Micheline Piquette-Miller

Research

Read how they describe their research on their University of Toronto profile.

Fetal development and medicine Fertility and maternal health Pharmacology and pharmaceutical sciences, n.e.c.Drug discovery, design and delivery

Latest papers

Meta-analysis and systematic review on Sulfasalazine/5-ASA use during pregnancy: Impact on neonatal and pregnancy outcomes.
Reproductive toxicology (Elmsford, N.Y.) · 2025 · senior author
Designer Frankenproteins That Halt the Proliferation of Myc-Driven Cancer Cells.
Journal of medicinal chemistry · 2025
Linking TLR-7 Signaling to Downregulation of Placental P-Glycoprotein: Implications for Fetal Drug Exposure.
Pharmaceutics · 2025 · senior author

All 86 publications

Latest funding

Impact of Lupus on Maternal-Fetal Drug Disposition and Pregnancy Outcomes
CIHR · 2025 · Nominated PI
$983,026
The impact of systemic lupus erythematosus on the expression of placental drug transporters and maternal-fetal drug disposition in a pregnant mouse model of lupus.
CIHR · 2025 · Supervisor
$120,000
Delivery of Antiretroviral Drugs across Placental-Fetal Barriers: Relevance to in Utero Drug Toxicity
CIHR · 2023 · Co-investigator
$960,076

All 7 grants and awards

86 publications.

01

Meta-analysis and systematic review on Sulfasalazine/5-ASA use during pregnancy: Impact on neonatal and pregnancy outcomes.

Asthana R, Hamandi B, Brnabic A, Papadimitropoulos E, Piquette-Miller M

Reproductive toxicology (Elmsford, N.Y.)2025Senior author

DOI: 10.1016/j.reprotox.2025.108939 PMID: 40334871

02

Designer Frankenproteins That Halt the Proliferation of Myc-Driven Cancer Cells.

Ali M, Akel R, He F, Piquette-Miller M, Shin JA

Journal of medicinal chemistry2025

DOI: 10.1021/acs.jmedchem.5c01493 PMID: 40899573

03

Linking TLR-7 Signaling to Downregulation of Placental P-Glycoprotein: Implications for Fetal Drug Exposure.

Riera-Romo M, McColl ER, Piquette-Miller M

Pharmaceutics2025Senior author

DOI: 10.3390/pharmaceutics17060741 PMID: 40574053

04

Decreased expression of P-glycoprotein in the placenta of women with autoimmune disease.

Pollinzi A, Mirdamadi K, Karimian Pour N, Asthana-Nijjar R, Lee D, Nevo O, Piquette-Miller M

Drug metabolism and disposition: the biological fate of chemicals2025Senior author

DOI: 10.1016/j.dmd.2024.100031 PMID: 40023574

05

Altered Expression of BCRP Impacts Fetal Accumulation of Rosuvastatin in a Rat Model of Preeclampsia.

Dai W, Piquette-Miller M

Pharmaceutics2024Senior author

DOI: 10.3390/pharmaceutics16070884 PMID: 39065581

06

Use of Traditional and Proteomic Methods in the Assessment of a Preclinical Model of Preeclampsia.

Dai W, Pollinzi A, Piquette-Miller M

Drug metabolism and disposition: the biological fate of chemicals2023Senior author

DOI: 10.1124/dmd.122.001080 PMID: 37286362

07

Dysregulation of Amino Acid Transporters in a Rat Model of TLR7-Mediated Maternal Immune Activation.

McColl ER, Henderson JT, Piquette-Miller M

Pharmaceutics2023Senior author

DOI: 10.3390/pharmaceutics15071857 PMID: 37514044

08

The Effect of Tobacco Use on the Expression of Placental Transporters in Alaska Native Women.

McColl ER, Kwok J, Benowitz NL, Patten CA, Hughes CA, Koller KR, Flanagan CA, Thomas TK, Hiratsuka VY, Tyndale RF, Piquette-Miller M

Clinical pharmacology and therapeutics2023Senior author

DOI: 10.1002/cpt.2737 PMID: 36053152

09

COVID-19 Vaccines and the Virus: Impact on Drug Metabolism and Pharmacokinetics.

McColl ER, Croyle MA, Zamboni WC, Honer WG, Heise M, Piquette-Miller M, Goralski KB

Drug metabolism and disposition: the biological fate of chemicals2023

DOI: 10.1124/dmd.122.000934 PMID: 36273826

10

Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium.

