Faculty profile
Karel Tyml
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Read how they describe their research on their Western University profile.
Latest papers
Vitamin C and Microvascular Dysfunction in Systemic Inflammation.
Antioxidants (Basel, Switzerland) · 2017 · first author
Ascorbate inhibits platelet-endothelial adhesion in an in-vitro model of sepsis via reduced endothelial surface P-selectin expression.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2017 · senior author
Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice.
Critical care (London, England) · 2017 · first author
Latest funding
- $642,828
A Systems Approach to Sepsis: Pathological versus Adaptive Microvascular Responses
CIHR · 2009 · Co-investigator
25 publications.
Vitamin C and Microvascular Dysfunction in Systemic Inflammation.
Tyml K
Ascorbate inhibits platelet-endothelial adhesion in an in-vitro model of sepsis via reduced endothelial surface P-selectin expression.
Secor D, Swarbreck S, Ellis CG, Sharpe MD, Feng Q, Tyml K
Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice.
Tyml K, Swarbreck S, Pape C, Secor D, Koropatnick J, Feng Q, Veldhuizen RAW, Gill SE
Effect of ascorbate on plasminogen activator inhibitor-1 expression and release from platelets and endothelial cells in an in-vitro model of sepsis.
Swarbreck SB, Secor D, Ellis CG, Sharpe MD, Wilson JX, Tyml K
Critical Role of Cx40 in Reduced Endothelial Electrical Coupling by Lipopolysaccharide and Hypoxia-Reoxygenation.
Siddiqui M, Swarbreck S, Shao Q, Secor D, Peng T, Laird DW, Tyml K
Short-term effect of ascorbate on bacterial content, plasminogen activator inhibitor-1, and myeloperoxidase in septic mice.
Swarbreck SB, Secor D, Ellis CG, Sharpe MD, Wilson JX, Tyml K
Effect of ascorbate on fibrinolytic factors in septic mouse skeletal muscle
Swarbreck S, Secor D, Li F, Gross PL, Ellis CG, Sharpe MD, Wilson JX, Tyml K
Ascorbate reduces mouse platelet aggregation and surface P-selectin expression in an ex vivo model of sepsis.
Secor D, Swarbreck S, Ellis CG, Sharpe MD, Tyml K
Atrial tachycardia/fibrillation in the connexin 43 G60S mutant (Oculodentodigital dysplasia) mouse.
Tuomi JM, Tyml K, Jones DL
Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis.
Tyml K
A Systems Approach to Sepsis: Pathological versus Adaptive Microvascular Responses
Principal investigators: Ellis, Christopher G
Keywords: Intravital Video Microscopy; Mathematical Modeling; Microvascular Oxygen Transport; Sepsis; Spectrophotometry; Tissue Oxygenation
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Department of Medical Biophysics
- Physiology and Pharmacology
- Pathology and Laboratory Medicine
- Medicine
- Other
Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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Profile data last refreshed on November 9, 2025 from the university directory, publication records and CIHR, NSERC and SSHRC funding.