Faculty profile

Zhu-Xu Zhang

ResearcherMedicineWestern University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Western University directory, so their courses may be missing. Find their university profile.

Zhu-Xu Zhang

Researcher

Medicine

Health Sciences

Western University

London, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
7 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 3 research grants (3 CIHR), most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Read how they describe their research on their Western University profile.

Apoptosis Injury Necroptosis Transplantation Damage Associated Molecular Patterns Endothelial Cell Heart Ischemia-Reperfusion Injury

Latest papers

Adenosine deaminase acting on RNA 1 and receptor-interacting serine/threonine-protein kinase-1 orchestrate the Z-DNA-binding protein 1-mediated PANoptosis and mouse heart transplant rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026 · senior author
Corrigendum to "Adenosine deaminase acting on RNA 1 and receptor-interacting serine/threonine-protein kinase-1 orchestrate the Z-DNA-binding protein 1-mediated PANoptosis and mouse heart transplant rejection" [American Journal of Transplantation Volume 26, Issue 5, May 2026, Pages 962-979].
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026 · senior author
Nicotinamide mononucleotide protects septic hearts in mice via preventing cyclophilin F modification and lysosomal dysfunction.
Acta pharmacologica Sinica · 2025

All 38 publications

Latest funding

TLR3 is an endogenous sensor of cell death and a potential target for induction of long-term heart transplant survival
CIHR · 2019 · Nominated PI
$550,800
Characterization of endothelial cell death biomarkers for better prediction and prevention of renal fibrosis triggered by acute kidney injury
CIHR · 2017 · Co-investigator
$707,625
Regulation of pretransplant ischemic injury and cardiac allograft vasculopathy
CIHR · 2014 · Nominated PI
$100,000

All 6 grants and awards

38 publications.

Adenosine deaminase acting on RNA 1 and receptor-interacting serine/threonine-protein kinase-1 orchestrate the Z-DNA-binding protein 1-mediated PANoptosis and mouse heart transplant rejection.

Lu H, Jiang J, Huang X, Peng T, Haig A, Jevnikar AM, Gunaratnam L, Zhang ZX

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026Senior author

DOI: 10.1016/j.ajt.2026.02.003 PMID: 41692363

Corrigendum to "Adenosine deaminase acting on RNA 1 and receptor-interacting serine/threonine-protein kinase-1 orchestrate the Z-DNA-binding protein 1-mediated PANoptosis and mouse heart transplant rejection" [American Journal of Transplantation Volume 26, Issue 5, May 2026, Pages 962-979].

Lu H, Jiang J, Huang X, Peng T, Haig A, Jevnikar AM, Gunaratnam L, Zhang ZX

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026Senior author

DOI: 10.1016/j.ajt.2026.05.2297 PMID: 42297644

Nicotinamide mononucleotide protects septic hearts in mice via preventing cyclophilin F modification and lysosomal dysfunction.

Ni R, Ji XY, Cao T, Liu XW, Wang C, Lu C, Peng A, Zhang ZX, Fan GC, Zhang J, Su ZL, Peng TQ

Acta pharmacologica Sinica2025

DOI: 10.1038/s41401-024-01424-3 PMID: 39623043

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

Khajehzadehshoushtar S, Delfinis LJ, Rahman FA, Garibotti MC, Gandhi S, Brahmbhatt AN, Morris BA, Garlisi B, Lauks S, Aitken C

Journal of Physiology20254 citations

DOI: 10.1113/jp287912

An acidic pH environment converts necroptosis to apoptosis.

Lu H, Xu L, Steriopoulos J, McLeod P, Huang X, Min J, Peng T, Jevnikar AM, Zhang ZX

Biochemical and biophysical research communications2024Senior author

DOI: 10.1016/j.bbrc.2024.150215 PMID: 38870845

Inhibition of NK cell cytotoxicity by tubular epithelial cell expression of Clr-b and Clr-f.

Fuhrmann B, Jiang J, Mcleod P, Huang X, Balaji S, Arp J, Diao H, Ma S, Peng T, Haig A, Gunaratnam L, Zhang ZX, Jevnikar AM

Current research in immunology2024

DOI: 10.1016/j.crimmu.2024.100081 PMID: 39113760

The CaMK Family Differentially Promotes Necroptosis and Mouse Cardiac Graft Injury and Rejection.

