Michael Ohh, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Vhl Cancer Signalling Hif Hypoxia Hypoxia-Inducible Factor Oxygen-Sensing Pathway Polycythemia

Latest papers

Assessment of HIF2α mutational pathogenicity using microscale thermophoresis.
Biology methods & protocols · 2026 · senior author
Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain.
eLife · 2025 · senior author
Comparative single-cell transcriptomic profiling of patient-derived renal carcinoma cells in cellular and animal models of kidney cancer.
FEBS open bio · 2025 · senior author

All 65 publications

Latest funding

Investigating the effects of HIF-2 inhibition on a clear cell renal cell carcinoma model
CIHR · 2024 · Supervisor
$120,000
Molecular characterization of pseudohypoxic cancer syndromes
CIHR · 2023 · Nominated PI
$1,109,250
Molecular characterization of RAS GTPase
CIHR · 2019 · Nominated PI
$1,025,100

All 12 grants and awards

65 publications.

01

Assessment of HIF2α mutational pathogenicity using microscale thermophoresis.

Ferens FG, Taber CC, Eo JJ, Ohh M

Biology methods & protocols2026Senior author

DOI: 10.1093/biomethods/bpag001 PMID: 41640450

02

Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain.

Taber CC, He W, Gasmi-Seabrook GMC, Hubert M, Ferens FG, Ikura M, Lee JE, Ohh M

eLife2025Senior author

DOI: 10.7554/elife.107121 PMID: 41114716

03

Comparative single-cell transcriptomic profiling of patient-derived renal carcinoma cells in cellular and animal models of kidney cancer.

Huang R, Kee L, Gont A, Meens J, Ferens FG, Irwin MS, Ailles L, Yuzwa SA, Robinson CM, Ohh M

FEBS open bio2025Senior author

DOI: 10.1002/2211-5463.70022 PMID: 40241258

04

Glucose deprivation impairs hypoxia-inducible factor-1α synthesis.

Hubert M, Stuart S, Ohh M

Discover oncology2024Senior author

DOI: 10.1007/s12672-024-01484-1 PMID: 39466364

05

Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α.

He W, Gasmi-Seabrook GMC, Ikura M, Lee JE, Ohh M

Proceedings of the National Academy of Sciences of the United States of America2024Senior author

DOI: 10.1073/pnas.2408104121 PMID: 39231207

06

Cathepsins L and B target HIF1α for oxygen-independent proteolytic cleavage.

Stuart S, Tarade D, Ohh M

Scientific reports2024Senior author

DOI: 10.1038/s41598-024-65537-9 PMID: 38926538

07

Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome.

Ferens FG, Taber CC, Stuart S, Hubert M, Tarade D, Lee JE, Ohh M

Communications biology2024Senior author

DOI: 10.1038/s42003-024-05904-4 PMID: 38418569

08

SHP2 Inhibition with TNO155 Increases Efficacy and Overcomes Resistance of ALK Inhibitors in Neuroblastoma.

Valencia-Sama I, Kee L, Christopher G, Ohh M, Layeghifard M, Shlien A, Hayes MN, Irwin MS

Cancer research communications2023

DOI: 10.1158/2767-9764.crc-23-0234 PMID: 38032104

09

Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1α to the Nrf2 Pathway.

Ting KKY, Yu P, Dow R, Floro E, Ibrahim H, Scipione CA, Hyduk SJ, Polenz CK, Zaslaver O, Karmaus PWF, Fessler MB, Röst HL, Ohh M, Tsai S, Winer DA, Woo M, Rocheleau J, Jongstra-Bilen J, Cybulsky MI

Journal of immunology (Baltimore, Md. : 1950)2023

DOI: 10.4049/jimmunol.2300293 PMID: 37756544

10

Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmata.

Ohh M, Taber CC, Ferens FG, Tarade D

eLife2022First author

DOI: 10.7554/elife.80774 PMID: 36040300

Investigating the effects of HIF-2 inhibition on a clear cell renal cell carcinoma model

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Huang, Richard

Keywords: Cancer Therapeutics; Clear Cell Renal Cell Carcinoma; Kidney Cancer; Metastasis; Single-Cell Rna Sequencing; Von Hippel-Lindau (Vhl) Disease

$120,000

Molecular characterization of pseudohypoxic cancer syndromes

Nominated PICIHR2023Project Grant

Principal investigators: Ohh, Michael

Keywords: Cancer; Hypoxia-Inducible Factor; Oxygen-Sensing Pathway; Polycythemia; Prolylhydroxylase; Pseudohypoxic Cancer Syndromes; Von Hippel-Lindau

$1,109,250

Molecular characterization of RAS GTPase

Nominated PICIHR2019Project Grant

Principal investigators: Ohh, Michael

Keywords: Phosphorylation; Ras; Signalling

$1,025,100

Molecular characterization of VHL-HIF axis in cancer

Nominated PICIHR2018Project Grant

Principal investigators: Ohh, Michael

Keywords: Cancer Biology; Hif; Signalling; Vhl

$1,013,626

Structural Biology of Calcium-Dependent Cellular Processes in Health and Disease

Co-investigatorCIHR2016Foundation Grant

Principal investigators: Ikura, Mitsuhiko

Keywords: Calcium Signaling; Cell Adhesion; Crystallography; Ion Channel; Membrane Protein; Nmr; Protein Structure; Signal Transduction; Structural Biology

