Faculty profile

Andrea Edginton

ResearcherSchool of PharmacyUniversity of Waterloo

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Waterloo directory, so their courses may be missing. Find their university profile.

Andrea Edginton

Researcher

School of Pharmacy

Natural Sciences

University of Waterloo

Waterloo, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
26 publications in the last five years, latest in 2026.
Senior (last) author on 14 recent papers, a sign of leading a research group.
Principal investigator on 4 research grants (3 NSERC, 1 CIHR), most recently in 2024.
Supervisor on 6 trainee awards (6 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

pharmacokinetics physiologically based toxicokinetic model risk assessment dermal pediatric markov chain monte carlo bayesian in vitro in vivo extrapolation

Latest papers

Symptoms, Diagnosis, and Treatment for Women and Girls With Hemophilia: A Narrative Review
Haemophilia · 2026 · senior author
Country-level prediction of blood type distribution in hemophilia A in support of factor VIII consumption
Research and Practice in Thrombosis and Haemostasis · 2026 · senior author
Factor IX gene variants may influence the pharmacokinetic profile of patients with hemophilia B treated with FIX-Fc or N9-GP extended half-life FIX concentrates.
Journal of Thrombosis and Haemostasis · 2026

All 43 publications

Latest funding

Advancing neonatal exposure risk assessment to drug use during lactation using Physiologically-based pharmacokinetic modeling
CIHR · 2025 · Supervisor
$120,000
A Bayesian inferential and extrapolation framework for in vivo exposure assessment following dermal application of sunscreens and cosmetics using state-of-the-art mechanistic PBPK models
NSERC · 2024 · Principal investigator
$54,000
Practical use of a novel clinical resource to address medication use during breastfeeding in the context of current practice
CIHR · 2021 · Supervisor
$6,000

All 11 grants and awards

43 publications.

Symptoms, Diagnosis, and Treatment for Women and Girls With Hemophilia: A Narrative Review

Hirniak S, Samuel C, Aditi F, Abu Ghazaleh H, Rotellini D, Pai M, Edginton A

Haemophilia2026Senior author

DOI: 10.1111/hae.70359

Country-level prediction of blood type distribution in hemophilia A in support of factor VIII consumption

Chelle P, Hirniak S, Hajducek D, Iorio A, Edginton A

Research and Practice in Thrombosis and Haemostasis2026Senior author

DOI: 10.1016/j.rpth.2026.103356

Factor IX gene variants may influence the pharmacokinetic profile of patients with hemophilia B treated with FIX-Fc or N9-GP extended half-life FIX concentrates.

Matino D, Al-Housni Z, Samelson-Jones B, Chelle P, Castaman G, Teitel J, Jackson S, Lillicrap D, Keepanasseril A, Chan A

Journal of Thrombosis and Haemostasis2026

DOI: 10.1016/j.jtha.2026.08.010

Defining Safe and Effective Cefazolin Dosing Regimens for MSSA Infections in the CNS: Leveraging Sparse Real-World Data and PBPK Modeling.

Dubinsky S, McIntyre M, Kim MS, Hawryluk L, Edginton A

European journal of drug metabolism and pharmacokinetics2026Senior author

DOI: 10.1007/s13318-025-00981-0 PMID: 41642564

Physiologically Based Pharmacokinetic Modeling of Oxcarbazepine to Characterize Its Disposition in Children with Obesity.

Maglalang PD, Sinha J, Helfer VE, Edginton A, Zimmerman K, Hornik CD, Muller WJ, Rathore M, Benjamin DK, Chen JY, Anand R, Gonzalez D, Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee

Journal of clinical pharmacology2026

DOI: 10.1002/jcph.70107 PMID: 41020741

Midazolam Dosing During CRRT: A Combined Ex Vivo and Physiologically-Based Pharmacokinetic Approach.

McKnite AM, Hamadeh A, Hunt JP, Green DJ, Imburgia C, Whelan A, Hudson R, Chevalier A, Mathis CL, Yang MJ, Dwyer JP, Edginton A, Watt KM

CPT: pharmacometrics & systems pharmacology2026

DOI: 10.1002/psp4.70240 PMID: 42033156

Transforming Treatment: The Impact of Bariatric Surgery on Oral Drug Absorption.

Wigg D, Edginton A, Jones MD, Fotaki N

Obesity reviews : an official journal of the International Association for the Study of Obesity2026

DOI: 10.1111/obr.70044 PMID: 41319205

A Global Cross‐Sectional Database Study of Low Dose FVIII SHL Prophylaxis in Haemophilia A

Hajducek DM, Sinkovic O, Chelle P, Iorio A, Edginton A

Haemophilia2025Senior author

DOI: 10.1111/hae.70061

Exploring the Impact of Laboratory Reagents on Pharmacokinetic Profiling

Chelle P, Hajducek D, Iserman E, Iorio A, Edginton A, Group TIPS

Haemophilia2025Senior author

DOI: 10.1111/hae.70021

An Open-Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design.

