Faculty profile

Lena Serghides

ResearcherPharmaceutical SciencesUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Lena Serghides

Researcher

Pharmaceutical Sciences

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
30 publications in the last five years, latest in 2026.
Senior (last) author on 13 recent papers, a sign of leading a research group.
Principal investigator on 22 research grants (22 CIHR), most recently in 2024.
Supervised 3 trainees who won CIHR awards, most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

126

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Pregnancy Hiv Antiretrovirals Placenta Hiv Mouse Model Neurodevelopment Angiogenic Biomarkers

Latest papers

Pubertal onset in children with in-utero HIV/antiretroviral exposure in Botswana.
AIDS (London, England) · 2026
Brief Report: Is Gestational Exposure to HIV and Protease Inhibitors Associated With Timing of Pubertal Onset?
Journal of acquired immune deficiency syndromes (1999) · 2026 · first author
A mouse model of HIV in pregnancy: the EcoHIV+ pregnancy model.
EBioMedicine · 2025 · senior author

All 84 publications

Latest funding

ON-TRACK: Ontario Network for Trials, Research, and Advancement in Capacity-Building for HIV/STBBIs
CIHR · 2025 · Co-investigator
$800,000
Dolutegravir, impaired vascular remodelling, and hypertesion in pregnancy.
CIHR · 2024 · Nominated PI
$1,235,475
Building a Canadian Research Agenda for Children HIV-Exposed Uninfected
CIHR · 2024 · Nominated PI
$20,000

All 34 grants and awards

84 publications.

Pubertal onset in children with in-utero HIV/antiretroviral exposure in Botswana.

Jao J, Gochanour C, Williams PL, Schenkel S, Kgole S, Masasa G, Phale B, Kgathi C, Makhema J, Ralegoreng T, Masheto G, Shaw ND, Serghides L, Shapiro R, Lockman S, Powis KM

AIDS (London, England)2026

DOI: 10.1097/qad.0000000000004374 PMID: 41055964

Brief Report: Is Gestational Exposure to HIV and Protease Inhibitors Associated With Timing of Pubertal Onset?

Serghides L, Lee J, Jacobson DL, Geffner ME, DiMeglio LA, McFarland EJ, Powis KM, Williams PL, Jao J, Pediatric HIV/AIDS Cohort Study

Journal of acquired immune deficiency syndromes (1999)2026First author

DOI: 10.1097/qai.0000000000003801 PMID: 41259113

A mouse model of HIV in pregnancy: the EcoHIV+ pregnancy model.

Ranjbar M, Hsieh I, Collomb M, Serghides L

EBioMedicine2025Senior author

DOI: 10.1016/j.ebiom.2025.105943 PMID: 40992211

Structural brain differences in school-aged children who are HIV-exposed uninfected.

Forster EA, Syed B, Bowes J, Young J, Kapoor C, Head M, Lerch JP, Miller E, Brophy J, Bitnun A, Smith ML, Serghides L, Taylor MJ, Sled JG, KIND Study Group

BMC medicine2025

DOI: 10.1186/s12916-025-04332-3 PMID: 40859302

Bictegravir decreases expression of system L-amino acid transporters and inhibits leucine uptake activity in a human placental cell line.

Rasna RS, Dunk CE, Hoque MT, Bendayan R, Serghides L

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2025Senior author

DOI: 10.1016/j.biopha.2025.118291 PMID: 40570710

Brief Report: Low Placental Growth Factor Levels Mid-gestation Predict Small for Gestational Age in Pregnant Women With HIV.

Dunk CE, Powis KM, Legbedze J, Sun S, Mmasa KN, Kgole SW, Masasa G, Moyo S, Mohammed T, Yee LM, Mmalane MO, Makhema JM, Jao J, Serghides L

Journal of acquired immune deficiency syndromes (1999)2025Senior author

DOI: 10.1097/qai.0000000000003672 PMID: 40179283

Growth-promoting hormonal alterations in pregnant women living with HIV receiving dolutegravir-based antiretroviral treatment are associated with lower infant 1-year weight z-scores.

Powis KM, Jao J, Legbedze J, Dunk C, Mmasa KN, Kgole SW, Masasa G, Mohammed T, Makhema J, Moyo S, Geffner ME, Abrams EJ, Serghides L

Frontiers in pediatrics2025Senior author

DOI: 10.3389/fped.2025.1559877 PMID: 40787011

Intelligence and language outcomes in school-aged children who are HIV-exposed, uninfected: the role of sex, perinatal risk factors, and socioeconomic status.

Kahnami L, Smith ML, Bitnun A, Brophy J, Sled JG, Miller E, Bowes J, Hurtubise M, Serghides L, Young JM

Frontiers in pediatrics2025

DOI: 10.3389/fped.2025.1540420 PMID: 40746358

Effect of dolutegravir-based antiretroviral therapy on glycemic control in female mice.

Dontsova V, Mohan H, Yee A, Nguyen J, Fahmida M, Greene NDE, Copp AJ, Zash R, Jao J, Serghides L

Scientific reports2025Senior author

DOI: 10.1038/s41598-025-02130-8 PMID: 40467622

Fatty acid signatures in people with HIV: association with adverse pregnancy outcomes and offspring anthropometrics.

