Rithwik Ramachandran

Research

Read how they describe their research on their Western University profile.

Proteinase Activated Receptors Cell Signalling G-Protein Coupled Receptors Platelets Thrombin Thrombosis Fibrosis Gpcr

Latest papers

Urea-based lysophosphatidic acid receptor 1 antagonists as potential migrastatics for triple-negative breast cancer.
Bioorganic chemistry · 2026
Defining the interactome of the pancreas-specific SPCA2 isoform (SPCA2C) identifies unique links to store-operated Ca2+ entry.
The FEBS journal · 2025
Lysophosphatidic Acid Receptor 1 (LPA1) Antagonists as Potential Migrastatics for Triple Negative Breast Cancer.
ChemMedChem · 2024

All 29 publications

Latest funding

Proteinase Activated Receptor (PAR) regulation of YAP/TAZ signaling in liver disease
CIHR · 2025 · Nominated PI
$1,013,625
Developing Tough, Elastomeric, Bioactive Hydrogel Dressings to Accelerate in situ Bone Repair
CIHR · 2025 · Co-investigator
$830,025
Developing Tough, Elastomeric, Bioactive Hydrogel Dressings to Accelerate in situ Bone Repair
CIHR · 2022 · Co-investigator
$100,000

All 9 grants and awards

29 publications.

01

Urea-based lysophosphatidic acid receptor 1 antagonists as potential migrastatics for triple-negative breast cancer.

Liu W, Mousa AAK, Dayer G, Hopkins AM, Campbell M, Mao Y, Jiang ZH, Lees SJ, Ramachandran R, Hou J

Bioorganic chemistry2026

DOI: 10.1016/j.bioorg.2026.109807 PMID: 41911633

02

Defining the interactome of the pancreas-specific SPCA2 isoform (SPCA2C) identifies unique links to store-operated Ca2+ entry.

Samardzija P, Fenech MA, Hassan O, Lang R, Carter MC, Chen S, Shi S, Ramachandran R, Stathopulos PB, Pin CL

The FEBS journal2025

DOI: 10.1111/febs.70213 PMID: 40783819

03

Lysophosphatidic Acid Receptor 1 (LPA1) Antagonists as Potential Migrastatics for Triple Negative Breast Cancer.

Liu W, Mousa AAK, Hopkins AM, Wu YF, Thu KL, Campbell M, Lees SJ, Ramachandran R, Hou J

ChemMedChem2024

DOI: 10.1002/cmdc.202400013 PMID: 38648251

04

Transient receptor potential vanilloid 4 regulates extracellular matrix composition and mediates load-induced intervertebral disc degeneration in a mouse model.

Mark Kim MK, Lawrence M, Quinonez D, Brooks C, Ramachandran R, Séguin CA

Osteoarthritis and cartilage2024

DOI: 10.1016/j.joca.2024.04.001 PMID: 38604493

05

A survey of stapling methods to increase affinity, activity, and stability of ghrelin analogues.

Esteban JJ, Mason JR, Kaminski J, Ramachandran R, Luyt LG

RSC medicinal chemistry2024

DOI: 10.1039/d3md00441d PMID: 38283230

06

Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells.

Chandrabalan A, Ramachandran R

American journal of physiology. Cell physiology2023Senior author

DOI: 10.1152/ajpcell.00382.2022 PMID: 37273236

07

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.

Deng L, Costa F, Blake KJ, Choi S, Chandrabalan A, Yousuf MS, Shiers S, Dubreuil D, Vega-Mendoza D, Rolland C, Deraison C, Voisin T, Bagood MD, Wesemann L, Frey AM, Palumbo JS, Wainger BJ, Gallo RL, Leyva-Castillo JM, Vergnolle N, Price TJ, Ramachandran R, Horswill AR, Chiu IM

Cell2023

DOI: 10.1016/j.cell.2023.10.019 PMID: 37995657

08

Protease-activated receptor 2 (PAR2)-targeting peptide derivatives for positron emission tomography (PET) imaging.

LeSarge JC, Thibeault P, Yu L, Childs MD, Mirka VM, Qi Q, Fox MS, Kovacs MS, Ramachandran R, Luyt LG

European journal of medicinal chemistry2023

DOI: 10.1016/j.ejmech.2022.114989 PMID: 36527934

09

Discovery of Ghrelin(1-8) Analogues with Improved Stability and Functional Activity for PET Imaging.

Childs MD, Chandrabalan A, Hodgson D, Ramachandran R, Luyt LG

ACS pharmacology & translational science2023

DOI: 10.1021/acsptsci.3c00088 PMID: 37470019

10

Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling.

