Parisa Shooshtari

Research

Read how they describe their research on their Western University profile.

Cancer Associated Fibroblasts Chemotherapy Resistance Epigenetics Pancreatic Cancer Patient-Derived Organoids Single Cell Sequencing Tumour Microenvironment

Latest papers

B-cell subsets have different capacities for phagocytosis and subsequent presentation of antigen to cognate T cells.
Journal of immunology (Baltimore, Md. : 1950) · 2026
Viral mimicry acts as a tumor suppressor in colitis.
Nature communications · 2026
Developing a comprehensive database and search tool for single-cell ATAC-seq data.
Scientific reports · 2026 · senior author

All 15 publications

Latest funding

The Canadian Bioinformatics, Computational Biology and Health Data Sciences Training and Community Platform (BCBHDS Platform)
CIHR · 2024 · Co-investigator
$5,550,000
Detection of microRNAs in the conditioned culture medium as a non-invasive "miR-print" of human preimplantation embryo competence
CIHR · 2023 · Co-investigator
$719,100
Tumour cell reprogramming in pancreatic ductal adenocarcinoma as a means for therapeutic resistance
CIHR · 2022 · Principal investigator
$100,000

All 6 grants and awards

15 publications.

01

B-cell subsets have different capacities for phagocytosis and subsequent presentation of antigen to cognate T cells.

Morelli DM, Langille M, Zhang R, Craig HC, Eltom Mohamed A, Shooshtari P, Heit B, Kerfoot SM

Journal of immunology (Baltimore, Md. : 1950)2026

DOI: 10.1093/jimmun/vkaf282 PMID: 41082629

02

Viral mimicry acts as a tumor suppressor in colitis.

Larsen F, Jeong W, Schep D, Good HJ, Shin AE, Zhang L, Derouet MF, Wang TC, Castellani CA, Shooshtari P, Asfaha S

Nature communications2026

DOI: 10.1038/s41467-026-68850-1 PMID: 41639092

03

Developing a comprehensive database and search tool for single-cell ATAC-seq data.

Gibson-Khademi A, Wang J, Christensen E, Shooshtari P

Scientific reports2026Senior author

DOI: 10.1038/s41598-025-09962-4 PMID: 41545440

04

Acinar-specific loss of activating transcription factor 3 restricts KRASG12D mediated transcriptional changes and PanIN progression.

Martin MB, Mousavi F, Goebel G, Di Stasi D, Mano A, Glogov A, Zhao L, Di Guglielmo G, Shooshtari P, Pin CL

Cell death discovery2025

DOI: 10.1038/s41420-025-02777-2 PMID: 41198649

05

Mouse Models for Pancreatic Ductal Adenocarcinoma are Affected by the cre-driver Used to Promote KRASG12D Activation.

Mousavi F, Thompson J, Lau J, Renollet N, Martin MB, McGue J, Hassan O, Frankel T, Shooshtari P, Pin CL, Bednar F

Cellular and molecular gastroenterology and hepatology2025

DOI: 10.1016/j.jcmgh.2024.101428 PMID: 39547411

06

EZH2 deletion does not affect acinar regeneration but restricts progression to pancreatic cancer in mice.

Jaune-Pons E, Wang X, Mousavi F, Klassen Z, El Kaoutari A, Berger K, Johnson C, Martin MB, Aggarwal S, Brar S, Khalid M, Ryan JF, Shooshtari P, Mathison AJ, Dusetti N, Urrutia R, Lomberk G, Pin CL

JCI insight2024

DOI: 10.1172/jci.insight.173746 PMID: 39739419

07

Developing OCHROdb, a comprehensive quality checked database of open chromatin regions from sequencing data.

Shooshtari P, Feng S, Nelakuditi V, Asakereh R, Hosseini Naghavi N, Foong J, Brudno M, Cotsapas C

Scientific reports2023First author

DOI: 10.1038/s41598-022-26791-x PMID: 37202401

08

The EBV Gastric Cancer Resource (EBV-GCR): A Suite of Tools for Investigating EBV-Associated Human Gastric Carcinogenesis.

Salnikov MY, Wang E, Christensen E, Prusinkiewicz MA, Shooshtari P, Mymryk JS

Viruses2023

DOI: 10.3390/v15040853 PMID: 37112833

09

Evaluation of single-cell RNAseq labelling algorithms using cancer datasets.

