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Michelle Downes

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ProfessorDepartment of Laboratory Medicine & PathobiologyUniversity of Toronto

Michelle Downes

Professor

Department of Laboratory Medicine & Pathobiology

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

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7 publications in the last five years, latest in 2026.

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Publications

133

Citations

Collaborators

Grants

Publications by year

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Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Duct Quest: An international survey of genitourinary and community pathologists reveals diagnostic uncertainties in separating atypical intraductal proliferation from high-grade prostatic intraepithelial neoplasia and intraductal carcinoma of the prostate.
Human pathology · 2026
The Genitourinary Pathology Society and International Society of Urological Pathology Joint Expert Consultation Recommendations on intraductal carcinoma of the prostate.
Histopathology · 2026
Detection of Prostate Cancer in 3-Dimensional Pathology Datasets via Generative Immunolabeling.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2026

All 10 publications

Latest funding

Primary prostate cancer cells as novel models for patient therapy prediction
CIHR · 2023 · Co-investigator
$883,576
'Two-Step Authentication' for Optimal Prostate Cancer Risk Determination: An "Extracellular Vesicle"-Based Liquid Biopsy Followed by Multi-Parametric MRI.
CIHR · 2022 · Co-investigator
$1,637,100

All 2 grants and awards

10 publications.

Duct Quest: An international survey of genitourinary and community pathologists reveals diagnostic uncertainties in separating atypical intraductal proliferation from high-grade prostatic intraepithelial neoplasia and intraductal carcinoma of the prostate.

Bernhardt M, Bollen IF, Chan E, Cheng L, Collins K, Downes M, Greenland N, Iczkowski KA, Jufe L, Kweldam C, van Leenders G, Paner GP, Perry-Keene J, Scherping AK, Tsuzuki T, Varma M, Williamson SR, Wobker S, Zhou M, Zhou X, Shah RB, Kristiansen G

Human pathology2026

DOI: 10.1016/j.humpath.2026.106233 PMID: 42600754

The Genitourinary Pathology Society and International Society of Urological Pathology Joint Expert Consultation Recommendations on intraductal carcinoma of the prostate.

Shah RB, Varma M, Zhou M, Paner GP, Amin MB, Berney DM, Cheng L, Deng FM, Downes M, Eggener S, Ehdaie B, Epstein JI, Evans A, Fine SW, Greenland N, Guo C, Han B, Hirsch MS, Izkowski KA, Kench JG, Lotan TL, Magi-Galluzzi C, Miyamoto H, Nguyen JK, Tsuzuki T, van der Kwast TH, van Leenders GJ, Williamson SR, Wobker SE, Wu CL, Yang X, Kristiansen G

Histopathology2026

DOI: 10.1111/his.70046 PMID: 41384645

Detection of Prostate Cancer in 3-Dimensional Pathology Datasets via Generative Immunolabeling.

Serafin RB, Lopez JS, Chow S, Wang R, Zhao Y, Baraznenok E, Lan L, Bishop K, Downes M, Farre X, True LD, Lal P, Madabhushi A, Liu JTC

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2026

DOI: 10.1016/j.modpat.2026.100975 PMID: 41692323

Scalable 3D cell-interaction analysis via supercell graphs for prostate cancer risk stratification.

Zhao Y, Chow SSL, Yan R, Brenes D, Serafin R, Almagro-Pérez C, Song AH, Lal P, Chan E, Downes M, Baraznenok E, Lopez JS, Madabhush A, Mahmood F, True LD, Liu JTC

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.07.07.736891 PMID: 42465438

Unexpectedly high variability in determining tumour extent in prostatic biopsies: implications for active surveillance.

Bernhardt M, Weinhold L, Bremmer F, Chan E, Cheng L, Collins K, Downes M, Greenland N, Hommerding O, Iczkowski KA, Jufe L, Kreft T, van Leenders G, Oxley J, Perry-Keene J, Reis H, Schmid M, Tsuzuki T, Wobker S, Wiliamson SR, Kweldam C, Kristiansen G

Histopathology2025

DOI: 10.1111/his.15372 PMID: 39610035

Targeting PLOD2 suppresses invasion and metastatic potential in radiorecurrent prostate cancer.

