Faculty profile

Shinya Ito

ResearcherInternal MedicineUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Shinya Ito

Researcher

Internal Medicine

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
20 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (7 CIHR), most recently in 2018.
Supervised 1 trainee who won CIHR awards, most recently in 2009.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

105

Publications

122

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Drug Safety Pediatrics Pharmacokinetics Women'S Health Atypical Femur Fractures Genetic Analysis Osteoporosis Risk Factors

Latest papers

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study.
British journal of clinical pharmacology · 2026
A unified physiologically based pharmacokinetic model for low-to-high oral, subcutaneous, and intravenous dose of methotrexate in humans.
Journal of pharmaceutical sciences · 2026
The "route cause" of methotrexate-induced brain structure changes in a juvenile mouse model: Comparison of systemic and CNS-targeted chemotherapy.
Neurotoxicology · 2026

All 105 publications

Latest funding

How does chemotherapy to treat childhood cancer affect brain development?
CIHR · 2019 · Co-investigator
$933,300
Drugs in Breast Milk
CIHR · 2018 · Nominated PI
$680,851
Clinical and Genetic Risk Factors for Atypical Femur Fractures
CIHR · 2017 · Principal investigator
$1,996,652

All 14 grants and awards

105 publications.

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study.

Tomari K, Verstegen RHJ, Cruz C, Chung E, Azim A, Ito S, Lewis TR

British journal of clinical pharmacology2026

DOI: 10.1002/bcp.70672 PMID: 42385200

A unified physiologically based pharmacokinetic model for low-to-high oral, subcutaneous, and intravenous dose of methotrexate in humans.

Kim MS, Wang S, Mian P, Theoret Y, Autmizguine J, Ito S, Edginton AN

Journal of pharmaceutical sciences2026

DOI: 10.1016/j.xphs.2026.104348 PMID: 42235850

The "route cause" of methotrexate-induced brain structure changes in a juvenile mouse model: Comparison of systemic and CNS-targeted chemotherapy.

Choi SE, Ayoub T, Lee G, Wheeler AL, Guger SL, Weksberg R, Ito S, Schachar RJ, Hitzler J, Nieman BJ

Neurotoxicology2026

DOI: 10.1016/j.neuro.2025.103363 PMID: 41386426

Il-6 knockout reduces doxorubicin-induced toxicity in the developing mouse brain.

Yeung J, Quach H, Wong AP, Wheeler AL, Weksberg R, Guger SL, Schachar RJ, Ito S, Hitzler J, Nieman BJ

Brain, behavior, and immunity2025

DOI: 10.1016/j.bbi.2025.06.034 PMID: 40588079

Impaired Drug Metabolism Caused by Compound Heterozygous Loss-of-Function Variants in CYP3A4: A Case Report.

Kang HB, Cohn I, Mahant S, Costain G, Ito S, Verstegen RHJ

Clinical pharmacology and therapeutics2025

DOI: 10.1002/cpt.3693 PMID: 40296506

Optimizing proton-pump inhibitor therapy in paediatric eosinophilic esophagitis through CYP2C19 pharmacogenetic testing.

Scodellaro S, Bortolin KA, Marcon MA, Verstegen RHJ, Da Silva S, Ito S, Lewis T, Jones NL, Cohn I, Hulst JM

Journal of the Canadian Association of Gastroenterology2025

DOI: 10.1093/jcag/gwaf003 PMID: 40567296

Reduction of tumor necrosis factor (TNF) in milk of women receiving anti-TNF antibody.

Sepiashvili L, Brydon A, Koroshegyi C, Gold A, Dalvi P, Ghayoori S, Rahman M, Huang V, Maxwell C, Nguyen GC, Ito S

Pediatric research2025Senior author

DOI: 10.1038/s41390-024-03672-9 PMID: 39487320

Pregnancy-associated exposure reduction to medications used for antiphospholipid syndrome: a systematic review.

Zarek J, Brydon A, Spitzer K, Laskin C, Ito S

EULAR rheumatology open2025Senior author

DOI: 10.1016/j.ero.2025.03.001 PMID: 42367607

Vincristine-induced brain toxicity is reduced with prevention of peripheral axon degeneration in Sarm1 knockout mice.

Yeung J, Hsu P, Mak J, Darbandi A, Wheeler AL, Weksberg R, Guger SL, Schachar RJ, Ito S, Hitzler J, Nieman BJ

Acta neuropathologica communications2025

DOI: 10.1186/s40478-025-02171-0 PMID: 41419972

DNA methylation alterations in acute lymphoblastic leukemia survivors with late neurocognitive deficits.

Goodman SJ, Butcher DT, Guger SL, Diehl E, Brzezinski J, Spiegler B, Nieman BJ, Kallurkar P, Boulet Craig A, Krajinovic M, Laniel J, Laverdière C, Sinnett D, Lippé S, Turinsky A, Shago M, Strug LJ, Ito S, Hitzler JK, Schachar R, Weksberg R

Leukemia2025

DOI: 10.1038/s41375-025-02779-0 PMID: 41107616

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Shinya Ito

Research

Latest papers

Latest funding

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study.

A unified physiologically based pharmacokinetic model for low-to-high oral, subcutaneous, and intravenous dose of methotrexate in humans.

The "route cause" of methotrexate-induced brain structure changes in a juvenile mouse model: Comparison of systemic and CNS-targeted chemotherapy.

Il-6 knockout reduces doxorubicin-induced toxicity in the developing mouse brain.

Impaired Drug Metabolism Caused by Compound Heterozygous Loss-of-Function Variants in CYP3A4: A Case Report.

Optimizing proton-pump inhibitor therapy in paediatric eosinophilic esophagitis through CYP2C19 pharmacogenetic testing.

Reduction of tumor necrosis factor (TNF) in milk of women receiving anti-TNF antibody.

Pregnancy-associated exposure reduction to medications used for antiphospholipid syndrome: a systematic review.

Vincristine-induced brain toxicity is reduced with prevention of peripheral axon degeneration in Sarm1 knockout mice.

DNA methylation alterations in acute lymphoblastic leukemia survivors with late neurocognitive deficits.

Frequent collaborators

Gideon Koren

Rosanna Weksberg

Johann Hitzler

Marsha Campbell-Yeo

Yaron Finkelstein

Anna Taddio

Savithiri Ratnapalan

Sarah Bowdin

Sanjay Mahant

Russell Schachar

Jennifer Crosbie

Vibhuti Shah

Upton Allen

Wei Wang

Gregory Costain

Eriskay Liston

Zubin Austin

Erin Chung

Jordan Mak

John Semple

Anne-Marie Guerguerian

Colin Ross

Vibhuti Shah

David Lillicrap

Jason Matthews

Michael Brudno

Angelo Canty

Colin Ross

Alfonso Iorio

Katalin Ivanyi