Central Venous Catheter Infection; Gram Negative Bacteremia; Randomized Clinical Trial

$1,908,674

Defining and disrupting genital microbiome transfer to prevent HIV acquisition and improve genital health.

Co-investigatorCIHR2024Project Grant

Principal investigators: Kaul, Rupert

Keywords: Antibiotics; Genital Microbiome; Global Health; Hiv Susceptibility; In Vitro Models; Penile-Vaginal Sex

$925,652

Optimizing The Vaginal Microbiome In African, Caribbean And Other Black (ACB) Women From Toronto, Canada: Defining Clinical Endpoints And Community Priorities

Co-investigatorCIHR2024Project Grant - Priority Announcement: HIV/AIDS and STBBI

Principal investigators: Massaquoi, Notisha

Keywords: African, Carribbean, Black ( Acb); Bacterial Vaginosis; Gender; Health Disparities; Hiv; Probiotics; Vaginal Microbiome

$100,000

Targeting the gut microbiome to reduce antimicrobial resistance

SupervisorCIHR2024CIHR Fellowship

Principal investigators: Armstrong, Eric

Keywords: Adaptive Platform Trial; Antibiotic Stewardship; Antibiotics; Antimicrobial Resistance; Bacteremia; Clinical Trial; Fecal Microbiota Transplantation; Gastrointestinal Tract; Infectious Diseases; Microbiome

$210,000

Optimizing the vaginal microbiome In African, Caribbean and other Black women from Toronto, Canada: defining clinical endpoints and community priorities

Co-investigatorCIHR2023Proect Grant - PA: Intersectionality in Sex, Gender and Health Research

Principal investigators: Kaul, Rupert

Keywords: African, Caribbean And Other Black Communities; Bacterial Vaginosis; Inflammation; Probiotic; Reproductive Health; Vaginal Microbiome

$100,000

Disentangling Acute Respiratory Distress Syndrome (ARDS) Heterogeneity via the Gut-Lung Axis: Predictive Biomarkers and Therapeutic Insights

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Kain, Taylor

Keywords: Acute Hypoxemic Respiratory Failure; Acute Respiratory Distress Syndrome; Bile Acid Metabolism; Critical Illness; Endothelial Activation; Gut Epithelial Integrity; Inflammation; Microbiome; Sepsis; Short Chain Fatty Acid Production

$105,000

BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Daneman, Nick; Murthy, Srinivas; Yamamura, Deborah L; Fowler, Robert A; Johnstone, Jennie; Lee, Todd C; MacFadden, Derek R; McDonald, Emily G; Paterson, David L; Rogers, Benjamin A; Yahav, Dafna

Keywords: Adaptive Platform Trial; Antibiotic De-Escalation; Antibiotic Step-Down; Antimicrobial Resistance; Bloodstream Infection; Central Venous Catheter Infection; Gram Negative Bacteremia; Randomized Controlled Trial

$729,947

Antimicrobial Resistant Organism Decolonization After Microbiome Perturbation (ARO-DECAMP)

Nominated PICIHR2022Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Coburn, Bryan A; Hota, Susy S; Kain, Kevin C; MacFadden, Derek R; Walmsley, Sharon L

Keywords: Antimicrobial Resistance; Clinical Trial; Infection; Microbiome

$173,934

Antimicrobial Resistant Organism Decolonization After Microbiome Perturbation (ARO-DECAMP)

Nominated PICIHR2022Operating Grant: Clinical Trials Projects

Principal investigators: Coburn, Bryan A; Hota, Susy S; Kain, Kevin C; MacFadden, Derek R; Walmsley, Sharon L

Keywords: Antimicrobial Resistance; Clinical Trial; Infection; Microbiome

$695,739

BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections

Co-investigatorCIHR2022Operating Grant: Clinical Trials Projects

$2,919,785

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Bryan Coburn

Research

Latest papers

Latest funding

The baseline vaginal immune milieu is an important determinant of the inflammatory response induced by penile-vaginal sex.

Transient gingival inflammation is associated with epithelial dysfunction and systemic immune activation beyond clinical improvement.

Vaginal microbe-binding antibody interactions with a Lactobacillus crispatus live biotherapeutic following treatment for bacterial vaginosis.

Lung microbiome quantification and bacterial density as prognostic markers in lung transplantation.

Prediction of genetic relatedness of Escherichia coli using neighbor typing: a tool for rapid outbreak detection.

Initial Vancomycin Taper for the Prevention of Recurrent Clostridioides difficile Infection

Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study

Association of anti-anaerobic antibiotics with mortality and the gut microbiome: a sub-study of the BALANCE randomized clinical trial

Quantitative profiling of the vaginal microbiota improves resolution of the microbiota-immune axis.

Gut microbiome and healthy aging in HIV: data from the correlates of healthy aging in geriatric HIV (CHANGE HIV) cohort.

Frequent collaborators

Rupert Kaul

Anna Spreafico

Nick Daneman

Allison McGeer

Emma Allen-Vercoe

John Muscedere

Sylvain Lother

Ruxandra Pinto

Susan Poutanen

Michael Detsky

Jennifer Tsang

Erick Duan

Aidan Findlater

Francois Lamontagne

George Tomlinson

Guillaume Butler-Laporte

Aleksandra Leligdowicz

Derek MacFadden

Peter Daley

Leanne Mortimer

Andrew Purssell

Ranjani Somayaji

Lisa Avery

Andrzej Chruscinski

Anand Kumar

Stephanie Sibley

Tereza Martinu

Andrew Morris

John Marshall

Deborah Cook

François Lauzier

Peter Dodek

Wei Xu

Michael Glogauer

Lauralyn McIntyre

Andrew Morris

Marina Klein

Herbert Gaisano

Robert Fowler

Jianhong Wu