Hamadeh A, Pellowe M, Chelle P, Yeung CHT, Otalvaro J, Yamada W, Bartroff J, Kryshchenko A, Dallmann A, Solodenko J, Lippert J, Tsakalozou E, Neely M, Edginton A

CPT: pharmacometrics & systems pharmacology2025Senior author

DOI: 10.1002/psp4.70115 PMID: 40990143

Advancing neonatal exposure risk assessment to drug use during lactation using Physiologically-based pharmacokinetic modeling

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Wang, Shirley

Keywords: Breastfeeding; Drug Safety; Drugs In Lactation; Pediatrics; Pharmacokinetics; Physiologically-Based Pharmacokinetic Modeling; Risk Assessment; Women'S Health

$120,000

A Bayesian inferential and extrapolation framework for in vivo exposure assessment following dermal application of sunscreens and cosmetics using state-of-the-art mechanistic PBPK models

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Edginton, Andrea

Keywords: pharmacokinetics; physiologically based toxicokinetic model; risk assessment; dermal; pediatric; markov chain monte carlo; bayesian; in vitro in vivo extrapolation; sunscreen; impurities

$54,000

Practical use of a novel clinical resource to address medication use during breastfeeding in the context of current practice

SupervisorCIHR2021Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Yeung, Cindy

Keywords: Breastfeeding; Health Care Providers; Lactation; Medication; Phsysiologically Based Pharmacokinetic Modeling; Safety

$6,000

Targeting Neuroplasticity After Neonatal Brain Injury

Co-investigatorSSHRC2021New Frontiers in Research Fund - Exploration

Principal investigators: Kalish, Brian

Keywords: brain injury newborn neuroprotection neuroplasticity hypoxic ischemic encephalopathy

$249,324

Translating milk pharmacokinetic data into infant plasma level prediction: an application of population pharmacokinetics and infant physiologically-based population pharmacokinetic models to predict drug exposure to breastfeeding infants

SupervisorCIHR2019Doctoral - PA - Canada Graduate Scholarship to Honor Nelson Mandela

Principal investigators: Yeung, Cindy

Keywords: Drug Safety; Pediatrics; Pharmacokinetics; Women'S Health

$105,000

Drugs in Breast Milk

Principal investigatorCIHR2018Project Grant

Principal investigators: Ito, Shinya; Autmizguine, Julie; Edginton, Andrea

Keywords: Drug Safety; Pediatrics; Pharmacokinetics; Women'S Health

$680,851

PBTK modeling and simulation framework to identify critical data requirements for efficient and effective pediatric risk assessment

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Edginton, Andrea

$168,000

Use of population pharmacokinetics to improve safety and efficiency of hemophilia treatment

SupervisorCIHR2017Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: McEneny-King, Alanna

Keywords: Clinical Trial; Comparative Effectiveness Research; Hemophilia Treatment; Patient-Centred Outcomes; Web Accessible Population Pharmacokinetics Service

$6,000

Physiologically-based pharmacokinetic modelling of antibody-based drugs in children: Model development and population applications

SupervisorCIHR2017Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Malik, Paul R

Keywords: Antibody-Drug Conjugates; Biologics; Drug Metabolism; Monoclonal Antibodies; Pediatrics; Pharmacokinetics; Pharmacology; Pharmacy; Physiologically-Based Pharmacokinetic Modelling; Physiology

$105,000

Development of pharmacokinetic models for factor VIII and factor IX for use in individualization of dosing

SupervisorCIHR2016Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: McEneny-King, Alanna

Keywords: Dose Individualization; Hemophilia A; Hemophilia B; Model Development And Evaluation; Nonlinear Mixed Effects Modelling; Population Pharmacokinetics

$105,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: pharmacokinetics Dear Professor Edginton, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Symptoms, Diagnosis, and Treatment for Women and Girls With Hemophilia: A Narrative Review" (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "A Bayesian inferential and extrapolation framework for in vivo exposure assessment following dermal application of sunscreens and cosmetics using state-of-the-art mechanistic PBPK models" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Andrea Edginton

Research

Latest papers

Latest funding

Symptoms, Diagnosis, and Treatment for Women and Girls With Hemophilia: A Narrative Review

Country-level prediction of blood type distribution in hemophilia A in support of factor VIII consumption

Factor IX gene variants may influence the pharmacokinetic profile of patients with hemophilia B treated with FIX-Fc or N9-GP extended half-life FIX concentrates.

