Faculty profile

John Sled

ResearcherMouse Imaging CentreUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

John Sled

Researcher

Mouse Imaging Centre

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
5 publications in the last five years, latest in 2026.
Principal investigator on 16 research grants (15 CIHR, 1 NSERC), most recently in 2023.
Supervised 2 trainees who won CIHR awards, most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Magnetic Resonance Imaging Mouse Model Biophysical Modelling Electrophysiology Blood Flow Mouse Models Two-Photon Fluorescence Microscopy Congenital Heart Disease

Latest papers

Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Perinatal hyperandrogenization and immune activation in rodents model subtypes of autism.
Translational psychiatry · 2026
Stable neuronal representations to repeated stimulation underlie cognitive resilience in Alzheimer's disease pathology.
bioRxiv : the preprint server for biology · 2025

All 8 publications

Latest funding

Mouse MRI to discover genetic modifiers in autism
CIHR · 2026 · Co-investigator
$1,296,677
Dolutegravir, impaired vascular remodelling, and hypertesion in pregnancy.
CIHR · 2024 · Co-investigator
$1,235,475
Building a Canadian Research Agenda for Children HIV-Exposed Uninfected
CIHR · 2024 · Co-investigator
$20,000

All 37 grants and awards

8 publications.

Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology.

Chen K, Pineau E, Koletar M, Trevisiol A, He JS, Hill M, Goubran M, Sled J, McLaurin J, Stefanovic B

Alzheimer's & dementia : the journal of the Alzheimer's Association2026

DOI: 10.1002/alz.71570 PMID: 42252511

Perinatal hyperandrogenization and immune activation in rodents model subtypes of autism.

Burke FF, Randell AM, Sparkes KM, Salia S, Hinks M, Martin Y, Porter Z, Hynes C, Maekawa AS, Sled J, Wilson DR, Kaushik DK, Kakumani PK, Walling SG, Cahill LS, Swift-Gallant A

Translational psychiatry2026

DOI: 10.1038/s41398-026-03821-0 PMID: 41611658

Stable neuronal representations to repeated stimulation underlie cognitive resilience in Alzheimer's disease pathology.

Chen K, Pineau E, Koletar M, Trevisiol A, He JS, Hill M, Goubran M, Sled J, McLaurin J, Stefanovic B

bioRxiv : the preprint server for biology2025

DOI: 10.64898/2025.12.05.692431 PMID: 41427410

Acid sphingomyelinase is a gatekeeper of placental labyrinthine architecture and function.

Rovic I, Szelag K, Li H, McQuaid R, Sugin S, Wu Q, Theodora N, Sled J, Jurisicova A

Development (Cambridge, England)2025

DOI: 10.1242/dev.204425 PMID: 40888736

Beyond genomic studies of congenital heart defects through systematic modelling and phenotyping.

Henderson DJ, Alqahtani A, Chaudhry B, Cook A, Eley L, Houyel L, Hughes M, Keavney B, de la Pompa JL, Sled J, Spielmann N, Teboul L, Zaffran S, Mill P, Liu KJ

Disease models & mechanisms2024

DOI: 10.1242/dmm.050913 PMID: 39575509

Simulations of blood as a suspension predicts a depth dependent hematocrit in the circulation throughout the cerebral cortex.

Hartung G, Vesel C, Morley R, Alaraj A, Sled J, Kleinfeld D, Linninger A

PLoS computational biology2018

DOI: 10.1371/journal.pcbi.1006549 PMID: 30452440

IFPA meeting 2016 workshop report II: Placental imaging, placenta and development of other organs, sexual dimorphism in placental function and trophoblast cell lines.

Adibi J, Burton GJ, Clifton V, Collins S, Frias AE, Gierman L, Grigsby P, Jones H, Lee C, Maloyan A, Markert UR, Morales-Prieto DM, Murthi P, Myatt L, Pollheimer J, Roberts V, Robinson W, Salafia C, Schabel M, Shah D, Sled J, Vaillancourt C, Weber M, O'Tierney-Ginn PF

Placenta2017

DOI: 10.1016/j.placenta.2017.02.021 PMID: 28284454

Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria.

Conroy AL, Silver KL, Zhong K, Rennie M, Ward P, Sarma JV, Molyneux ME, Sled J, Fletcher JF, Rogerson S, Kain KC

Cell host & microbe2013

DOI: 10.1016/j.chom.2013.01.010 PMID: 23414761

Mouse MRI to discover genetic modifiers in autism

Co-investigatorCIHR2026Project Grant

Principal investigators: Nieman, Brian J

Keywords: Autism Spectrum Disorder; Brain Health; Genetics; Mouse Models; Neurodevelopmental Disorders; Neuroimaging; Systems Genetics

$1,296,677

Dolutegravir, impaired vascular remodelling, and hypertesion in pregnancy.

