Marius Locke, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Proteins and peptides Exercise physiology

Latest papers

BCL6 regulates skeletal muscle mass and mitochondrial bioenergetics.
Molecular metabolism · 2026
Skeletal Muscle Heat Shock Protein Content and the Repeated Bout Effect.
International journal of molecular sciences · 2024 · first author
Will artificial intelligence require chaperones?
Cell stress & chaperones · 2023 · first author

All 19 publications

Latest funding

Stress Markers in Concussed Athletes
CIHR · 2012 · Co-investigator
The Effects of Extracellular Heat Shock Proteins on Blood Pressure Regulation
CIHR · 2011 · Supervisor
$17,500
Constitutive and stress induced regulation/expression of stress proteins in skeletal muscle
NSERC · 1996 · Principal investigator
$106,375

All 3 grants and awards

19 publications.

01

BCL6 regulates skeletal muscle mass and mitochondrial bioenergetics.

Usmani SE, Leduc-Gaudet JP, Chau S, Bellissimo CA, Vohra S, Desjardins K, Pollock-Tahiri E, Shi I, Chun F, Capobianco A, Delisle P, Dupebe W, Cefis M, Marcangeli V, Ghebreselassie M, Liang YC, Seki Y, Mayaki D, Hussain S, Goligher E, Kapoor M, Locke M, Gouspillou G, Woo M

Molecular metabolism2026

DOI: 10.1016/j.molmet.2026.102367 PMID: 41985672

02

Skeletal Muscle Heat Shock Protein Content and the Repeated Bout Effect.

Locke M, Bruccoleri G

International journal of molecular sciences2024First author

DOI: 10.3390/ijms25074017 PMID: 38612826

03

Will artificial intelligence require chaperones?

Locke M

Cell stress & chaperones2023First author

DOI: 10.1007/s12192-023-01343-y PMID: 37097423

04

Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1.

Hogg DW, Reid AL, Dodsworth TL, Chen Y, Reid RM, Xu M, Husic M, Biga PR, Slee A, Buck LT, Barsyte-Lovejoy D, Locke M, Lovejoy DA

Frontiers in physiology2022

DOI: 10.3389/fphys.2022.1031264 PMID: 36523555

05

Methacrylic acid-based hydrogels enhance skeletal muscle regeneration after volumetric muscle loss in mice.

Carleton MM, Locke M, Sefton MV

Biomaterials2021

DOI: 10.1016/j.biomaterials.2021.120909 PMID: 34087582

06

Ovariectomy alters lengthening contraction induced heat shock protein expression.

Locke M, Salerno SA

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2020First author

DOI: 10.1139/apnm-2019-0212 PMID: 32339026

07

Leucine-Enriched Essential Amino Acids Improve Recovery from Post-Exercise Muscle Damage Independent of Increases in Integrated Myofibrillar Protein Synthesis in Young Men

Waskiw-Ford M, Hannaian S, Duncan J, Kato H, Sawan SA, Locke M, Kumbhare D, Moore D

Nutrients202054 citations

DOI: 10.3390/nu12041061

08

HSP72 expression is specific to skeletal muscle contraction type.

Bonello JP, Locke M

Cell stress & chaperones2019Senior author

DOI: 10.1007/s12192-019-00997-x PMID: 31077033

09

The cellular stress response of rat skeletal muscle following lengthening contractions.

Pollock-Tahiri E, Locke M

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2017Senior author

DOI: 10.1139/apnm-2016-0556 PMID: 28199794

10

Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions.

Holwerda AM, Locke M

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2014Senior author

DOI: 10.1139/apnm-2014-0118 PMID: 25356915

Stress Markers in Concussed Athletes

Co-investigatorCIHR2012Catalyst Grant - Mild Traumatic Brain Injury - Ontario

Principal investigators: Mainwaring, Lynda M

Keywords: Biochemical Markers; Biomarkers; Concussion Recovery; Concussion Symptoms; Mild Traumatic Brain Injury; Physiological Markers; Psychological Markers; Return-To-Play (Rtp); Stress Markers

The Effects of Extracellular Heat Shock Proteins on Blood Pressure Regulation

SupervisorCIHR2011Master's Award: Canada Graduate Scholarships

Principal investigators: Rohailla, Sagar

Keywords: Animal Research; Cardiovascular Physiology; Effects Of Extracellular Heat Shock Proteins; Exercise Physiology; Heat Shock Proteins; Hypertension; Inflammation; Proteomic Analysis; Skeletal Muscle Damage; Toll-Like Receptors

$17,500

Constitutive and stress induced regulation/expression of stress proteins in skeletal muscle

Principal investigatorNSERC1996Discovery Grants Program - Individual

Principal investigators: Locke, Marius

$106,375

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Pharmacology and Toxicology
Kinesiology
Department of Medicine
Orthopedics
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Daniel Moore

Faculty

1 shared papers, latest 2020

Dinesh A Kumbhare

Kinesiology

1 shared papers, latest 2020

Sabah Hussain

Medicine

1 shared papers, latest 2026

Minna Woo

Medicine

1 shared papers, latest 2026

Mohit Kapoor

Orthopedics

1 shared papers, latest 2026

Ewan Goligher

Department of Medicine

1 shared papers, latest 2026

Dalia Barsyte-Lovejoy

Pharmacology and Toxicology

1 shared papers, latest 2022

Gilles Gouspillou

Medicine

1 shared papers, latest 2026

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student: Proteins and peptides Dear Professor Locke, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "BCL6 regulates skeletal muscle mass and mitochondrial bioenergetics." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]