Faculty profile
Jonathan Rocheleau
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Latest papers
Oxidized Low-Density Lipoprotein Accumulation in Macrophages Impairs Lipopolysaccharide-Induced Activation of AKT2, ATP Citrate Lyase, Acetyl-Coenzyme A Production, and Inflammatory Gene H3K27 Acetylation.
ImmunoHorizons · 2024
Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1α to the Nrf2 Pathway.
Journal of immunology (Baltimore, Md. : 1950) · 2023
GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
Latest funding
- $791,776
Linking the dynamics of islet metabolism to first-phase insulin release.
CIHR · 2025 · Nominated PI
- $100,000
Linking the dynamics of islet metabolism to first-phase insulin release.
CIHR · 2024 · Nominated PI
- $120,000
Mapping cellular metabolism in tissues: multi-parameter assays combining live cell fluorescence microscopy and islet/tissue-on-a-chip.
NSERC · 2022 · Principal investigator
3 publications.
Oxidized Low-Density Lipoprotein Accumulation in Macrophages Impairs Lipopolysaccharide-Induced Activation of AKT2, ATP Citrate Lyase, Acetyl-Coenzyme A Production, and Inflammatory Gene H3K27 Acetylation.
Ting KKY, Yu P, Iyayi M, Dow R, Hyduk SJ, Floro E, Ibrahim H, Karim S, Polenz CK, Winer DA, Woo M, Rocheleau J, Jongstra-Bilen J, Cybulsky MI
Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1α to the Nrf2 Pathway.
Ting KKY, Yu P, Dow R, Floro E, Ibrahim H, Scipione CA, Hyduk SJ, Polenz CK, Zaslaver O, Karmaus PWF, Fessler MB, Röst HL, Ohh M, Tsai S, Winer DA, Woo M, Rocheleau J, Jongstra-Bilen J, Cybulsky MI
GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity.
Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Al Rijjal D, Winegarden N, Virtanen C, Orser BA, Cabrera O, Varga G, Rocheleau J, Dai FF, Wheeler MB
Linking the dynamics of islet metabolism to first-phase insulin release.
Principal investigators: Rocheleau, Jonathan V
Keywords: Atp; Glycolysis; Insulin Secretion; Islet; Islet-On-A-Chip; Live Cell Imaging; Metabolism; Nad; Nadp; Oxidative Phosphorylation
Linking the dynamics of islet metabolism to first-phase insulin release.
Principal investigators: Rocheleau, Jonathan V
Keywords: Atp; Glycolysis; Insulin Secretion; Islet; Islet-On-A-Chip; Live Cell Imaging; Metabolism; Nad; Nadp; Oxidative Phosphorylation
Mapping cellular metabolism in tissues: multi-parameter assays combining live cell fluorescence microscopy and islet/tissue-on-a-chip.
Principal investigators: Rocheleau, Jonathan
Mapping cellular metabolism in tissues: multi-parameter assays combining live cell fluorescence microscopy and islet/tissue-on-a-chip.
Principal investigators: Rocheleau, Jonathan
Determining the impact of metabolic heterogeneity on the proliferation and survival of pancreatic beta-cells.
Principal investigators: Rocheleau, Jonathan V
Keywords: Beta-Cell; Genetically Encoded Sensors; Live Cell Imaging; Metabolism; Microfluidic Devices; Nadh; Nadph; Proliferation; Survival
A high-content multicolour fluorescence anisotropy microscope to systematically assay cellular metabolism using genetically encoded sensors and machine learning.
Principal investigators: Rocheleau, Jonathan
Mapping cell metabolism in tissues: NADPH/NADP+ redox state in the regulation of cell dedifferentiation, proliferation, and survival.
Principal investigators: Rocheleau, Jonathan
Design and fabrication of a standard to align multicolour TIRF microscopes.
Principal investigators: Rocheleau, Jonathan
Advanced imaging systems for microfluidic platforms to enable the discovery and development of novel therapeutics
Principal investigators: Simmons, Craig
High-throughput screening of nanoparticle tissue penetration using a microfluidic device.
Principal investigators: Rocheleau, Jonathan
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Division of Advanced Diagnostics-Metabolism
- Medicine
- Department of Laboratory Medicine and Pathobiology
- Medical Microbiology and Immunology
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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