Faculty profile

Christophe Altier

ResearcherPhysiology and PharmacologyUniversity of Calgary

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Calgary directory, so their courses may be missing. Find their university profile.

Christophe Altier

Researcher

Physiology and Pharmacology

Health Sciences

University of Calgary

Calgary, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
20 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (7 CIHR, 1 NSERC), most recently in 2025.
Supervised 2 trainees who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

422

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Electrophysiology Inflammation Pain Dorsal Root Ganglia Ion Channels Behavior Molecular Biology Cell Signaling

Latest papers

Wired for immunity: neuroimmune control of the lung by sensory neurons.
Nature reviews. Neuroscience · 2026
Skin inflammation and itch response are independently regulated by distinct nociceptor subsets.
Immunity · 2026
Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents.
Neuron · 2026

All 72 publications

Latest funding

The regulation of intestinal first-pass metabolism by IL-22 - understanding the link between host-microbe/pathogen interactions and alterations in drug metabolism.
CIHR · 2025 · Co-investigator
$1,263,780
ALKAL2-ALK signaling in spontaneous neuropathic pain
CIHR · 2025 · Nominated PI
$1,021,276
Immune and sensory modulation of fibroblast function during skin regeneration
CIHR · 2023 · Co-investigator
$875,926

All 16 grants and awards

72 publications.

Wired for immunity: neuroimmune control of the lung by sensory neurons.

Ehlers AM, Guerrero-Fonseca IM, Altier C, Yipp BG, Talbot S

Nature reviews. Neuroscience2026

DOI: 10.1038/s41583-026-01046-0 PMID: 42062471

Skin inflammation and itch response are independently regulated by distinct nociceptor subsets.

Voisin T, Gheziel N, El Samrout C, Martin J, Bradaia A, Iftinca M, Defaye M, Charron A, Abdullah NS, Changenot C, Gonzalez AA, Depluech A, Labit E, Saint-Laurent N, Staurengo-Ferrari L, Erdogan O, Tauber M, Loste A, Serhan N, Villa-Hernandez S, Chiu IM, Moqrich A, Altier C, Basso L, Gaudenzio N

Immunity2026

DOI: 10.1016/j.immuni.2026.03.020 PMID: 41990747

Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents.

Leduc-Pessah H, McAllister BB, Sinha S, Stokes-Heck S, Nishizawa D, Fan CY, St-Pierre MK, Bradaia A, Defaye M, Burma NE, Damblon J, Muñoz-Pino E, Visser F, Dorion MF, Healy LM, Tang YM, Canet-Pons J, van den Hoogen NJ, Zhang Z, Antunes FTT, Piscopo VEC, Medina M, Fukuda KI, Ichinohe T, Nagashima M, Hayashida M, Johnson E, Agrawal A, Degenhardt L, Martin NG, Zamponi GW, Nelson EC, Altier C, Tremblay ME, Bousman C, Stifani S, De Koninck Y, Ikeda K, Biernaskie J, Trang T

Neuron2026

DOI: 10.1016/j.neuron.2025.11.018 PMID: 41619726

Mechanisms of chronic abdominal pain in inflammatory bowel disease and implications for treatment.

Defaye M, Nasser Y, Altier C

Nature reviews. Gastroenterology & hepatology2026Senior author

DOI: 10.1038/s41575-025-01139-8 PMID: 41339763

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis.

Hiroki CH, Hassanabad MF, Defaye M, Sarden N, Bartlett A, Farias R, Nguyen AP, Guerrero-Fonseca IM, Yoon G, Brown L, Ma C, Yang H, Belke D, Fatehi Hassanabad A, McCoy C, Rosin NL, Orton DJ, Fedak PWM, Vallance BA, Yu H, Jacobson K, Khan N, Altier C, Kelly MM, Yipp BG

Immunity2025

DOI: 10.1016/j.immuni.2025.05.002 PMID: 40449484

The gut microbiota promotes pain in fibromyalgia.

Cai W, Haddad M, Haddad R, Kesten I, Hoffman T, Laan R, Westfall S, Defaye M, Abdullah NS, Wong C, Brown N, Tansley S, Lister KC, Hooshmandi M, Wang F, Lorenzo LE, Hovhannisyan V, Ho-Tieng D, Kumar V, Sharif B, Thurairajah B, Fan J, Sahar T, Clayton C, Wu N, Zhang J, Bar-Yoseph H, Pitashny M, Krock E, Mogil JS, Prager-Khoutorsky M, Séguéla P, Altier C, King IL, De Koninck Y, Brereton NJB, Gonzalez E, Shir Y, Minerbi A, Khoutorsky A

Neuron2025

DOI: 10.1016/j.neuron.2025.03.032 PMID: 40280127

Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer.

Delanne-Cuménal M, Defaye M, Delanne-Cuménal A, Ahmed M, Ho V, Abdullah NS, Alhassoun M, Svendsen K, Mager L, Schlessinger J, Hirota S, Altier C

Proceedings of the National Academy of Sciences of the United States of America2025Senior author

DOI: 10.1073/pnas.2500632122 PMID: 40493183

Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells.

Abdullah NS, Bradaia A, Defaye M, Ohland C, Svendsen K, Dickemann A, Delanne-Cumenal M, Hassan A, Iftinca M, McCoy KD, Altier C

Mucosal immunology2025Senior author

DOI: 10.1016/j.mucimm.2024.12.002 PMID: 39662673

Uncovering the therapeutic potential of anti-tuberculoid agent Isoniazid in a model of microbial-driven Crohn's disease.