Fisher SA, Jao J, Yee LM, Serghides L, Chadwick EG, Jacobson DL, Pediatric HIV/AIDS Cohort Study (PHACS)

Journal of acquired immune deficiency syndromes (1999)2025

DOI: 10.1097/qai.0000000000003665 PMID: 40179278

ON-TRACK: Ontario Network for Trials, Research, and Advancement in Capacity-Building for HIV/STBBIs

Co-investigatorCIHR2025HIV/AIDS & STBBI Clinical Trials Research Network - Phase 2

Principal investigators: Mbuagbaw, Lawrence C; Ulusow, Asha M; Benoit, Anita C; Brophy, Jason C; Cooper, Curtis L; Habanyama, Muluba; Ibanez-Carrasco, Francisco; Jackson, Randy; Logie, Carmen; Loutfy, Mona R; Massaquoi, Notisha

Keywords: Capacity Building; Community; Equity, Diversity, Inclusion; Mentoring

$800,000

Dolutegravir, impaired vascular remodelling, and hypertesion in pregnancy.

Nominated PICIHR2024Project Grant

Principal investigators: Serghides, Lena

Keywords: Heart; Hiv Antiretroviral Therapy; Hypertension; Mmp; Placenta; Pregnancy; Vascular Stability; Zinc

$1,235,475

Building a Canadian Research Agenda for Children HIV-Exposed Uninfected

Nominated PICIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Serghides, Lena; Brophy, Jason C

Keywords: Children Hiv Exposed Uninfected; Hiv Antiretrovirals; Metabolic Health; Neurodevelopment; Research Priorities

$20,000

Investigating the effect of integrase strand transfer inhibitor (INSTI) treatment on fatty acid transport in the placenta

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Zutic, Adriana

Keywords: Fatty Acid Transport; Hiv/Aids; Human Clinical Samples; Integrase Strand Transfer Inhibitors; Mouse Model; Peroxisome Proliferator Activated Receptors; Placenta; Primary Cell Culture; Qpcr; Radiolabelled Transport Assay

$120,000

Expanding the KIND study planning meeting

Nominated PICIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Serghides, Lena

Keywords: Autism; Children Who Are Hiv Exposed But Uninfected; Hiv; Hiv Antiretrovirals; Neurodevelopment; Puberty

$20,000

Dolutegravir, impaired vascular remodelling, and hypertesion in pregnancy.

Nominated PICIHR2023Project Grant - Priority Announcement: HIV/AIDS and STBBI

Principal investigators: Serghides, Lena

Keywords: Angiogenic; Edema; Hiv Antiretroviral Therapy; Hypertension; Placenta; Pregnancy; Vascular Stability

$100,000

Delivery of Antiretroviral Drugs across Placental-Fetal Barriers: Relevance to in Utero Drug Toxicity

Principal investigatorCIHR2023Project Grant

Principal investigators: Bendayan, Reina; Serghides, Lena

Keywords: Drug Metabolic Enzymes; Drug Transporters; Fetal Drug Efficacy; Fetal Drug Toxicity; Hiv Drugs-Pharmacokinetics; Hiv Infection; Placenta- Fetal Drug Delivery; Placental-Fetal Barriers; Pregnancy; Sex Differences

$960,076

Canada Research Chair - Tier 1

Nominated PICIHR2022Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Serghides, Lena

Keywords: Crc

$1,400,000

Assessing the impact of in-utero exposure of anti-retroviral therapy on neurotoxicity, oxidative stress and mitochondrial functions in central nervous system of a mouse model

SupervisorCIHR2022Fellowship - Priority Announcement - HIV/AIDS and/or STBBI

Principal investigators: Dhume, Shreya H

Keywords: Cognitive Developement; Fetal Development; Hiv Infection And Antiretroviral Treatment; Neurodevelopment; Neurotoxicity; Pregnancy

$135,000

HIV antiretrovirals and placenta dysfunction - identifying the mechanisms leading to poor fetal growth

Nominated PICIHR2021Project Grant

Principal investigators: Serghides, Lena

Keywords: Angiogenic; Antiretroviral Therapy; Birth Outcomes; Hiv; Metabolic Function; Mouse Model; Placenta; Placenta Explant; Pregnancy

$925,650

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Lena Serghides

Research

Latest papers

Latest funding

Pubertal onset in children with in-utero HIV/antiretroviral exposure in Botswana.

Brief Report: Is Gestational Exposure to HIV and Protease Inhibitors Associated With Timing of Pubertal Onset?

A mouse model of HIV in pregnancy: the EcoHIV+ pregnancy model.

Structural brain differences in school-aged children who are HIV-exposed uninfected.

Bictegravir decreases expression of system L-amino acid transporters and inhibits leucine uptake activity in a human placental cell line.

Brief Report: Low Placental Growth Factor Levels Mid-gestation Predict Small for Gestational Age in Pregnant Women With HIV.

Growth-promoting hormonal alterations in pregnant women living with HIV receiving dolutegravir-based antiretroviral treatment are associated with lower infant 1-year weight z-scores.

Intelligence and language outcomes in school-aged children who are HIV-exposed, uninfected: the role of sex, perinatal risk factors, and socioeconomic status.

Effect of dolutegravir-based antiretroviral therapy on glycemic control in female mice.

Fatty acid signatures in people with HIV: association with adverse pregnancy outcomes and offspring anthropometrics.

Frequent collaborators

Mona Loutfy

Michael Silverman

Reina Bendayan

Rupert Kaul

Janet Raboud

Wangari Tharao

Jason Brophy

Wangari Tharao

Sharon Walmsley

Fiona Smaill

Scott Gray-Owen

Alexandra de Pokomandy

Christopher Mushquash

Michael Hawkes

Angela Kaida

Michael Silverman

Dionne Gesink

Notisha Massaquoi

Abigail Kroch

Notisha Massaquoi

Chao Wang

Fanta Ongoiba

Karl Jobst

Laura Erdman

Randall Jackson

John Kingdom