Faculty profile
Haissi Cui
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Read how they describe their research on their University of Toronto profile.
Latest papers
Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis.
Science (New York, N.Y.) · 2026
A mutation in the nuclear speckle and splicing factor SRRM2 is associated with multisystem proteinopathy and causes dysregulation of synapse-associated genes.
RNA (New York, N.Y.) · 2026 · senior author
A call for unified use of human aminoacyl-tRNA synthetase (ARS) gene nomenclature.
FEBS letters · 2026
Latest funding
- $120,000
From genotype to phenotype: uncovering the cellular pathology of SRRM2 Gene mutations in neurodevelopmental disorders
CIHR · 2025 · Supervisor
- $210,000
High-dimensional, Single Cell Imaging Analysis to Understand the Role of Genetic Code Interpretation in Neurodevelopment and Degeneration
CIHR · 2024 · Supervisor
- $1,136,026
Nonviral Delivery of tRNA Therapeutics for Treating Cystic Fibrosis
CIHR · 2024 · Co-investigator
18 publications.
Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis.
Chen J, Zhou M, Dong S, Gong F, Tennakoon R, Seto BY, Chen ZR, Zhou ZP, Pan J, Xu Y, Luozhong S, Macarios CM, Tijaro-Bulla S, Gonska T, Hu J, Cui H, Li B
A mutation in the nuclear speckle and splicing factor SRRM2 is associated with multisystem proteinopathy and causes dysregulation of synapse-associated genes.
Shi Q, Lauder C, Miller JM, Wang YD, Elsakrmy N, Volkanoska S, Freibaum BD, Wuu J, Benatar M, Peng H, Kim HJ, Taylor JP, Cui H
A call for unified use of human aminoacyl-tRNA synthetase (ARS) gene nomenclature.
Antonellis A, Barrientos M, Bensasson E, DeClercq T, Garrigós P, Heilmann R, Horvath R, Magee D, Moresco A, Rowland A, Vallee I, Alexander R, Cui H, Gruić-Sovulj I, Hendrickson TL, Kim S, Ling J, Martinis SA, Musier-Forsyth K, Yang XL, Heinemann IU, Ribas de Pouplana L
Human aminoacyl-tRNA synthetases as integrators of translation and cell signalling networks.
Yoon I, Cui H, Kim S
Sialoglycan engineering empowered by recombinant sialyltransferases.
Woolcott SN, Da Barp I, Capicciotti CJ, Cui H, Edgar LJ
A disease-causing isoleucyl-tRNA synthetase variant leads to altered protein complex formation and cellular stress response.
Gao H, Tennakoon R, Araújo FP, Miller JM, Nyandwi SP, Shi Q, Padilla-Martínez JP, Peng H, Cui H
Sialoglycans on human T cells attenuate death programs executed through the Fas pathway.
Affe V, Lei Q, Veth TS, Sutherland E, Choksi H, Izzati FN, Shi Q, Cui H, Riley NM, Edgar LJ
Catalyzing computational biology research at an academic institute through an interest network.
Zak J, Newman I, Montiel Garcia DJ, Parisi D, Joy J, Head SR, Ducom JC, Natarajan P, Cui H, Ul-Hasan S
Presentation of immunoregulatory sialoglycans on T cells is divergent between mice and humans.
Izzati FN, Choksi H, Giuliana P, Abd-Rabbo D, Elsaesser H, Blundell A, Affe V, Kannen V, Jame-Chenarboo Z, Schmidt EN, Kuypers M, Avila DB, Chiu ESY, Badmaev D, Cui H, Matthews J, Mallevaey T, Macauley MS, Brooks DG, Edgar LJ
Non-viral mRNA delivery to the lungs.
