Faculty profile

Gang Zheng

ResearcherUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Gang Zheng

Researcher

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
56 publications in the last five years, latest in 2026.
Senior (last) author on 22 recent papers, a sign of leading a research group.
Principal investigator on 14 research grants (10 CIHR, 3 NSERC, 1 SSHRC), most recently in 2023.
Supervisor on 6 trainee awards (6 CIHR), most recently in 2021.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

204

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Drug Delivery Radiotherapy Microbubbles Photodynamic Therapy Bacterial Pneumonia Lung Surfactant Nanoemulsion Near-Infrared Light Delivery

Latest papers

From Morphology to Mechanism: Cryo-Electron Microscopy Insights into Lipid Nanoparticles for RNA Delivery.
ACS nano · 2026 · senior author
Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS.
Blood · 2026
Engineering Nanoemulsions to Maximize NIR-II Fluorescence and Preserve Photothermal Performance of a Novel Boron Difluoride Formazanate Dye.
Angewandte Chemie (International ed. in English) · 2026 · senior author

All 204 publications

Latest funding

New nanotechnology for non-invasive deep lung-activatable antimicrobial photodynamic therapy of hospital-associated pneumonia
CIHR · 2023 · Nominated PI
$837,676
Synergistic Radiosensitization of Hypoxic Pancreatic Adenocarcinoma using Gd-Texaphyrin Oxygen-Loaded Nanodroplets
CIHR · 2023 · Nominated PI
$994,500
A physiologically based pharmacokinetic modelling platform for predicting the clinical pharmacokinetics, pharmacodynamics, and toxicities of multifunctional theranostic nanoparticles in cancer patients
CIHR · 2021 · Supervisor
$105,000

All 33 grants and awards

From the 150 most recent of 204 publications.

From Morphology to Mechanism: Cryo-Electron Microscopy Insights into Lipid Nanoparticles for RNA Delivery.

Mo Y, Zheng G

ACS nano2026Senior author

DOI: 10.1021/acsnano.6c09354 PMID: 42438135

Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS.

Chen HTT, Joshi P, Cathelin S, Jahangiri S, Adeel SA, Xu J, Tsao E, Mo Y, Kealy D, Dowle A, Balde Z, Xuan M, Gowlett-Park D, Czibere K, Misura A, Bigun O, Sasso R, Lin A, Kundu N, Chadwick D, Usta S, Khazaee T, Chow S, Tsui H, Minden MD, Holding AN, Bridge KS, Zheng G, Hope KJ

Blood2026

DOI: 10.1182/blood.2025030731 PMID: 42322117

Engineering Nanoemulsions to Maximize NIR-II Fluorescence and Preserve Photothermal Performance of a Novel Boron Difluoride Formazanate Dye.

Kwon N, Buguis FL, Husby T, Chun S, Zhang D, Wu J, Rehl B, Ling B, Iqbal U, Washington M, Verner A, Huang K, Chen J, Gilroy JB, Zheng G

Angewandte Chemie (International ed. in English)2026Senior author

DOI: 10.1002/anie.4378015 PMID: 42080409

Dinuclear Ir(III)/Ru(II)/Os(II) Bis-terpyridine Complexes Tethered by Tetrathienyl-Substituted Diketopyrrolopyrrole: Synthesis, Photophysics, and Antimicrobial Photodynamic Therapy.

Sun X, Razzak M, Kassab G, Sun G, Gamage KD, Sivasubramanian M, Afrin H, Chen KH, Kilina S, Chen J, Zheng G, Lo LW, Sun W

Inorganic chemistry2026

DOI: 10.1021/acs.inorgchem.6c00600 PMID: 42686695

Porphyrin-lipid nanotheranostics for multimodal imaging of nodal disease in preclinical oral cancers.

Valic MS, Najjar E, Zheng M, Townson JL, Chan HHL, Tzelnick S, Ruaro A, El-Sayes A, Halim M, Schimmer P, Zhang CJ, Ye T, Jiang W, Chen J, Irish JC, Zheng G

Theranostics2026Senior author

DOI: 10.7150/thno.129853 PMID: 42370178

A novel auto-fluorescent porphyrin-lipid nanoparticle strategy for CTNNB1 gene silencing in hepatocellular carcinoma.

To JC, Apilan A, Pasini E, Mo Y, Chen J, Bakrania A, Bu J, Pan A, Adeyi O, Vogel A, Zheng G, Bhat M

Frontiers in oncology2026

DOI: 10.3389/fonc.2026.1779803 PMID: 42180053

A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery.

Zhou M, Xu Y, Li G, Chen J, Savguira M, Seto B, Gong F, Thomson T, Chen J, Lu RXZ, Dong S, Chen D, Eileen C, Wu S, Zheng G, Li B

Nature biotechnology2026

DOI: 10.1038/s41587-026-03109-0 PMID: 42050330

Advancing regenerative medicine with RNA nanotechnology for chronic and end organ diseases.

Bakrania A, Nguyen Lefebvre AT, de Vries R, Laflamme MA, Jaeckel E, Hansen He H, Radvanyi L, Hedtrich S, Sahay G, Blakney A, Sefton M, Li B, Zheng G, Bhat M

Communications medicine2026

DOI: 10.1038/s43856-026-01476-y PMID: 41965828

Structural Change of ApoE-Lipid Nanoparticles Alters Receptor-Mediated Endocytosis and Induces Endosomal Disruption.

Mo Y, Liu H, Keszei AFA, Dai DL, Makky A, Ding L, Pan A, Bu J, Mazhab-Jafari MT, Chen J, Zheng G

Journal of the American Chemical Society2026Senior author

DOI: 10.1021/jacs.5c16025 PMID: 41711348

A Membrane Fluidization Strategy Significantly Boosts Photodynamic Therapy and Antitumor Immunity of Porphyrin-Lipid Nanoparticles.