Brouwer KLR, Evers R, Hayden E, Hu S, Li CY, Meyer Zu Schwabedissen HE, Neuhoff S, Oswald S, Piquette-Miller M, Saran C, Sjöstedt N, Sprowl JA, Stahl SH, Yue W

Clinical pharmacology and therapeutics2022

DOI: 10.1002/cpt.2605 PMID: 35390174

Impact of Lupus on Maternal-Fetal Drug Disposition and Pregnancy Outcomes

Nominated PICIHR2025Project Grant

Principal investigators: Piquette-Miller, Micheline R

Keywords: Autoimmune Disease; Cytokines; Drug Transporters; Lupus; Neonatal Outcomes; Pharmacokinetics; Placenta; Preeclampsia; Pregnancy; Real World Evidence

$983,026

The impact of systemic lupus erythematosus on the expression of placental drug transporters and maternal-fetal drug disposition in a pregnant mouse model of lupus.

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Nelles, Diana

Keywords: Drug Pharmacokinetics; Drug Safety; Drug Transporters; Fetal Drug Exposure; Hydroxychloroquine; Imiquimod-Induced Mouse Model Of Lupus; Lupus Pathology; Maternal-Fetal Health; Placental Biology; Pregnancy Research

$120,000

Delivery of Antiretroviral Drugs across Placental-Fetal Barriers: Relevance to in Utero Drug Toxicity

Co-investigatorCIHR2023Project Grant

Principal investigators: Bendayan, Reina; Serghides, Lena

Keywords: Drug Metabolic Enzymes; Drug Transporters; Fetal Drug Efficacy; Fetal Drug Toxicity; Hiv Drugs-Pharmacokinetics; Hiv Infection; Placenta- Fetal Drug Delivery; Placental-Fetal Barriers; Pregnancy; Sex Differences

$960,076

Effect of Maternal Disease on Placental Transporters and Fetal Drug Exposure

Nominated PICIHR2019Project Grant

Principal investigators: Piquette-Miller, Micheline R

Keywords: Autoimmune Disease; Cytokines; Drug Exposure; Drug Transporters; Fetus; Inflammation; Pharmacokinetics; Placenta; Pregnancy

$787,950

The effect of a viral mimetic on the expression of nutrient transporters: Exploring the link between maternal immune activation and Autism Spectrum Disorder

SupervisorCIHR2018Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: McColl, Eliza R

Keywords: Amino Acids; Animal Model; Autism Spectrum Disorder; Inflammation; Neurodevelopment; Pregnancy; Qrt-Pcr; Transporters; Western Blotting

$105,000

Effect of Maternal Disease on Maternal and Fetal Drug Exposure

Nominated PICIHR2013Operating Grant

Principal investigators: Piquette-Miller, Micheline R

Keywords: Abc Transporters; Antiretroviral Therapy; Drug Transport; Fetal Drug Exposure; Hiv Infection; Inflammation; Malaria; Pharmacokinetics; Placenta; Pregnancy

$626,555

Effect of Maternal Disease on Maternal and Fetal Drug Exposure

Nominated PICIHR2013Operating Grant - PA: HIV/AIDS Bridge Funding - Biomedical/Clinical Stream

Principal investigators: Piquette-Miller, Micheline R

Keywords: Abc Transporters; Antiretroviral Therapy; Drug Transport; Fetal Drug Exposure; Hiv Infection; Inflammation; Malaria; Pharmacokinetics; Placenta; Pregnancy

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Anesthesia
Medical Biophysics
Psychology
Rotman Research Institute
Obstetrics and Gynecology
Pharmaceutical Sciences
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Christine Allen

Medical Biophysics

17 shared papers, latest 2020

Payam Zahedi

Faculty

9 shared papers, latest 2012

Natalie Crown

Faculty

2 shared papers, latest 2021

Haibo Zhang

Anesthesia

1 shared papers, latest 2018

Stanley Read

Faculty

1 shared papers, latest 2009

Gideon Koren

Faculty

1 shared papers, latest 2010

Howard Berger

Obstetrics and Gynecology

1 shared papers, latest 2021

Ruslan Dorfman

Anesthesia

1 shared papers, latest 2018

Lena Serghides

Pharmaceutical Sciences

1 shared papers, latest 2020

Gordon Winocur

Psychology

1 shared papers, latest 2018

Gordon Winocur

Rotman Research Institute

1 shared papers, latest 2018

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Fetal development and medicine Dear Professor Piquette-Miller, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Meta-analysis and systematic review on Sulfasalazine/5-ASA use during pregnancy: Impact on neonatal and pregnancy outcomes." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Impact of Lupus on Maternal-Fetal Drug Disposition and Pregnancy Outcomes" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]