Faculty profile

Joanne McLaurin

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ProfessorDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto

Joanne McLaurin

Professor

Department of Laboratory Medicine and Pathobiology

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Canada Research Chair in Alzheimer Disease Therapeutics

ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
20 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 19 research grants (14 CIHR, 5 NSERC), most recently in 2025.
Supervised 3 trainees who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

181

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Education

Ph.D. in Clinical Biochemistry
M.Sc. in Clinical Biochemistry
B.Sc. in Chemistry

Profiles and links

University Profile Search on Google Scholar iDORCID

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Alzheimer'S Disease Dementia Gene Therapy Magnetic Resonance Imaging Diagnosis Prevention Brain Injury Derisking

Latest papers

Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
A deep learning pipeline for mapping in situ network-level neurovascular coupling in multi-photon fluorescence microscopy.
eLife · 2026
Quantitative profiling of whole-brain connectomes at single-axon resolution using deep learning and high-resolution light sheet microscopy.
bioRxiv : the preprint server for biology · 2025

All 89 publications

Latest funding

Precision Cellular Reprogramming for Functional Brain Renewal
CIHR · 2025 · Nominated PI
$1,530,000
Converting astrocytes into neurons therapeutically reshapes cell-cell communication in Alzheimer's disease
CIHR · 2025 · Supervisor
$120,000
Imaging metrics of neuronal stochasticity and brain resilience
CIHR · 2023 · Principal investigator
$975,375

All 30 grants and awards

89 publications.

Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology.

Chen K, Pineau E, Koletar M, Trevisiol A, He JS, Hill M, Goubran M, Sled J, McLaurin J, Stefanovic B

Alzheimer's & dementia : the journal of the Alzheimer's Association2026

DOI: 10.1002/alz.71570 PMID: 42252511

A deep learning pipeline for mapping in situ network-level neurovascular coupling in multi-photon fluorescence microscopy.

Rozak MW, Mester JR, Attarpour A, Dorr A, Patel S, Koletar M, Hill ME, McLaurin J, Goubran M, Stefanovic B

eLife2026

DOI: 10.7554/elife.95525 PMID: 41873945

Quantitative profiling of whole-brain connectomes at single-axon resolution using deep learning and high-resolution light sheet microscopy.

Attarpour A, Raffiee M, Xu T, Osmann J, Patel S, Yu F, Au B, Clappison A, Biparva M, Zhu R, Crow A, Gharagoz BE, Rozak M, Aubert I, McLaurin J, Deisseroth K, Stefanovic B, Goubran M

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2025.11.14.688340 PMID: 41292859

Stepwise connectivity of the entorhinal cortex along connectomic gradients in Alzheimer's disease.

Tan JXM, Kang MS, Yeh YH, Bezgin G, Lussier FZ, Hong SJ, Isen J, Rahmouni N, Vitali P, Montembeault M, Klostranec JM, Macedo AC, Chan T, McLaurin J, Swardfager W, Bernhardt BC, Stefanovic B, Soucy JP, Gauthier S, Black SE, Rosa-Neto P, Ottoy J, Goubran M

Brain communications2025

DOI: 10.1093/braincomms/fcaf399 PMID: 41194888

High-caloric intake rescues early symptomatic AD-induced hippocampal neurovascular coupling deficits.

Almanza DLV, Trevisiol A, Koletar MM, Lai AY, Ribeiro JA, Hill ME, Stanisz GJ, McLaurin J, Stefanovic B

Alzheimer's & dementia : the journal of the Alzheimer's Association2025

DOI: 10.1002/alz.70708 PMID: 41017546

Deep brain stimulation-induced normalization of hippocampal synchrony in a transgenic rat model of Alzheimer's disease.

Trevisiol A, Beckett T, Vila MB, Hill M, McLaurin J, Stefanovic B

Theranostics2025

DOI: 10.7150/thno.110292 PMID: 41041062

A deep learning pipeline for three-dimensional brain-wide mapping of local neuronal ensembles in teravoxel light-sheet microscopy.