Ho T, Valic M, Liu TW, Zheng M, Yang Y, Guidolin K, Ding L, Mo Y, Qian A, Kwon N, Pires L, Wilson BC, Makky A, Chen J, Zheng G

ACS nano medicine2026Senior author

DOI: 10.1021/acsnanomed.5c00053 PMID: 41695020

New nanotechnology for non-invasive deep lung-activatable antimicrobial photodynamic therapy of hospital-associated pneumonia

Nominated PICIHR2023Project Grant

Principal investigators: Zheng, Gang

Keywords: Bacterial Pneumonia; Lung Surfactant; Nanoemulsion; Near-Infrared Light Delivery; Photosensitizers; Targeted Respiratory Delivery

$837,676

Synergistic Radiosensitization of Hypoxic Pancreatic Adenocarcinoma using Gd-Texaphyrin Oxygen-Loaded Nanodroplets

Nominated PICIHR2023Project Grant

Principal investigators: Zheng, Gang; Koritzinsky, Marianne

Keywords: Desmoplasia; Drug Delivery; Focused Ultrasound; Patient-Derived Cancer Model; Phase-Shift Droplets; Radiotherapy; Tumor Microenvironment

$994,500

A physiologically based pharmacokinetic modelling platform for predicting the clinical pharmacokinetics, pharmacodynamics, and toxicities of multifunctional theranostic nanoparticles in cancer patients

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Valic, Michael S

Keywords: Clinical Simulation; Model Validation; Nanotechnology; Pharmacodynamics; Pharmacokinetic Modelling; Pharmacokinetics; Phase 1 Clinical Trial; Tumour Models

$105,000

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Keshavjee, Shaf

Keywords: Immunology; Immunotolerance; Organ transplantation; Ex vivo organ perfusion; Gene modification; Cell therapy; Translational research; Organ repair; Medical ethics; Biomedical engineering; Patient-centred approach; Precision medicine

$8,000,000

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Keshavjee, Shaf

Keywords: Immunology Immunotolerance Organ transplantation Ex vivo organ perfusion Gene modification Cell therapy Translational research Organ repair Medical ethics Biomedical engineering Patient-centred approach Precision medicine

$8,000,000

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Crudden, Cathleen

Keywords: Surface Science Nanomedicine Corrosion protection Nanomaterials Self Assembled Monolayers N-heterocyclic Carbenes Bio-Imaging

$8,000,000

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Crudden, Cathleen

Keywords: Surface Science; Nanomedicine; Corrosion protection; Nanomaterials; Self Assembled Monolayers; N-heterocyclic Carbenes; Bio-Imaging

$8,000,000

Developing porphysome nanomedicines for applications in colorectal cancer

SupervisorCIHR2020Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Guidolin, Keegan

Keywords: Cancer Nanomedicine

$105,000

Express delivery of RNA therapeutics to cancer

Principal investigatorSSHRC2020New Frontiers in Research Fund - Exploration

Principal investigators: Zheng, Gang

$250,000

Canada Research Chair - Tier 1

Nominated PICIHR2018Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Zheng, Gang

Keywords: Crc

$1,400,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Gang Zheng

Research

Latest papers

Latest funding

From Morphology to Mechanism: Cryo-Electron Microscopy Insights into Lipid Nanoparticles for RNA Delivery.

Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS.

Engineering Nanoemulsions to Maximize NIR-II Fluorescence and Preserve Photothermal Performance of a Novel Boron Difluoride Formazanate Dye.

Dinuclear Ir(III)/Ru(II)/Os(II) Bis-terpyridine Complexes Tethered by Tetrathienyl-Substituted Diketopyrrolopyrrole: Synthesis, Photophysics, and Antimicrobial Photodynamic Therapy.

Porphyrin-lipid nanotheranostics for multimodal imaging of nodal disease in preclinical oral cancers.

A novel auto-fluorescent porphyrin-lipid nanoparticle strategy for CTNNB1 gene silencing in hepatocellular carcinoma.

A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery.

Advancing regenerative medicine with RNA nanotechnology for chronic and end organ diseases.

Structural Change of ApoE-Lipid Nanoparticles Alters Receptor-Mediated Endocytosis and Induces Endosomal Disruption.

A Membrane Fluidization Strategy Significantly Boosts Photodynamic Therapy and Antitumor Immunity of Porphyrin-Lipid Nanoparticles.

New nanotechnology for non-invasive deep lung-activatable antimicrobial photodynamic therapy of hospital-associated pneumonia

Synergistic Radiosensitization of Hypoxic Pancreatic Adenocarcinoma using Gd-Texaphyrin Oxygen-Loaded Nanodroplets

A physiologically based pharmacokinetic modelling platform for predicting the clinical pharmacokinetics, pharmacodynamics, and toxicities of multifunctional theranostic nanoparticles in cancer patients

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Developing porphysome nanomedicines for applications in colorectal cancer

Express delivery of RNA therapeutics to cancer

Canada Research Chair - Tier 1

Frequent collaborators

Kazuhiro Yasufuku

Mamatha Bhat

Robert Weersink

Bowen Li

Shaf Keshavjee

Robert Harrison

Marianne Koritzinsky

Catherine Coolens

Margarete Akens

Michael Sefton

Kullervo Hynynen

Slava Epelman

David Goertz

Mohit Kapoor

David Hwang

Amina Zoubeidi

Tracy McGaha

Sarah Hedtrich

Alejandro Berlin

BO WANG

Anna Blakney

Robert Rottapel

Rama Khokha

David Jaffray

Mingyao Liu

David Malkin

Brian Raught

Catherine O'Brien

Ren-Ke Li

Yuzhuo Wang

Anna Goldenberg