James Duffin, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Discordant ventilatory and efferent sympathetic responsiveness to peripheral and central chemoreflex stimulation in heart failure with reduced ejection fraction.
European journal of heart failure · 2026
Apnea Testing for Brain Death/Death by Neurologic Criteria in Adults: A Prospective Multicenter Observational Study Assessing the Relationship Between Methodology, Safety, and Duration
Critical Care Explorations · 2026
Cerebrovascular reactivity differences in healthy cerebral gray and white matter.
Magnetic resonance in medicine · 2025

All 106 publications

Latest funding

Peripheral and central chemoreceptor reflex regulation of sympathetic activity in heart failure patients with and without sleep apnea
CIHR · 2018 · Co-investigator
$359,550

All 1 grants and awards

106 publications.

01

Discordant ventilatory and efferent sympathetic responsiveness to peripheral and central chemoreflex stimulation in heart failure with reduced ejection fraction.

Keir DA, Nardone M, Guluzade NA, Keys E, Badrov MB, Duffin J, Floras JS

European journal of heart failure2026

DOI: 10.1093/ejhf/xuag127 PMID: 42048135

02

Apnea Testing for Brain Death/Death by Neurologic Criteria in Adults: A Prospective Multicenter Observational Study Assessing the Relationship Between Methodology, Safety, and Duration

Cuninghame S, Basmaji J, Duffin J, Healey A, Paltser B, Snyder-Salehi M, Yoshiki A, Boyd JG, Hartwick M, Soliman K

Critical Care Explorations20261 citations

DOI: 10.1097/cce.0000000000001437

03

Cerebrovascular reactivity differences in healthy cerebral gray and white matter.

Levine HT, Poublanc J, Sayin ES, Duffin J, Sobczyk O, Fisher JA, Mikulis DJ

Magnetic resonance in medicine2025

DOI: 10.1002/mrm.30481 PMID: 40189818

04

MRI-Based Classification of Cerebral Hemodynamic Failure With Resting Perfusion Metrics and Cerebrovascular Reactivity.

Sayin ES, Duffin J, Poublanc J, Fisher JA, Mikulis DJ, Sobczyk O

Stroke2025

DOI: 10.1161/strokeaha.125.050978 PMID: 40772322

05

Editorial: Measuring resting cerebral perfusion using magnetic resonance imaging (MRI).

Duffin J, Bhogal AA

Frontiers in physiology2024First author

DOI: 10.3389/fphys.2024.1447417 PMID: 39040081

06

Variability of Resting Carbon Dioxide Tension in Patients with Intracranial Steno-occlusive Disease.

Plitman E, Venkatraghavan L, Agrawal S, Raghavan V, Chowdhury T, Sobczyk O, Sayin ES, Poublanc J, Duffin J, Mikulis D, Fisher J

Asian journal of neurosurgery2024

DOI: 10.1055/s-0044-1786699 PMID: 38974441

07

Transient deoxyhemoglobin formation as a contrast for perfusion MRI studies in patients with brain tumors: a feasibility study.

Stumpo V, Sayin ES, Bellomo J, Sobczyk O, van Niftrik CHB, Sebök M, Weller M, Regli L, Kulcsár Z, Pangalu A, Bink A, Duffin J, Mikulis DD, Fisher JA, Fierstra J

Frontiers in physiology2024

DOI: 10.3389/fphys.2024.1238533 PMID: 38725571

08

Brain Stress Test for Assessing Risk for Hemodynamic Stroke.

Venkatraghavan L, Rosen C, McKetton L, Poublanc J, Sobczyk O, Duffin J, Tymianski M, Fisher JA, Mikulis DJ

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2024

DOI: 10.1017/cjn.2023.3 PMID: 36624923

09

Excess ventilation and chemosensitivity in patients with inefficient ventilation and chronic coronary syndrome or heart failure: a case-control study.

Eser P, Käesermann D, Calamai P, Kalberer A, Stütz L, Huber S, Duffin J, Wilhelm M

Frontiers in physiology2024

DOI: 10.3389/fphys.2024.1509421 PMID: 39911179

10

Assessment of Cerebrovascular Reactivity Using CO2-BOLD MRI: A 15-Year, Single Center Experience.

