Faculty profile

Xi Huang

ResearcherUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Xi Huang

Researcher

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
26 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (5 CIHR, 1 NSERC), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Mouse Models Ion Channel Crc Brain Tumor Therapeutic Target Fluid Shear Stress Mechanotransduction Medulloblastoma

Latest papers

Profiling the molecular and physiological effects of senolytic treatment on aged mice identifies immune, fibrotic and metabolic remodeling.
Nature aging · 2026
Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.
Nature biomedical engineering · 2026 · senior author
Integrating Single-Cell Transcriptome-Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune-Related Drug Targets for Cancers.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025

All 41 publications

Latest funding

Defining a targetable mechano-metastatic cascade to treat medulloblastoma metastasis
CIHR · 2023 · Nominated PI
$765,000
Canada Research Chair - Tier 2
CIHR · 2022 · Nominated PI
$500,000
A Magnetic Microrobotic System with Raman Spectroscopy and Confocal Fluorescence Microscopy for Molecular Diagnostics and Cell Biology
NSERC · 2021 · Co-investigator
$150,000

All 9 grants and awards

41 publications.

Profiling the molecular and physiological effects of senolytic treatment on aged mice identifies immune, fibrotic and metabolic remodeling.

Hou J, Chen KX, Xiao QN, Hu C, Wei J, Jiang YZ, Liu L, He C, Huang M, Jiao YR, Tang X, Zou NY, He WZ, Sun YC, Zhou YY, Huang X, Zeng C, Lei GH, Wang YL, Li CJ

Nature aging2026

DOI: 10.1038/s43587-026-01130-1 PMID: 42310394

Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.

Min HK, Zhao H, Bahcheli A, Pan P, Chan J, Chen J, Low E, Zhou Y, Wang X, Bajic S, Peng R, Wanggou S, Yang Q, Zhang RDY, Wang L, Ren X, Qi H, Shi Y, Hayes MN, Ciruna B, Reimand J, Liu X, Huang X

Nature biomedical engineering2026Senior author

DOI: 10.1038/s41551-025-01487-5 PMID: 40897897

Integrating Single-Cell Transcriptome-Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune-Related Drug Targets for Cancers.

Zheng J, Yang Q, Liu H, Zhao H, Wang S, Liu Y, Wu X, Ding Y, Ying H, Ye Y, Huang X, Ye L, Zheng R, Lin H, Li M, Wang T, Zhao Z, Xu M, Duan Y, Guo H, Yuan Z, Haycock P, Davey Smith G, Martin RM, Ning G, Hu F, Wang W, Gaunt TR, Lu J, Bi Y

Advanced science (Weinheim, Baden-Wurttemberg, Germany)2025

DOI: 10.1002/advs.202507451 PMID: 41216857

Role of repulsive guidance signaling and GPR180 in pediatric low-grade glioma infiltration.

Jung G, Liang Z, Jain P, Deutsch HM, Li F, Rathi KS, Sun Z, Chen X, Straka J, Kazerooni AF, Sun Y, Koptyra MP, Sanchez-Maldonado S, Familiar A, Waanders AJ, Nabavizadeh A, Huang X, Resnick AC, Song Y

NPJ precision oncology2025

DOI: 10.1038/s41698-025-01121-2 PMID: 41219403

Glutamate promotes glioma growth via a non-excitable, receptor tyrosine kinase-mediated mechanism.

Huang X, Taylor MD

Neuron2025First author

DOI: 10.1016/j.neuron.2025.10.007 PMID: 41197605

Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process.

Nör C, Kharas K, Rasnitsyn A, Vladoiu MC, Cho NW, Young JS, Nör F, Mankahla N, Haapasalo J, Nordfors K, Rapic S, Skowron P, Suárez RA, Bahcheli AT, Ocsenas O, Chen X, Bahrampour S, Momin A, Sundaresan L, Ong W, Hendrikse LD, Abeysundara N, Juraschka K, Ly M, Pallota JG, Douglas T, Huang N, Wang H, Mak E, Qin L, Liu J, Shen L, Luu B, Manno A, Kumar SA, Donovan LK, Fong V, Richman C, Daniels C, Garzia L, Rich JN, Hawkins C, Wu X, DaCosta R, Reimand J, Huang X, Ramaswamy V, Raleigh DR, Taylor MD

Developmental cell2025

DOI: 10.1016/j.devcel.2025.06.016 PMID: 40609543

A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance.