Co-investigatorCIHR2024Project Grant

Principal investigators: Serghides, Lena

Keywords: Heart; Hiv Antiretroviral Therapy; Hypertension; Mmp; Placenta; Pregnancy; Vascular Stability; Zinc

$1,235,475

Building a Canadian Research Agenda for Children HIV-Exposed Uninfected

Co-investigatorCIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Serghides, Lena; Brophy, Jason C

Keywords: Children Hiv Exposed Uninfected; Hiv Antiretrovirals; Metabolic Health; Neurodevelopment; Research Priorities

$20,000

Advanced Fetal MRI Methods to Evaluate Prenatal Organ Development and Predict Postnatal Outcome in Congenital Heart Disease

Co-investigatorCIHR2023Project Grant

Principal investigators: Macgowan, Christopher K

Keywords: Blood Flow; Blood Oxygenation; Congenital Heart Disease; Fetal Imaging; Magnetic Resonance Imaging; Medical Biophysics; Organ Development; Postnatal Outcomes; Pregnancy

$1,048,050

Expanding the KIND study planning meeting

Co-investigatorCIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Serghides, Lena

Keywords: Autism; Children Who Are Hiv Exposed But Uninfected; Hiv; Hiv Antiretrovirals; Neurodevelopment; Puberty

$20,000

Dolutegravir, impaired vascular remodelling, and hypertesion in pregnancy.

Co-investigatorCIHR2023Project Grant - Priority Announcement: HIV/AIDS and STBBI

Principal investigators: Serghides, Lena

Keywords: Angiogenic; Edema; Hiv Antiretroviral Therapy; Hypertension; Placenta; Pregnancy; Vascular Stability

$100,000

Imaging metrics of neuronal stochasticity and brain resilience

Principal investigatorCIHR2023Project Grant

Principal investigators: Stefanovic, Bojana; Mclaurin, Joanne; Sled, John G

Keywords: Alzheimer'S Disease; Electrophysiology; Magnetic Resonance Imaging; Two-Photon Fluorescence Microscopy

$975,375

Promoting normal brain development in fetuses affected by hypoplastic left heart syndrome

Nominated PICIHR2023Project Grant

Principal investigators: Sled, John G

Keywords: Cerebral Blood Flow; Congenital Heart Disease; Diagnostic Ultrasound; Fetal Brain Development; Hypoplastic Left Heart Syndrome; Magnetic Resonance Imaging; Mouse Model; Physiology

$864,450

Placenta-Heart Axis: The contribution of isolated flow defects in the placenta and heart

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Debebe, Sarah

Keywords: Hypoplastic Left Heart Syndrome; Maternal Vascular Malperfusion; Placental Insufficiency; Ultrasound-Guided Microinjections

$105,000

Establishing the genetic and cellular mechanisms that control growth of the fetal left heart

Nominated PICIHR2022Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Sled, John G; Scott, Ian C

Keywords: Comparative Genomics; Congenital Heart Disease; Heart Growth; Hypoplastic Left Heart Syndrome; Imaging; Model Organism; Transcriptomics

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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John Sled

Research

Latest papers

Latest funding

Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology.

Perinatal hyperandrogenization and immune activation in rodents model subtypes of autism.

Stable neuronal representations to repeated stimulation underlie cognitive resilience in Alzheimer's disease pathology.

Acid sphingomyelinase is a gatekeeper of placental labyrinthine architecture and function.

Beyond genomic studies of congenital heart defects through systematic modelling and phenotyping.

Simulations of blood as a suspension predicts a depth dependent hematocrit in the circulation throughout the cerebral cortex.

IFPA meeting 2016 workshop report II: Placental imaging, placenta and development of other organs, sexual dimorphism in placental function and trophoblast cell lines.

Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria.

Mouse MRI to discover genetic modifiers in autism

Dolutegravir, impaired vascular remodelling, and hypertesion in pregnancy.

Building a Canadian Research Agenda for Children HIV-Exposed Uninfected

Advanced Fetal MRI Methods to Evaluate Prenatal Organ Development and Predict Postnatal Outcome in Congenital Heart Disease

Expanding the KIND study planning meeting

Dolutegravir, impaired vascular remodelling, and hypertesion in pregnancy.

Imaging metrics of neuronal stochasticity and brain resilience

Promoting normal brain development in fetuses affected by hypoplastic left heart syndrome

Placenta-Heart Axis: The contribution of isolated flow defects in the placenta and heart

Establishing the genetic and cellular mechanisms that control growth of the fetal left heart

Frequent collaborators

Joanne McLaurin

Maged Goubran

Bojana Stefanovic

Wendy Robinson

Ashlyn Swift-Gallant

Andrea Jurisicova