Healy L, Seto BY, Cui H, Li B
From genotype to phenotype: uncovering the cellular pathology of SRRM2 Gene mutations in neurodevelopmental disorders
Principal investigators: Elsakrmy, Noha
Keywords: Intellectual Disability; Membraneless Organelles; Missense Mutations; Neurodevelopmental; Nuclear Speckles; Prime Editing; Rna; Spliceosome; Splicing; Tissue Culture
High-dimensional, Single Cell Imaging Analysis to Understand the Role of Genetic Code Interpretation in Neurodevelopment and Degeneration
Principal investigators: Bu, Yong Jia
Keywords: Cell Biology; Imaging; Mass Cytometry; Myelination; Neuroscience; Protein Synthesis; Single Cell Analysis; White Matter Disorders
Nonviral Delivery of tRNA Therapeutics for Treating Cystic Fibrosis
Principal investigators: Li, Bowen
Keywords: Cystic Fibrosis; Gene Therapy; Lipid Nanoparticles; Nonviral Gene Delivery; Rna Medicine; Trna Biology
Visualizing and Tracking Aminoacylation Reactions in Mammalian Cells
Principal investigators: Cui, Haissi
Uncovering the Role of RARS1 in Hypomyelinating Leukodystrophies
Principal investigators: Nyandwi, Samuel P
Keywords: Cell Biology; Enzyme Kinetics; Molecular Biology; Neurosciences; Pathogenesis; Rna; Trna Synthetases
Visualizing and Tracking Aminoacylation Reactions in Mammalian Cells
Principal investigators: Cui, Haissi
Keywords: nucleic acid; fluorescent probes; protein engineering; protein synthesis; synthetic biology; enzymes; rna engineering; cellular localization; proteins; microscopy
Combinatorial design of tRNA therapeutics for cystic fibrosis using patient-derived models
Principal investigators: LI, BOWEN
Exploring the molecular architecture of the human multisynthetase complex
Principal investigators: Cui, Haissi
Keywords: Aminoacyl-Trna Synthetase; Cancer Cell Signaling; Cellular Signaling; Cryo-Em; Genetic Code; Metabolism; Mrna Translation; Neurodevelopmental Disorder; Nucleic Acids; Trnas
Meeting on Aminoacyl-tRNA Synthetases 2023
Principal investigators: Heinemann, Ilka U; Cui, Haissi; O'Donoghue, Patrick
Keywords: Aminoacyl-Trna-Synthetase; Conference; Rna Therapeutics
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Yuzhuo Wang and Amina Zoubeidi: 17 shared papers
- Jim Hu and Tanja Gonska: 4 shared papers
- Gang Zheng and Bowen Li: 3 shared papers
- Yuzhuo Wang and Alejandro Berlin: 2 shared papers
- Jim Hu and Bowen Li: 2 shared papers
- Amina Zoubeidi and Alejandro Berlin: 2 shared papers
- Bowen Li and Haissi Cui: 2 shared papers
- Haissi Cui and Hui Peng: 2 shared papers
- Yuzhuo Wang and Brian Raught: 1 shared paper
- Yuzhuo Wang and Gang Zheng: 1 shared paper
- Yuzhuo Wang and Haissi Cui: 1 shared paper
- Jason Matthews and Thierry Mallevaey: 1 shared paper
- Jason Matthews and Haissi Cui: 1 shared paper
- Jim Hu and Haissi Cui: 1 shared paper
- Brian Raught and Gang Zheng: 1 shared paper
- Brian Raught and Amina Zoubeidi: 1 shared paper
- Brian Raught and Alejandro Berlin: 1 shared paper
- Brian Raught and Haissi Cui: 1 shared paper
- Thierry Mallevaey and Haissi Cui: 1 shared paper
- Gang Zheng and Haissi Cui: 1 shared paper
- Mark Nitz and Haissi Cui: 1 shared paper
- Amina Zoubeidi and Haissi Cui: 1 shared paper
- Alejandro Berlin and Haissi Cui: 1 shared paper
- Tanja Gonska and Bowen Li: 1 shared paper
- Tanja Gonska and Haissi Cui: 1 shared paper
- Department of Chemistry
- Department of Urologic Sciences
- Pharmaceutical Sciences
- Radiation Oncology/Medical Physics
- Research Institute
- Department of Pharmacology and Toxicology
- Genetics
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Hui Peng
Department of Chemistry
2 shared papers, latest 2026
Bowen Li
Pharmaceutical Sciences
2 shared papers, latest 2026
Jason Matthews
Department of Pharmacology and Toxicology
1 shared papers, latest 2025
Jim Hu
Genetics
1 shared papers, latest 2026
Brian Raught
Research Institute
1 shared papers, latest 2025
Thierry Mallevaey
Department of Immunology
1 shared papers, latest 2025
Yuzhuo Wang
Department of Urologic Sciences
1 shared papers, latest 2025
Mark Nitz
Department of Chemistry
1 shared papers, latest 2024
Amina Zoubeidi
Department of Urologic Sciences
1 shared papers, latest 2025
Alejandro Berlin
Radiation Oncology/Medical Physics
1 shared papers, latest 2025
Tanja Gonska
Faculty
1 shared papers, latest 2026
Gang Zheng
Faculty
1 shared papers, latest 2025
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Profile data last refreshed on September 26, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.