Sean Egan, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Breast Cancer Mouse Modeling Lobular Breast Cancer Genetics Theraepeutics Tumor Suppressors Combination Therapy Estrogen Receptor

Latest papers

A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance.
Developmental cell · 2025

All 1 publications

Latest funding

Plakoglobin, a regulator of pluripotency and Wnt/beta-Catenin-mediated transformation
CIHR · 2024 · Nominated PI
$65,000
16q hemizygous loss in breast cancer: The central driver for tumor initiation, invasion and progression
CIHR · 2021 · Nominated PI
$979,200
Targeting the immune landscape at presentation and relapse of Immune-Related Lobular Breast Cancer
CIHR · 2019 · Nominated PI
$956,250

All 7 grants and awards

1 publications.

01

A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance.

Fan JJ, Erickson AW, Carrillo-Garcia J, Wang X, Skowron P, Wang X, Chen X, Shan G, Dou W, Bahrampour S, Xiong Y, Dong W, Abeysundara N, Francisco MA, Pusong RJ, Wang W, Li M, Ying E, Suárez RA, Farooq H, Holgado BL, Wu X, Daniels C, Dupuy AJ, Cadiñanos J, Bradley A, Bagchi A, Moriarity BS, Largaespada DA, Morrissy AS, Ramaswamy V, Mack SC, Garzia L, Dirks PB, Li X, Wanggou S, Egan S, Sun Y, Taylor MD, Huang X

Developmental cell2025

DOI: 10.1016/j.devcel.2025.01.001 PMID: 39862856

Plakoglobin, a regulator of pluripotency and Wnt/beta-Catenin-mediated transformation

Nominated PICIHR2024CIHR - ICR / Cancer Research Society Partnership - Res. Grants - Breast Cancer

Principal investigators: Egan, Sean E

Keywords: Breast Cancer

$65,000

16q hemizygous loss in breast cancer: The central driver for tumor initiation, invasion and progression

Nominated PICIHR2021Project Grant

Principal investigators: Egan, Sean E

Keywords: Breast Cancer; Genetics; Mouse Modeling; Theraepeutics; Tumor Suppressors

$979,200

Targeting the immune landscape at presentation and relapse of Immune-Related Lobular Breast Cancer

Nominated PICIHR2019Project Grant

Principal investigators: Egan, Sean E

Keywords: Breast Cancer; Combination Therapy; Estrogen Receptor; Immune Checkpoint Therapy; Immunotherapy; Lobular Breast Cancer; Metastasis; Mouse Modeling; Progression; Recurrence

$956,250

Notch as master regulator of breast cancer subtype and intratumoral heterogeneity

Nominated PICIHR2017Joint Canada-Israel Health Research Program

Principal investigators: Egan, Sean E; Ben-Porath, Ittai

Keywords: Asymmetry; Breast Cancer; Cell Fate; Heterogeneity; Human Culture Systems; Mouse Models; Notch; P53; Polycomb Complexes

Chromosome 16q, a Cancer Suppressor Chromosome Arm

Nominated PICIHR2016Project Grant

Principal investigators: Egan, Sean E

Keywords: Breast Cancer; Cbfb; Cdh1; Chromosome 16q; Chromosome Engineering; Ctcf; E-Cadherin; Lobular Breast Cancer; Pik3ca; Tumor Suppressor

$741,565

Defining the function of Gata3 and TRPS1, A GATA-like protein, in BC

Nominated PICIHR2014Operating Grant

Principal investigators: Egan, Sean E

Keywords: Breast Cancer; Gata3; Mouse Genetics; Pi3k; Rad21; Transposons; Trps1

$742,832

Addressing tumor heterogeneity through identification of subgroup-specific "shared maintenance genes" - the right target for each cancer

Nominated PICIHR2010Team Grant: Terry Fox New Frontiers Program in Cancer

Principal investigators: Egan, Sean E; Taylor, Michael D; Woodgett, James (Jim) R; Zacksenhaus, Eldad

Keywords: Breast Cancer; Medulloblastoma; Metastasis; Oncogene Addiction; P53; Pi3k; Rb; Shared Maintenance Genes; Shh; Wnt

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Department of Molecular Genetics
Developmental Stem Cell Biology
Toronto General Research Institute
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Yu Sun

Toronto General Research Institute

1 shared papers, latest 2025

Xi Huang

Faculty

1 shared papers, latest 2025

Vijay Ramaswamy

Developmental Stem Cell Biology

1 shared papers, latest 2025

Livia Garzia

Faculty

1 shared papers, latest 2025

Wei Wang

Faculty

1 shared papers, latest 2025

Livia Garzia

Faculty

1 shared papers, latest 2025

Write to this professor

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Applying for

Mention their CIHR grant from 2024

Subject: Prospective PhD student: Breast Cancer Dear Professor Egan, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Plakoglobin, a regulator of pluripotency and Wnt/beta-Catenin-mediated transformation" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]