Stephens M, Keane K, Roizes S, Defaye M, Altier C, von der Weid PY

Journal of Crohn's & colitis2025

DOI: 10.1093/ecco-jcc/jjaf032 PMID: 39987456

Entourage effects of nonpsychotropic cannabinoids on visceral sensitivity in experimental colitis.

Svendsen K, Bradaia A, Gandini MA, Defaye M, Matisz C, Abdullah NS, Gruber A, Zamponi GW, Sharkey KA, Altier C

The Journal of pharmacology and experimental therapeutics2025Senior author

DOI: 10.1016/j.jpet.2025.103389 PMID: 39921943

The regulation of intestinal first-pass metabolism by IL-22 - understanding the link between host-microbe/pathogen interactions and alterations in drug metabolism.

Co-investigatorCIHR2025Project Grant

Principal investigators: Hirota, Simon A

Keywords: Cell Differentiation; Cytochrome P450; Drug Metabolism; Host-Microbe Interactions; Il-22; Innate Lymphoid Cells; Intestinal Epithelium; Intestinal Organoids; Intestinal Stem Cells

$1,263,780

ALKAL2-ALK signaling in spontaneous neuropathic pain

Nominated PICIHR2025Project Grant

Principal investigators: Altier, Christophe

Keywords: Cell Signaling; Electrophysiology; Neurons; Neuropathic Pain; Tyrosine Kinase Receptors

$1,021,276

Immune and sensory modulation of fibroblast function during skin regeneration

Co-investigatorCIHR2023Project Grant

Principal investigators: Biernaskie, Jeffrey A

Keywords: Scar; Sensory Innervation; Single Cell Genomics; Skin Regeneration; Stromal-Immune Interactions; Wound Healing

$875,926

The gut microbiome controls chronic post-inflammatory pain via STING

SupervisorCIHR2023CIHR Fellowship

Principal investigators: Defaye, Manon E

Keywords: Behavior; Inflammation; Interferons; Microbiome; Sting; Trp Channels; Viceral Pain

$135,000

Interferon-Stimulated Genes and pain sensitivity

Nominated PICIHR2022Project Grant

Principal investigators: Altier, Christophe

Keywords: Behavior; Dorsal Root Ganglia; Electrophysiology; Inflammation; Interferons; Ion Channels; Pain; Sting

$986,850

Neuro-immune control of postoperative pain via CCL22:CCR4 signaling

Co-investigatorCIHR2020Project Grant

Principal investigators: Ghasemlou, Nader

Keywords: Behavioural Assays; Cytokines; Dendritic Cells; Electrophysiology; Immunology; Neuroinflammation; Neuroscience; Pain

$937,126

The role of the microbiome in chronic visceral pain in inflammatory bowel disease

Co-investigatorCIHR2020Project Grant

Principal investigators: Nasser, Yasmin

Keywords: Calcium Imaging; Chronic Pain; Dss Colitis; Electrophysiology; Inflammatory Bowel Disease; Metabolome; Microbiome; Short Chain Fatty Acids; Trpv1

$772,650

Kananaskis Inflammation Workshop 2020

Nominated PICIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Altier, Christophe

Keywords: Digestive System; Host-Parasite Interaction; Immunology; Infectious Diseases; Inflammation; Microbiome; Opioids; Pain; Pathophysiology; Pharmacology

$10,000

Lung Sensory Nerves Detect Pathogens and Alter Pneumonia Outcomes via the Regulation of Neutrophils

Co-investigatorCIHR2018Project Grant

Principal investigators: Yipp, Bryan

Keywords: Chronic Lung Disease; Endothelium; Host-Pathogen Interaction; Neuroimmune; Neutrophils; Pneumonia; Pulmonary Inflammation

$914,176

Regulation of opioid analgesia by the TRPV1 channel

Nominated PICIHR2017Project Grant

Principal investigators: Altier, Christophe

Keywords: Behavior; Dorsal Root Ganglia; Electrophysiology; Inflammation; Ion Channels; Molecular Biology; Opioid Receptors; Pain; Signaling Pathway; Trp Channels

$975,375

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Christophe Altier

Research

Latest papers

Latest funding

Wired for immunity: neuroimmune control of the lung by sensory neurons.

Skin inflammation and itch response are independently regulated by distinct nociceptor subsets.

Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents.

Mechanisms of chronic abdominal pain in inflammatory bowel disease and implications for treatment.

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis.

The gut microbiota promotes pain in fibromyalgia.

Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer.

Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells.

Uncovering the therapeutic potential of anti-tuberculoid agent Isoniazid in a model of microbial-driven Crohn's disease.

Entourage effects of nonpsychotropic cannabinoids on visceral sensitivity in experimental colitis.

Frequent collaborators

Tuan Trang

Yasmin Nasser

Houman Khosravani

Rithwik Ramachandran

Haitao You

Yves De Koninck

Pierre-Yves Von Der Weid

Gerald Zamponi

Roger Thompson

Simon Hirota

Ian Gilron

Nader Ghasemlou

Masha Prager-Khoutorsky

Ji Zhang

Arkady Khoutorsky

Antoine Dufour

Yves De Koninck

Marie-Ève Tremblay

Chad Bousman

Nargis Khan

Sébastien Talbot