$2,235,612

Molecular characterization of EpoR regulation in cancer progression

Nominated PICIHR2014Operating Grant

Principal investigators: Ohh, Michael

Keywords: Cancer; Erythropoietin Receptor; Hypoxia; Phd; Vhl

$834,840

Molecular characterization of VHL-HIF axis

Nominated PICIHR2013Operating Grant

Principal investigators: Ohh, Michael

Keywords: Dna Methylation; E3; Hif; Hypoxia; Kidney Cancer; Vhl

$756,890

Molecular Characterization of SOCS1-Mediated Regulation of the GM-CSF Receptor

SupervisorCIHR2013Master's Award: Canada Graduate Scholarships

Principal investigators: Kommaraju, Kamya

Keywords: Gm-Csf; Jak2; Juvenile Myelomonocytic Leukemia; Socs1; Ubiquitin

$17,500

Molecular characterization of JMML

Nominated PICIHR2011Operating Grant

Principal investigators: Ohh, Michael

Keywords: Cbl; E3; Juvenile Myelomonocytic Leukaemia; Pharmacologic Inhibitor; Src; Ubiquitin

$782,020

Role of DCN1 in the regulation of the VHL tumour suppressor complex

SupervisorCIHR2011Master's Award: Canada Graduate Scholarships

Principal investigators: Greer, Samantha N

Keywords: Cancer Cell Lines; Cullin-2; E3 Ligase; Gel Electrophoresis; Hypoxia-Inducible Factor; Nedd8; Sccro; Squamous Cell Carcinoma; Von Hippel-Lindau Protein; Western Blotting

$17,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Brian Raught

Research Institute

6 shared papers, latest 2021

Ming-Sound Tsao

Department of Laboratory Medicine and Pathobiology

2 shared papers, latest 2021

Michael Milosevic

Radiation Medicine

2 shared papers, latest 2012

Gelareh Zadeh

Neurosurgery

2 shared papers, latest 2015

Fei-Fei Liu

Radiation Oncology

2 shared papers, latest 2009

Laurie Ailles

Department of Medical Biophysics

2 shared papers, latest 2025

Jason Moffat

Genetics and Genome Biology

1 shared papers, latest 2010

Ivan Topisirovic

Lady Davis Institute for Medical Research

1 shared papers, latest 2018

Julie St-Pierre

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2018

Jonathan Rocheleau

Division of Advanced Diagnostics-Metabolism

1 shared papers, latest 2023

Sue Tsai

Medical Microbiology and Immunology

1 shared papers, latest 2023

Scott Yuzwa

Department of Laboratory Medicine and Pathobiology

1 shared papers, latest 2021

Peter Siegel

Experimental Medicine

1 shared papers, latest 2018

Yasser Riazalhosseini

Human Genetics

1 shared papers, latest 2018

Sergio Grinstein

Cell Biology

1 shared papers, latest 2009

Karim Mekhail

Laboratory Medicine & Pathobiology

1 shared papers, latest 2020

Igor Stagljar

Biochemistry

1 shared papers, latest 2022

William Muller

Medicine

1 shared papers, latest 2018

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Vhl Dear Professor Ohh, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Assessment of HIF2α mutational pathogenicity using microscale thermophoresis." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Molecular characterization of pseudohypoxic cancer syndromes" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Michael Ohh

Research

Latest papers

Latest funding

Assessment of HIF2&#x3b1; mutational pathogenicity using microscale thermophoresis.

Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1&#x3b1; oxygen-dependent degradation domain.

Comparative single-cell transcriptomic profiling of patient-derived renal carcinoma cells in cellular and animal models of kidney cancer.

Glucose deprivation impairs hypoxia-inducible factor-1&#x3b1; synthesis.

Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1&#x3b1;.

Cathepsins L and B target HIF1&#x3b1; for oxygen-independent proteolytic cleavage.

Deficiency in PHD2-mediated hydroxylation of HIF2&#x3b1; underlies Pacak-Zhuang syndrome.

SHP2 Inhibition with TNO155 Increases Efficacy and Overcomes Resistance of ALK Inhibitors in Neuroblastoma.

Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1&#x3b1; to the Nrf2 Pathway.

Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmata.

Frequent collaborators

Brian Raught

Mitsuhiko Ikura

Ming-Sound Tsao

Michael Milosevic

Gelareh Zadeh

Fei-Fei Liu

Laurie Ailles

Jason Moffat

Ivan Topisirovic

Julie St-Pierre

Michael Pollak

Julie St-Pierre

Jonathan Rocheleau

Adam Shlien

Ivan Topisirovic

Laura Hulea

Sue Tsai

Scott Yuzwa

David Malkin

Simon-Pierre Gravel

Celia Greenwood

Peter Siegel

Yasser Riazalhosseini

Sergio Grinstein

Karim Mekhail

Igor Stagljar

Mark Lathrop

Minna Woo

William Muller

Assessment of HIF2α mutational pathogenicity using microscale thermophoresis.

Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain.

Glucose deprivation impairs hypoxia-inducible factor-1α synthesis.

Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α.

Cathepsins L and B target HIF1α for oxygen-independent proteolytic cleavage.

Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome.

Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1α to the Nrf2 Pathway.