Attarpour A, Osmann J, Rinaldi A, Qi T, Lal N, Patel S, Rozak M, Yu F, Cho N, Squair J, McLaurin J, Raffiee M, Deisseroth K, Courtine G, Ye L, Stefanovic B, Goubran M

Nature methods2025

DOI: 10.1038/s41592-024-02583-1 PMID: 39870865

Examining the NEUROG2 lineage and associated gene expression in human cortical organoids.

Vasan L, Chinchalongporn V, Saleh F, Zinyk D, Ke C, Suresh H, Ghazale H, Belfiore L, Touahri Y, Oproescu AM, Patel S, Rozak M, Amemiya Y, Han S, Moffat A, Black SE, McLaurin J, Near J, Seth A, Goubran M, Reiner O, Gillis J, Wang C, Okawa S, Schuurmans C

Development (Cambridge, England)2025

DOI: 10.1242/dev.202703 PMID: 39680368

Unveiling the structural proteome of an Alzheimer's disease rat brain model.

Samani EK, Hasan SMN, Waas M, Keszei AFA, Xu X, Heydari M, Hill ME, McLaurin J, Kislinger T, Mazhab-Jafari MT

Structure (London, England : 1993)2025

DOI: 10.1016/j.str.2024.11.004 PMID: 39615488

Stable neuronal representations to repeated stimulation underlie cognitive resilience in Alzheimer's disease pathology.

Chen K, Pineau E, Koletar M, Trevisiol A, He JS, Hill M, Goubran M, Sled J, McLaurin J, Stefanovic B

bioRxiv : the preprint server for biology2025

DOI: 10.64898/2025.12.05.692431 PMID: 41427410

Precision Cellular Reprogramming for Functional Brain Renewal

Nominated PICIHR2025Project Grant

Principal investigators: Mclaurin, Joanne

Keywords: Brain Injury; Derisking; Gene Therapy; Manufactoring; Neurodegeneration; Neurotrauma; Translation

$1,530,000

Converting astrocytes into neurons therapeutically reshapes cell-cell communication in Alzheimer's disease

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Tahmasian, Nareh

Keywords: Alzheimer'S Disease; Cellular Reprogramming; Neurodegeneration; Neuroinflammation; Regenerative Medicine; Single-Cell Transcriptomics; Spatial Transcriptomics

$120,000

Imaging metrics of neuronal stochasticity and brain resilience

Principal investigatorCIHR2023Project Grant

Principal investigators: Stefanovic, Bojana; Mclaurin, Joanne; Sled, John G

Keywords: Alzheimer'S Disease; Electrophysiology; Magnetic Resonance Imaging; Two-Photon Fluorescence Microscopy

$975,375

Canadian Consortium on Neurodegeneration in Aging: Application for Phase III CCNA Operations Centre

Principal investigatorCIHR2023Canadian Consortium on Neurodegeneration in Aging

Principal investigators: Chertkow, Howard M; Anderson, Nicole D; Andrew, Melissa K; Badhwar, Amanpreet; Belleville, Sylvie N; Bethell, Jennifer M; Bhangu, Jaspreet S; Black, Sandra E; Borrie, Michael J; Brewster, Paul W; Camicioli, J. Richard M; Crowshoe, Lynden L; Darvesh, Sultan; DeMarco, Mari; Dixon, Roger A; Duchesne, Simon; Einstein, Gillian; Evans, Alan C; Feldman, Howard; Fisk, John D; Geddes, Maiya R; Lim, Andrew S; Masellis, Mario; McAiney, Carrie A; Mclaurin, Joanne; Montero Odasso, Manuel M; Nygaard, Haakon B; O'Connell, Megan E; Phillips, Natalie A; Rajah, Maria N; Roach, Pamela Marie; Robillard, Julie; Rockwood, Kenneth; Smith, Eric E; Villeneuve, Sylvia C; Waldron, Ingrid R; Walker, Jennifer

Keywords: Biomarkers; Brain Imaging; Cognition; Dementia; Diagnosis; Edi; Indigenous Cognitive Health; Knowledge Mobilization; Prevention; Risk Factors

$20,555,200

Planning for patient engagement in biomedical research

Principal investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Bethell, Jennifer M; Mclaurin, Joanne

Keywords: Brain; Dementia; Gene Therapy; Neurodegenerative Diseases; Neurons; Patient Engagement; Transcription Factors