Fan JJ, Erickson AW, Carrillo-Garcia J, Wang X, Skowron P, Wang X, Chen X, Shan G, Dou W, Bahrampour S, Xiong Y, Dong W, Abeysundara N, Francisco MA, Pusong RJ, Wang W, Li M, Ying E, Suárez RA, Farooq H, Holgado BL, Wu X, Daniels C, Dupuy AJ, Cadiñanos J, Bradley A, Bagchi A, Moriarity BS, Largaespada DA, Morrissy AS, Ramaswamy V, Mack SC, Garzia L, Dirks PB, Li X, Wanggou S, Egan S, Sun Y, Taylor MD, Huang X

Developmental cell2025Senior author

DOI: 10.1016/j.devcel.2025.01.001 PMID: 39862856

Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth.

Abeysundara N, Rasnitsyn A, Fong V, Bahcheli A, Van Ommeren R, Juraschka K, Vladoiu M, Ong W, Livingston B, de Antonellis P, Ly M, Holgado BL, Sirbu O, Bahrampour S, Min HK, Fan J, Nor C, Visvanathan A, Zhang J, Wang H, Qin L, Huang N, Pallotta J, Douglas T, Mak E, Su H, Ng K, Zhang KY, Daniels C, Lucas CG, Eberhart CG, Liu H, Jiang T, Notta F, Ramaswamy V, Reimand J, Gallo M, Rich JN, Wu X, Huang X, Taylor MD

Nature cell biology2025

DOI: 10.1038/s41556-025-01660-7 PMID: 40263572

Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling.

Yang Y, Hao C, Jiao T, Yang Z, Li H, Zhang Y, Zhang W, Doherty M, Sun C, Yang T, Li J, Wu J, Zhang M, Wang Y, Xie D, Wang T, Wang N, Huang X, Li C, Gonzalez FJ, Wei J, Xie C, Zeng C, Lei G

Science (New York, N.Y.)2025

DOI: 10.1126/science.adt0548 PMID: 40179178

OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma.

Desai K, Wanggou S, Luis E, Whetstone H, Yu C, Vanner RJ, Selvadurai HJ, Lee L, Vijay J, Jaramillo JE, Fan J, Guilhamon P, Kushida M, Li X, Stein G, Kesari S, Simons BD, Huang X, Dirks PB

Nature communications2025

DOI: 10.1038/s41467-024-54858-y PMID: 39904987

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Xi Huang

Research

Latest papers

Latest funding

Profiling the molecular and physiological effects of senolytic treatment on aged mice identifies immune, fibrotic and metabolic remodeling.

Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.

Integrating Single-Cell Transcriptome-Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune-Related Drug Targets for Cancers.

Role of repulsive guidance signaling and GPR180 in pediatric low-grade glioma infiltration.

Glutamate promotes glioma growth via a non-excitable, receptor tyrosine kinase-mediated mechanism.

Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process.

A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance.

Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth.

Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling.

OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma.

Defining a targetable mechano-metastatic cascade to treat medulloblastoma metastasis

Canada Research Chair - Tier 2

A Magnetic Microrobotic System with Raman Spectroscopy and Confocal Fluorescence Microscopy for Molecular Diagnostics and Cell Biology

A BioAFM for Intracellular, Cellular, and Tissue Measurement and Manipulation

A Magnetic Micromanipulation System for Intra-Cellular and Intra-Tissue Mechanics

Targeting potassium channel to disrupt the cellular hierarchy and suppress malignant growth of pediatric brain tumor

Canada Research Chair - Tier 2

Establishing chloride intracellular channel CLIC1 as a therapeutic target for pediatric brain tumor

Bioelectrical signalling by ion channels in cell cycle

Frequent collaborators

Yu Sun

Vijay Ramaswamy

Livia Garzia

Xinyu Liu

Lu-Yang Wang

Chi-Chung Hui

David Malkin

Nada Jabado

Tae-Hee Kim

Livia Garzia

Stephane Angers

Sevan Hopyan

Cynthia Hawkins

Ellen Langille

Madeline Hayes

Kyoung-Han Kim

Faiyaz Notta

Mark Bernstein

Eric Bouffet

Jüri Reimand

Ute Bartels

Wei Wang

Inanc Birol

Sean Egan

Lincoln Stein

Janet Rossant

Gary Bader

Brian Ciruna

Sunit Das

Ran Kafri

Daniel Schramek

Uri Tabori

Trevor Pugh

Ralph Dacosta