Frame G, Leong H, Haas R, Huang X, Wright J, Emmenegger U, Downes M, Boutros PC, Kislinger T, Liu SK

BJC reports20247 citationsOpen Access

DOI: 10.1038/s44276-024-00085-3 PMID: 39184453

Accelerated growth and local progression of radiorecurrent prostate cancer in an orthotopic bioluminescent mouse model.

Frame G, Huang X, Haas R, Khan KA, Leong HS, Kislinger T, Boutros PC, Downes M, Liu SK

Scientific reports20241 citationsOpen Access

DOI: 10.1038/s41598-024-82546-w PMID: 39732766

miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA

Jessica L. Ray, Charles M. Haughey, Christianne Hoey, Jouhyun Jeon, Ross G. Murphy, Lara Dura-Perez, Nuala McCabe, Michelle R. Downes, Suneil Jain, Paul Christopher Boutros, Ian Geoffrey Mills, Stanley K. Liu

Cancer Letters201959 citationsOpen Access

DOI: 10.1016/j.canlet.2019.12.025 PMID: 31874245

Value of Increasing Biopsy Cores per Target with Cognitive MRI-targeted Transrectal US Prostate Biopsy.

Zhang M, Milot L, Khalvati F, Sugar L, Downes M, Baig SM, Klotz L, Haider MA

Radiology201952 citations

DOI: 10.1148/radiol.2019180712 PMID: 30694165

Integrated Molecular Analysis of Papillary Renal Cell Carcinoma and Precursor Lesions Unfolds Evolutionary Process from Kidney Progenitor-Like Cells.

Saleeb RM, Farag M, Ding Q, Downes M, Bjarnason G, Brimo F, Plant P, Rotondo F, Lichner Z, Finelli A, Yousef GM

The American journal of pathology201914 citationsOpen Access

DOI: 10.1016/j.ajpath.2019.07.002 PMID: 31381885

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Michelle Downes

Research

Latest papers

Latest funding

Duct Quest: An international survey of genitourinary and community pathologists reveals diagnostic uncertainties in separating atypical intraductal proliferation from high-grade prostatic intraepithelial neoplasia and intraductal carcinoma of the prostate.

The Genitourinary Pathology Society and International Society of Urological Pathology Joint Expert Consultation Recommendations on intraductal carcinoma of the prostate.

Detection of Prostate Cancer in 3-Dimensional Pathology Datasets via Generative Immunolabeling.

Scalable 3D cell-interaction analysis via supercell graphs for prostate cancer risk stratification.

Unexpectedly high variability in determining tumour extent in prostatic biopsies: implications for active surveillance.

Targeting PLOD2 suppresses invasion and metastatic potential in radiorecurrent prostate cancer.

Accelerated growth and local progression of radiorecurrent prostate cancer in an orthotopic bioluminescent mouse model.

miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA

Value of Increasing Biopsy Cores per Target with Cognitive MRI-targeted Transrectal US Prostate Biopsy.

Integrated Molecular Analysis of Papillary Renal Cell Carcinoma and Precursor Lesions Unfolds Evolutionary Process from Kidney Progenitor-Like Cells.

Primary prostate cancer cells as novel models for patient therapy prediction

'Two-Step Authentication' for Optimal Prostate Cancer Risk Determination: An "Extracellular Vesicle"-Based Liquid Biopsy Followed by Multi-Parametric MRI.

Frequent collaborators

Paul Boutros

Stanley Liu

Thomas Kislinger

Hon Leong

Linda Sugar

Laurence Klotz

George Yousef

Rola Saleeb

JJ Wright

Urban Emmenegger

Farzad Khalvati

Kabir Khan

Jessica Wright

Antonio Finelli