Chandrabalan A, Firth A, Litchfield RB, Appleton CT, Getgood A, Ramachandran R

Scientific reports2023Senior author

DOI: 10.1038/s41598-023-28068-3 PMID: 36670151

Proteinase Activated Receptor (PAR) regulation of YAP/TAZ signaling in liver disease

Nominated PICIHR2025Project Grant

Principal investigators: Ramachandran, Rithwik

Keywords: Fibrosis; Gpcr; Liver; Masld; Proteinase Activated Receptor; Yap/Taz

$1,013,625

Developing Tough, Elastomeric, Bioactive Hydrogel Dressings to Accelerate in situ Bone Repair

Co-investigatorCIHR2025Project Grant

Principal investigators: Paul, Arghya

Keywords: Biomaterials; Bone Repair; Drug Delivery Systems; Hydrogel; Nanomedicine; Nanoparticles; Polymers; Regenerative Medicine; Tissue Repair; Wound Healing

$830,025

Developing Tough, Elastomeric, Bioactive Hydrogel Dressings to Accelerate in situ Bone Repair

Co-investigatorCIHR2022Pro. Gr. - PA: Inst. of Musculoskeletal Health and Arthritis: IMHA Mandate Areas

Principal investigators: Paul, Arghya

Keywords: Biomaterial; Drug Delivery Systems; Growth Factors; Hydrogels; Nanomedicine; Nanoparticles; Polymers; Regenerative Medicine; Stem Cells; Wound Healing

$100,000

Vascular endothelium-specific PAR2: mechanisms and effects

Co-investigatorCIHR2022Project Grant

Principal investigators: McGuire, John J

Keywords: Blood Pressure; Blood Vessel; Endothelial Cell-Specific Knockout Mouse; Peptides; Protease-Activated Receptor 2; Vascular Endothelium

$975,376

Targeting the Protease Activated Receptor (PAR) - Transient Receptor Potential Vanilloid-4 (TRPV4) signalling axis in osteoarthritis.

Nominated PICIHR2021Project Grant

Principal investigators: Ramachandran, Rithwik

Keywords: Animal Models; Inflammation; Mechanosensitive Ion Channels; Osteoarthritis; Pain; Proteinase Activated Receptors; Proteolytic Enzymes; Synovial Fluids; Therapeutic Targets; Trpv4

$711,450

Microscale thermophoresis for assessing diverse molecular interactions.

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Stathopulos, Peter

$150,000

Subcellular organization of Adhesion G-Protein Coupled Receptor (aGPCR) signalling.

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Ramachandran, Rithwik

$192,000

Dissecting Proteinase Activated Receptor-4 (PAR4) signaling in the cardiovascular system.

Nominated PICIHR2016Project Grant

Principal investigators: Ramachandran, Rithwik

Keywords: Cell Signalling; G-Protein Coupled Receptors; Platelets; Proteinase Activated Receptors; Thrombin; Thrombosis

$401,625

Dissecting Proteinase Activated Receptor-4 signaling in the cardiovascular system

Nominated PICIHR2016Project Grant

Principal investigators: Ramachandran, Rithwik

Keywords: Cell Signalling; G-Protein Coupled Receptors; Platelets; Proteinase Activated Receptors; Thrombin; Thrombosis

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Department of Physiology and Pharmacology
Biochemistry & Biomedical Sciences
Physiology and Pharmacology
Department of Surgery
Department of Medical Biophysics
Other

1 shared papers, latest 2020

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Proteinase Activated Receptors Dear Professor Ramachandran, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Urea-based lysophosphatidic acid receptor 1 antagonists as potential migrastatics for triple-negative breast cancer." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Proteinase Activated Receptor (PAR) regulation of YAP/TAZ signaling in liver disease" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Rithwik Ramachandran

Research

Latest papers

Latest funding

Urea-based lysophosphatidic acid receptor 1 antagonists as potential migrastatics for triple-negative breast cancer.

Defining the interactome of the pancreas-specific SPCA2&#xa0;isoform (SPCA2C) identifies unique links to store-operated Ca2+ entry.

Lysophosphatidic Acid Receptor 1 (LPA1) Antagonists as Potential Migrastatics for Triple Negative Breast Cancer.

Transient receptor potential vanilloid 4 regulates extracellular matrix composition and mediates load-induced intervertebral disc degeneration in a mouse model.

A survey of stapling methods to increase affinity, activity, and stability of ghrelin analogues.

Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells.

S.&#xa0;aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.

Protease-activated receptor 2 (PAR2)-targeting peptide derivatives for positron emission tomography (PET) imaging.

Discovery of Ghrelin(1-8) Analogues with Improved Stability and Functional Activity for PET Imaging.

Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling.

Proteinase Activated Receptor (PAR) regulation of YAP/TAZ signaling in liver disease

Developing Tough, Elastomeric, Bioactive Hydrogel Dressings to Accelerate in situ Bone Repair

Developing Tough, Elastomeric, Bioactive Hydrogel Dressings to Accelerate in situ Bone Repair

Vascular endothelium-specific PAR2: mechanisms and effects

Targeting the Protease Activated Receptor (PAR) - Transient Receptor Potential Vanilloid-4 (TRPV4) signalling axis in osteoarthritis.

Microscale thermophoresis for assessing diverse molecular interactions.

Subcellular organization of Adhesion G-Protein Coupled Receptor (aGPCR) signalling.

Dissecting Proteinase Activated Receptor-4 (PAR4) signaling in the cardiovascular system.

Dissecting Proteinase Activated Receptor-4 signaling in the cardiovascular system

Frequent collaborators

Christophe Altier

Alan Getgood

Jeffrey Weitz

Bernardo Trigatti

Elena Verdu

Gail Gauvreau

Premysl Bercik

Roma Sehmi

Alberto Caminero Fernandez

Peter Lawrence Gross

Heather Galipeau

Tuan Trang

Savita Dhanvantari

Peter Chidiac

Jonathan Schertzer

Robert Gros

Defining the interactome of the pancreas-specific SPCA2 isoform (SPCA2C) identifies unique links to store-operated Ca2+ entry.

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.