Defining Safe and Effective Cefazolin Dosing Regimens for MSSA Infections in the CNS: Leveraging Sparse Real-World Data and PBPK Modeling.

Physiologically Based Pharmacokinetic Modeling of Oxcarbazepine to Characterize Its Disposition in Children with Obesity.

Midazolam Dosing During CRRT: A Combined Ex Vivo and Physiologically-Based Pharmacokinetic Approach.

Transforming Treatment: The Impact of Bariatric Surgery on Oral Drug Absorption.

A Global Cross‐Sectional Database Study of Low Dose FVIII SHL Prophylaxis in Haemophilia A

Exploring the Impact of Laboratory Reagents on Pharmacokinetic Profiling

An Open-Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design.

Advancing neonatal exposure risk assessment to drug use during lactation using Physiologically-based pharmacokinetic modeling

A Bayesian inferential and extrapolation framework for in vivo exposure assessment following dermal application of sunscreens and cosmetics using state-of-the-art mechanistic PBPK models

Practical use of a novel clinical resource to address medication use during breastfeeding in the context of current practice

Targeting Neuroplasticity After Neonatal Brain Injury

Translating milk pharmacokinetic data into infant plasma level prediction: an application of population pharmacokinetics and infant physiologically-based population pharmacokinetic models to predict drug exposure to breastfeeding infants

Drugs in Breast Milk

PBTK modeling and simulation framework to identify critical data requirements for efficient and effective pediatric risk assessment

Use of population pharmacokinetics to improve safety and efficiency of hemophilia treatment

Physiologically-based pharmacokinetic modelling of antibody-based drugs in children: Model development and population applications

Development of pharmacokinetic models for factor VIII and factor IX for use in individualization of dosing

Frequent collaborators

Alfonso Iorio

Joe Quadrilatero

Anil Maharaj

Anthony Chan

Davide Matino

David Lillicrap

Shinya Ito

Janusz Pawliszyn

Mark Minden

Mahla Poudineh

Mark McIntyre

Menaka Pai

Andrea Edginton

Research

Latest papers

Latest funding

Symptoms, Diagnosis, and Treatment for Women and Girls With Hemophilia: A Narrative Review

Country-level prediction of blood type distribution in hemophilia A in support of factor VIII consumption

Factor IX gene variants may influence the pharmacokinetic profile of patients with hemophilia B treated with FIX-Fc or N9-GP extended half-life FIX concentrates.

Defining Safe and Effective Cefazolin Dosing Regimens for MSSA Infections in the CNS: Leveraging Sparse Real-World Data and PBPK Modeling.

Physiologically Based Pharmacokinetic Modeling of Oxcarbazepine to Characterize Its Disposition in Children with Obesity.

Midazolam Dosing During CRRT: A Combined Ex&#xa0;Vivo and Physiologically-Based Pharmacokinetic Approach.

Transforming Treatment: The Impact of Bariatric Surgery on Oral Drug Absorption.

A Global Cross‐Sectional Database Study of Low Dose FVIII SHL Prophylaxis in Haemophilia A

Exploring the Impact of Laboratory Reagents on Pharmacokinetic Profiling

An Open-Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design.

Advancing neonatal exposure risk assessment to drug use during lactation using Physiologically-based pharmacokinetic modeling

A Bayesian inferential and extrapolation framework for in vivo exposure assessment following dermal application of sunscreens and cosmetics using state-of-the-art mechanistic PBPK models

Practical use of a novel clinical resource to address medication use during breastfeeding in the context of current practice

Targeting Neuroplasticity After Neonatal Brain Injury

Translating milk pharmacokinetic data into infant plasma level prediction: an application of population pharmacokinetics and infant physiologically-based population pharmacokinetic models to predict drug exposure to breastfeeding infants

Drugs in Breast Milk

PBTK modeling and simulation framework to identify critical data requirements for efficient and effective pediatric risk assessment

Use of population pharmacokinetics to improve safety and efficiency of hemophilia treatment

Physiologically-based pharmacokinetic modelling of antibody-based drugs in children: Model development and population applications

Development of pharmacokinetic models for factor VIII and factor IX for use in individualization of dosing

Frequent collaborators

Alfonso Iorio

Joe Quadrilatero

Anil Maharaj

Anthony Chan

Davide Matino

David Lillicrap

Shinya Ito

Janusz Pawliszyn

Mark Minden

Mahla Poudineh

Mark McIntyre

Menaka Pai

Midazolam Dosing During CRRT: A Combined Ex Vivo and Physiologically-Based Pharmacokinetic Approach.