Christensen E, Luo P, Turinsky A, Husić M, Mahalanabis A, Naidas A, Diaz-Mejia JJ, Brudno M, Pugh T, Ramani A, Shooshtari P

Briefings in bioinformatics2023Senior author

DOI: 10.1093/bib/bbac561 PMID: 36585784

10

Evaluation of single-cell RNA-seq clustering algorithms on cancer tumor datasets.

Mahalanabis A, Turinsky AL, Husić M, Christensen E, Luo P, Naidas A, Brudno M, Pugh T, Ramani AK, Shooshtari P

Computational and structural biotechnology journal2022Senior author

DOI: 10.1016/j.csbj.2022.10.029 PMID: 36420149

The Canadian Bioinformatics, Computational Biology and Health Data Sciences Training and Community Platform (BCBHDS Platform)

Co-investigatorCIHR2024Training Grant: HRTP - Bioinformatics, Computational Biology, Health Data Scien.

Principal investigators: Brazas, Michelle D; Bourque, Guillaume; Hsiao, William; Hughes, Nia; Hussin, Julie; Kong, Jude D; Pai, Shraddha; Sukhai, Mahadeo; Wasserman, Wyeth W; Wishart, David S

Keywords: Bioinformatics, Computational Biology & Health Data Science; Championing Diverse Talent And Careers; Competency Based Learning Pathways; Graduates, Post-Graduates And Early Career Researchers; Idea- And Career-Focused Matched Mentorship Guidance; Interdisciplinary, Intersectoral Capacity Building; Local Training Opportunities And Awards; National Community Building Activities; On-Demand, Virtual And In-Person Training; Professional Development Training

$5,550,000

Detection of microRNAs in the conditioned culture medium as a non-invasive "miR-print" of human preimplantation embryo competence

Co-investigatorCIHR2023Project Grant

Principal investigators: Betts, Dean H

Keywords: Aneuploidy; Developmental Competence; Extracellular Vesicles (Evs); Microrna; Non-Invasive Markers; Pluripotent Stem Cells; Pregnancy; Preimplantation Human Embryos; Synthetic Embryos ("Blastoids"); Trophoblast Stem Cells

$719,100

Tumour cell reprogramming in pancreatic ductal adenocarcinoma as a means for therapeutic resistance

Principal investigatorCIHR2022Project Grant - Priority Announcement: Cancer Research

Principal investigators: Pin, Christopher L; Shooshtari, Parisa

Keywords: Cancer Associated Fibroblasts; Chemotherapy Resistance; Epigenetics; Pancreatic Cancer; Patient-Derived Organoids; Single Cell Sequencing; Tumour Microenvironment

$100,000

Developing computational, statistical and machine learning methods to uncover biological mechanisms of complex phenotypes

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Shooshtari, Parisa

$96,000

Developing computational, statistical and machine learning methods to uncover biological mechanisms of complex phenotypes

Principal investigatorNSERC2021Discovery Launch Supplement

Principal investigators: Shooshtari, Parisa

$12,500

Mechanisms of driver mutation cooperativity in precursor B cell acute lymphoblastic leukemia

Co-investigatorCIHR2019Project Grant

Principal investigators: DeKoter, Rodney P

Keywords: B Cell Development; B Cell Leukemia; Gene Regulation; Janus Kinases; Reactive Oxygen Species; Transcription Factors

$929,475

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

PATHOLOGY & LABORATORY MEDICINE, Western University
Computer Science
Department of Medical Biophysics
Microbiology and Immunology
Physiology and Pharmacology
Medicine

Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Michael Brudno

Computer Science

4 shared papers, latest 2023

Trevor Pugh

Department of Medical Biophysics

2 shared papers, latest 2023

Liena Zhao

PATHOLOGY & LABORATORY MEDICINE, Western University

1 shared papers, latest 2025

Bryan Heit

Microbiology and Immunology

1 shared papers, latest 2026

Gianni Di Guglielmo

Physiology and Pharmacology

1 shared papers, latest 2025

Samuel Asfaha

Medicine

1 shared papers, latest 2026

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Cancer Associated Fibroblasts Dear Professor Shooshtari, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "B-cell subsets have different capacities for phagocytosis and subsequent presentation of antigen to cognate T cells." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Tumour cell reprogramming in pancreatic ductal adenocarcinoma as a means for therapeutic resistance" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]