Xiufen Zheng, Western University

Research

Read how they describe their research on their Western University profile.

Heart Transplantation Immune Rejection (R)Ip Circular Rna Dendritic Cells Heart Failure Immune Suppression Immune Tolerance

Latest papers

RNA on Display: Cell Surface RNA as a Novel Layer of Cellular Regulation.
Research (Washington, D.C.) · 2026 · senior author
Targeting mitochondrial quality control for myocardial ischemia-reperfusion injury.
Mitochondrion · 2025
Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression.
Frontiers in cell and developmental biology · 2025 · senior author

All 66 publications

Latest funding

The role of circular RNA AEBP2 in dendritic cells
NSERC · 2019 · Principal investigator
$192,000
The role of circular RNA in heart transplantation
CIHR · 2018 · Nominated PI
$849,150
Inducing Mismatch Repair Deficiency in Cancer Cells for Therapeutic Benefit
CIHR · 2017 · Co-investigator
$983,025

All 7 grants and awards

66 publications.

01

RNA on Display: Cell Surface RNA as a Novel Layer of Cellular Regulation.

Chahal S, Jose P, Greasley A, Vytlingam K, Thapa RK, Pyne H, Omar AA, Zheng X

Research (Washington, D.C.)2026Senior author

DOI: 10.34133/research.1147 PMID: 41767597

02

Targeting mitochondrial quality control for myocardial ischemia-reperfusion injury.

He Y, Ren S, Liu C, Zheng X, Zhu C

Mitochondrion2025

DOI: 10.1016/j.mito.2025.102046 PMID: 40419068

03

Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression.

Zhu C, Liu Q, Su Y, Zhang Y, Patel A, Greasley A, Jiang J, Quan D, Min W, Liu K, Zheng X

Frontiers in cell and developmental biology2025Senior author

DOI: 10.3389/fcell.2025.1577625 PMID: 40673270

04

Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target.

Wang TZ, Thapa RK, Yu F, Warsi A, Rong K, Jose P, Kashkoulinejad-Kouhi T, Win PW, Castellani CA, Mele T, Zheng X

Scientific reports2025Senior author

DOI: 10.1038/s41598-025-05652-3 PMID: 40594478

05

CircRNA Synthesis and Applications.

Greasley A, Li S, Liu K, Zheng X

Advances in experimental medicine and biology2025Senior author

DOI: 10.1007/978-981-96-9428-0_16 PMID: 40886281

06

circITGa9: A Novel Therapeutic Target for Cardiac Diseases.

Zheng X

Research (Washington, D.C.)2024First author

DOI: 10.34133/research.0312 PMID: 38371272

07

Circular RNA MAP2K2-modified immunosuppressive dendritic cells for preventing alloimmune rejection in organ transplantation.

Li S, Abu Omar A, Greasley A, Wang B, Wang TZ, Chahal S, Thapa RK, Quan D, Skaro A, Liu K, Zheng X

Bioengineering & translational medicine2024Senior author

DOI: 10.1002/btm2.10615 PMID: 38193111

08

PD-1 and PD-L1 inhibitors in cold colorectal cancer: challenges and strategies.

Lin KX, Istl AC, Quan D, Skaro A, Tang E, Zheng X

Cancer immunology, immunotherapy : CII2023Senior author

DOI: 10.1007/s00262-023-03520-5 PMID: 37831146

09

Inducing mismatch repair deficiency sensitizes immune-cold neuroblastoma to anti-CTLA4 and generates broad anti-tumor immune memory.

El-Hajjar M, Gerhardt L, Hong MMY, Krishnamoorthy M, Figueredo R, Zheng X, Koropatnick J, Maleki Vareki S

Molecular therapy : the journal of the American Society of Gene Therapy2023

DOI: 10.1016/j.ymthe.2022.08.025 PMID: 36068918

10

Hydrogen sulfide: A new therapeutic target in vascular diseases.

Zhu C, Liu Q, Li X, Wei R, Ge T, Zheng X, Li B, Liu K, Cui R

Frontiers in endocrinology2022

DOI: 10.3389/fendo.2022.934231 PMID: 36034427

The role of circular RNA AEBP2 in dendritic cells

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Zheng, Xiufen

$192,000

The role of circular RNA in heart transplantation

Nominated PICIHR2018Project Grant

Principal investigators: Zheng, Xiufen

Keywords: (R)Ip; Circular Rna; Dendritic Cells; Heart Failure; Heart Transplantation; Immune Rejection; Immune Suppression; Immune Tolerance; Microrna; T Cells

$849,150

Inducing Mismatch Repair Deficiency in Cancer Cells for Therapeutic Benefit

Co-investigatorCIHR2017Project Grant

Principal investigators: Koropatnick, James

Keywords: Crispr/Cas9 Technology; Dna Mismatch Repair; Immune Checkpoint Inhibitors; Immunotherapy; New Cancer Therapies; Sirna And Shrna