Lu H, Jiang J, Min J, Huang X, McLeod P, Liu W, Haig A, Gunaratnam L, Jevnikar AM, Zhang ZX

International journal of molecular sciences2024Senior author

DOI: 10.3390/ijms25084428 PMID: 38674016

Cyclophilin D Regulates the Nuclear Translocation of AIF, Cardiac Endothelial Cell Necroptosis and Murine Cardiac Transplant Injury.

Qamar A, Zhao J, Xu L, McLeod P, Huang X, Jiang J, Liu W, Haig A, Zhang ZX

International journal of molecular sciences2021Senior author

DOI: 10.3390/ijms222011038 PMID: 34681708

Toll-like receptor 3 is an endogenous sensor of cell death and a potential target for induction of long-term cardiac transplant survival.

Zhao J, Huang X, Mcleod P, Jiang J, Liu W, Haig A, Jevnikar AM, Jiang Z, Zhang ZX

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021Senior author

DOI: 10.1111/ajt.16584 PMID: 33784431

miR-149-3p reverses CD8+ T-cell exhaustion by reducing inhibitory receptors and promoting cytokine secretion in breast cancer cells.

Zhang M, Gao D, Shi Y, Wang Y, Joshi R, Yu Q, Liu D, Alotaibi F, Zhang Y, Wang H, Li Q, Zhang ZX, Koropatnick J, Min W

Open biology2019

DOI: 10.1098/rsob.190061 PMID: 31594465

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2019

Subject: Prospective PhD student: Apoptosis Dear Professor Zhang, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Adenosine deaminase acting on RNA 1 and receptor-interacting serine/threonine-protein kinase-1 orchestrate the Z-DNA-binding protein 1-mediated PANoptosis and mouse heart transplant rejection." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "TLR3 is an endogenous sensor of cell death and a potential target for induction of long-term heart transplant survival" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Zhu-Xu Zhang

Research

Latest papers

Latest funding

Adenosine deaminase acting on RNA 1 and receptor-interacting serine/threonine-protein kinase-1 orchestrate the Z-DNA-binding protein 1-mediated PANoptosis and mouse heart transplant rejection.

Corrigendum to "Adenosine deaminase acting on RNA 1 and receptor-interacting serine/threonine-protein kinase-1 orchestrate the Z-DNA-binding protein 1-mediated PANoptosis and mouse heart transplant rejection" [American Journal of Transplantation Volume 26, Issue 5, May 2026, Pages 962-979].

Nicotinamide mononucleotide protects septic hearts in mice via preventing cyclophilin F modification and lysosomal dysfunction.

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

An acidic pH environment converts necroptosis to apoptosis.

Inhibition of NK cell cytotoxicity by tubular epithelial cell expression of Clr-b and Clr-f.

The CaMK Family Differentially Promotes Necroptosis and Mouse Cardiac Graft Injury and Rejection.

Cyclophilin D Regulates the Nuclear Translocation of AIF, Cardiac Endothelial Cell Necroptosis and Murine Cardiac Transplant Injury.

Toll-like receptor 3 is an endogenous sensor of cell death and a potential target for induction of long-term cardiac transplant survival.

miR-149-3p reverses CD8+ T-cell exhaustion by reducing inhibitory receptors and promoting cytokine secretion in breast cancer cells.

TLR3 is an endogenous sensor of cell death and a potential target for induction of long-term heart transplant survival

Characterization of endothelial cell death biomarkers for better prediction and prevention of renal fibrosis triggered by acute kidney injury

Regulation of pretransplant ischemic injury and cardiac allograft vasculopathy

The Canadian National Transplant Research Program: Increasing Donation and Improving Transplantation Outcomes

Regulation of pretransplant ischemic injury and cardiac allograft vasculopathy

Regulation of renal tubular epithelial cell injury to promote kidney allograft survival

Frequent collaborators

Aaron Haig

Bertha Garcia

Xiufen Zheng

Lakshman Gunaratnam

Weiping Min

Tianqing Peng

Anthony Jevnikar

Douglas Quan

Patrick Luke

Terry Zwiep

James Koropatnick

Jim Petrik

James Petrik