Gianni Di Guglielmo, Western University

Research

Cell Migration Cellular Apoptosis Immunofluorescence Microscopy Non Small Cell Lung Cancer Polarity Complex Receptor Trafficking Transforming Growth Factor Beta

Latest papers

Acinar-specific loss of activating transcription factor 3 restricts KRASG12D mediated transcriptional changes and PanIN progression.
Cell death discovery · 2025

All 1 publications

Latest funding

Molecular mechanisms regulating lung development
NSERC · 2020 · Principal investigator
$160,000
Robotic Instrumentation to Establish Workflows for Systematic Cell-Based Analyses.
NSERC · 2017 · Co-investigator
$150,000
aPKC regulation of TGFß receptor trafficking and signaling in lung cancer cells.
CIHR · 2014 · Nominated PI
$679,462

All 7 grants and awards

1 publications.

01

Acinar-specific loss of activating transcription factor 3 restricts KRASG12D mediated transcriptional changes and PanIN progression.

Martin MB, Mousavi F, Goebel G, Di Stasi D, Mano A, Glogov A, Zhao L, Di Guglielmo G, Shooshtari P, Pin CL

Cell death discovery2025

DOI: 10.1038/s41420-025-02777-2 PMID: 41198649

Molecular mechanisms regulating lung development

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Di Guglielmo, Gianni

$160,000

Robotic Instrumentation to Establish Workflows for Systematic Cell-Based Analyses.

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Litchfield, David

$150,000

aPKC regulation of TGFß receptor trafficking and signaling in lung cancer cells.

Nominated PICIHR2014Operating Grant

Principal investigators: Di Guglielmo, Gianni (John) M

Keywords: Cell Migration; Cellular Apoptosis; Immunofluorescence Microscopy; Non Small Cell Lung Cancer; Polarity Complex; Receptor Trafficking; Transforming Growth Factor Beta

$679,462

Post-translational modifications of cytokines

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: DiGuglielmo, Gianni(John)

$130,000

Effects of Atypical Protein Kinase C Isoforms on Transforming Growth Factor Beta Signalling Pathways in Lung Cancer

SupervisorCIHR2010Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Gunaratne, Adrian D

Keywords: Cell Signalling Pathways; Epithelial To Mesenchymal Transition; Gene Expression; Immunofluorescence Microscopy; Lung Cancer; Metastasis; Molecular Biology; Protein Kinase C; Transforming Growth Factor Beta Signalling; Tumour Suppression

$105,000

TGFbeta receptor trafficking and signaling in lung cancer cells

Nominated PICIHR2008Operating Grant

Principal investigators: Di Guglielmo, Gianni (John) M

Keywords: Cell Motility; Migration And Invasion; Non-Small Cell Lung Cancer (Nsclc); Receptor Trafficking; Signal Transduction; Subcellular Fractionation

$633,015

The mechanism of TGFß receptor degradation via lipid rafts

Principal investigatorNSERC2006Discovery Grants Program - Individual

Principal investigators: DiGuglielmo, Gianni(John)

$170,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

PATHOLOGY & LABORATORY MEDICINE, Western University
Physiology and Pharmacology

Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Parisa Shooshtari

PATHOLOGY & LABORATORY MEDICINE, Western University

1 shared papers, latest 2025

Liena Zhao

PATHOLOGY & LABORATORY MEDICINE, Western University

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Mention their NSERC grant from 2020

Subject: Prospective PhD student: Cell Migration Dear Professor Di Guglielmo, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Acinar-specific loss of activating transcription factor 3 restricts KRASG12D mediated transcriptional changes and PanIN progression." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Molecular mechanisms regulating lung development" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]