$983,025

The role of growth differentiation factor (GDF)15 in heart transplantation

Nominated PICIHR2015Operating Grant

Principal investigators: Zheng, Xiufen

Keywords: Adaptive Immunity; Cardiomyocyte; Dendritic Cell; Growth Differentiation Factor (Gdf)15; Heart Transplantation; Immune Rejection; Inflammation; Innate Immunity; Treg

$480,865

Methylation and HIF1 as regulators of miR-711 and its impact on stress-induced cell death

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Zheng, Xiufen

$175,000

The role of IDO1 vs IDO2 on tumour immune evasion and immune therapy

Co-investigatorCIHR2012Operating Grant

Principal investigators: Min, Wei-Ping

Keywords: 3 Deoxygenase (Ido); Cancer Immunology; Dendritic Cells; Gene Silencing; Immune Therapy; Indoleamine 2; Melanoma; Sirna

$313,349

Concurrent gene silencing of multiple TLR signaling patheays using targeted nanoparticles for DC-mediated immune tolerance in heart transplantation

Co-investigatorCIHR2012Operating Grant

Principal investigators: Min, Wei-Ping

Keywords: Dendritic Cells; Graft Rejection; Heart Transplantaion; Immune Tolerance; Rnai/Sirna; Tlr

$305,873

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Department of Surgery
PATHOLOGY & LABORATORY MEDICINE, Western University
Medicine
Surgery
Biochemistry
Physiology and Pharmacology
Other

Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Bertha Garcia

PATHOLOGY & LABORATORY MEDICINE, Western University

15 shared papers, latest 2010

Weiping Min

Department of Surgery

15 shared papers, latest 2025

Douglas Quan

Department of Surgery

11 shared papers, latest 2025

Tina Mele

Department of Surgery

6 shared papers, latest 2025

Anton Skaro

Department of Surgery

3 shared papers, latest 2024

Patrick Luke

Department of Surgery

3 shared papers, latest 2016

Hong Ling

Biochemistry

3 shared papers, latest 2016

Terry Zwiep

Department of Surgery

2 shared papers, latest 2017

Aaron Haig

PATHOLOGY & LABORATORY MEDICINE, Western University

2 shared papers, latest 2016

William Wall

Department of Surgery

1 shared papers, latest 2012

Dave Nagpal

Department of Surgery

1 shared papers, latest 2019

Jeremy Parfitt

PATHOLOGY & LABORATORY MEDICINE, Western University

1 shared papers, latest 2012

Ephraim Tang

Department of Surgery

1 shared papers, latest 2023

Bradley Urquhart

Physiology and Pharmacology

1 shared papers, latest 2013

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2019

Subject: Prospective PhD student: Heart Transplantation Dear Professor Zheng, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "RNA on Display: Cell Surface RNA as a Novel Layer of Cellular Regulation." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "The role of circular RNA AEBP2 in dendritic cells" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Xiufen Zheng

Research

Latest papers

Latest funding

RNA on Display: Cell Surface RNA as a Novel Layer of Cellular Regulation.

Targeting mitochondrial quality control for myocardial ischemia-reperfusion injury.

Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression.

Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target.

CircRNA Synthesis and Applications.

circITGa9: A Novel Therapeutic Target for Cardiac Diseases.

Circular RNA MAP2K2-modified immunosuppressive dendritic cells for preventing alloimmune rejection in organ transplantation.

PD-1 and PD-L1 inhibitors in cold colorectal cancer: challenges and strategies.

Inducing mismatch repair deficiency sensitizes immune-cold neuroblastoma to anti-CTLA4 and generates broad anti-tumor immune memory.

Hydrogen sulfide: A new therapeutic target in vascular diseases.

The role of circular RNA AEBP2 in dendritic cells

The role of circular RNA in heart transplantation

Inducing Mismatch Repair Deficiency in Cancer Cells for Therapeutic Benefit

The role of growth differentiation factor (GDF)15 in heart transplantation

Methylation and HIF1 as regulators of miR-711 and its impact on stress-induced cell death

The role of IDO1 vs IDO2 on tumour immune evasion and immune therapy

Concurrent gene silencing of multiple TLR signaling patheays using targeted nanoparticles for DC-mediated immune tolerance in heart transplantation

Frequent collaborators

Bertha Garcia

Weiping Min

James Koropatnick

Douglas Quan

Zhu-Xu Zhang

Tina Mele

Anthony Jevnikar

Anton Skaro

Patrick Luke

Hong Ling

Terry Zwiep

Aaron Haig

William Wall

Dave Nagpal

Alp Sener

Jeremy Parfitt

Ephraim Tang

Bradley Urquhart