Raghavan V, Sobczyk O, Sayin ES, Poublanc J, Skanda A, Duffin J, Venkatraghavan L, Fisher JA, Mikulis DJ

Journal of magnetic resonance imaging : JMRI2024

DOI: 10.1002/jmri.29176 PMID: 38135486

Peripheral and central chemoreceptor reflex regulation of sympathetic activity in heart failure patients with and without sleep apnea

Co-investigatorCIHR2018Project Grant

Principal investigators: Floras, John S

Keywords: Autonomic Reflexes; Central Chemoreceptor Reflexes; Heart Failure; Human Research; Peripheral Chemoreceptor Reflexes; Sleep Apnea

$359,550

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Department of Physiology
Medical Imaging
Biomedical Engineering
Anesthesiology
Department of Anesthesiology and Pain Medicine
Cell and Systems Biology
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Greg Wells

Biomedical Engineering

6 shared papers, latest 2016

David Mikulis

Medical Imaging

6 shared papers, latest 2024

Marat Slessarev

Anesthesiology

5 shared papers, latest 2026

Joseph Fisher

Department of Anesthesiology and Pain Medicine

4 shared papers, latest 2024

John Peever

Cell and Systems Biology

3 shared papers, latest 2010

Melanie Cohn

Neuropsychology

2 shared papers, latest 2020

Kamil Uludag

Department of Medical Biophysics

2 shared papers, latest 2023

Karim Soliman

Critical Care Medicine

1 shared papers, latest 2026

Mark Bayley

Physical Therapy

1 shared papers, latest 2021

Marcin Wasowicz

Obstetrics and Gynecology

1 shared papers, latest 2012

Jelena Lukovic

Radiation Oncology

1 shared papers, latest 2013

Andrew Healey

Medicine

1 shared papers, latest 2026

Write to this professor

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Applying for

Paper to mention

Subject: Prospective PhD student Dear Professor Duffin, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Discordant ventilatory and efferent sympathetic responsiveness to peripheral and central chemoreflex stimulation in heart failure with reduced ejection fraction." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

James Duffin

Research

Latest papers

Latest funding

Discordant ventilatory and efferent sympathetic responsiveness to peripheral and central chemoreflex stimulation in heart failure with reduced ejection fraction.

Apnea Testing for Brain Death/Death by Neurologic Criteria in Adults: A Prospective Multicenter Observational Study Assessing the Relationship Between Methodology, Safety, and Duration

Cerebrovascular reactivity differences in healthy cerebral gray and white matter.

MRI-Based Classification of Cerebral Hemodynamic Failure With Resting Perfusion Metrics and Cerebrovascular Reactivity.

Editorial: Measuring resting cerebral perfusion using magnetic resonance imaging (MRI).

Variability of Resting Carbon Dioxide Tension in Patients with Intracranial Steno-occlusive Disease.

Transient deoxyhemoglobin formation as a contrast for perfusion MRI studies in patients with brain tumors: a feasibility study.

Brain Stress Test for Assessing Risk for Hemodynamic Stroke.

Excess ventilation and chemosensitivity in patients with inefficient ventilation and chronic coronary syndrome or heart failure: a case-control study.

Assessment of Cerebrovascular Reactivity Using CO2-BOLD MRI: A 15-Year, Single Center Experience.

Peripheral and central chemoreceptor reflex regulation of sympathetic activity in heart failure patients with and without sleep apnea

Frequent collaborators

Greg Wells

David Mikulis

Marat Slessarev

Joseph Fisher

John Peever

Andrea Kassner

Marat Slessarev

Melanie Cohn

Michael Tymianski

Kamil Uludag

Ira Jacobs

Scott Thomas

Karim Soliman

Claudio Martin

Greg Wells

Mark Bayley

Marcin Wasowicz

Gaspard Montandon

Jelena Lukovic

Irene Telias

Andrew Healey