$10,000

A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders

Co-investigatorSSHRC2022New Frontiers in Research Fund - Transformation

Principal investigators: Schuurmans, Carol

Keywords: neurodegenerative disease,; Alzheimer's disease; direct neuronal reprogramming; transcription factors; gene regulatory networks ; computer-guided design; nanoparticles; epigenomics ; neurological disorders; self-amplifying RNA; bacteriophage; astrocytes; stroke; epilepsy; focused ultrasound

$8,000,000

Rescue of entorhinal-hippocampal neuronal network dysfunction in Alzheimer's disease

Principal investigatorCIHR2021Project Grant

Principal investigators: Goubran, Maged; Mclaurin, Joanne; Stefanovic, Bojana

Keywords: Alzheimer'S Disease; Cognitive Deficits; Combinatory Therapy; Computational Neuroscience; Functional Connectivity; Network Dysfunction; Structural Connectivity; Tau; Tissue Clearing

$905,150

Health Research Training to Address Vascular Contributions to Cognitive Decline: the Vascular Training (VAST) Platform

Co-investigatorCIHR2021Tr. Grant: Health Research Training Platform - Vascular Cognitive Impairment

Principal investigators: Smith, Eric E; Badhwar, Amanpreet; Mazerolle, Erin L; Stefanovic, Bojana

Keywords: Vascular Cognitive Impairment

$2,380,292

Rescuing Neurovascular Network Function with Transcranial Neuromodulation

Co-investigatorCIHR2020Project Grant

Principal investigators: Stefanovic, Bojana; Sled, John G

Keywords: Biophysical Modelling; Electrophysiology; Magnetic Resonance Imaging; Neurovascular Coupling; Stroke; Two-Photon Fluorescence Microscopy

$849,150

Long-term effects of mild traumatic brain injury through premature cellular senescence

Principal investigatorCIHR2019Project Grant

Principal investigators: Hazrati, Lili-Naz; Mclaurin, Joanne; Stefanovic, Bojana; Wells, Peter G

Keywords: Brca1; Dna Damage; Dna Repair; Inflammation; Mild Traumatic Brain Injury; Ovariectomy; Post-Concussive Syndrome; Senescence; Senolytic

$1,067,176

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Joanne McLaurin

Research

Latest papers

Latest funding

Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology.

A deep learning pipeline for mapping in situ network-level neurovascular coupling in multi-photon fluorescence microscopy.

Quantitative profiling of whole-brain connectomes at single-axon resolution using deep learning and high-resolution light sheet microscopy.

Stepwise connectivity of the entorhinal cortex along connectomic gradients in Alzheimer's disease.

High-caloric intake rescues early symptomatic AD-induced hippocampal neurovascular coupling deficits.

Deep brain stimulation-induced normalization of hippocampal synchrony in a transgenic rat model of Alzheimer's disease.

A deep learning pipeline for three-dimensional brain-wide mapping of local neuronal ensembles in teravoxel light-sheet microscopy.

Examining the NEUROG2 lineage and associated gene expression in human cortical organoids.

Unveiling the structural proteome of an Alzheimer's disease rat brain model.

Stable neuronal representations to repeated stimulation underlie cognitive resilience in Alzheimer's disease pathology.

A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders

Frequent collaborators

Bojana Stefanovic

Isabelle Aubert

Maged Goubran

Mark Nitz

Kullervo Hynynen

Pedro Rosa-Neto

Serge Gauthier

Margaret Fahnestock

Neil Vasdev

Serge Gauthier

Dale Corbett

Lili-Naz Hazrati

Julie Ottoy

Jean-Paul Soucy

Margaret Fahnestock

Carol Schuurmans

John Sled

Peter ST GEORGE-HYSLOP

Louis Bherer

Meaghan O'Reilly

Colleen Maxwell

Gary Naglie

Ekaterina Rogaeva

John Kim

Megan O'Connell

Simon Ducharme

Shreejoy Tripathy

Neil Cashman

Debra Morgan

Howard Bergman

Nathan Herrmann

Edith Hamel

Elizabeth Finger

Andrew Lim

Ian Mackenzie

Howard Feldman

Mark Rapoport

Sandra Black

Eric Smith

Gillian Einstein